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What Are the Latest Research Finding About Stem Cell Therapy Benefits For Knee Arthritis?



Stem cell therapy has emerged as the most promising treatment to stop and reverse the effects of degenerative disorders, such as knee arthritis. Research publications worldwide attest its effectiveness in fast becoming a non-invasive substitute to surgical method and an alternative source of knee cartilage cell regeneration.

Scientific studies show that stem cell therapy has higher success rate in improving pain and disability associated with knee arthritis compared to any other treatment. The bio-restorative procedure with its unique natural healing ability also stimulates the regeneration of the damaged knee cartilage reversing the effects of arthritis.

How does stem cell therapy treat knee arthritis?

Knee arthritis causes permanent damage to the articular cartilage. As a result, bones in the knee joint rub with each other as we walk or bend the knee. This leads to pain and disability.

Stem cells have the unique ability to self-renew themselves and replicate other cells. When these cells are harvested and injected into the knee affected by arthritis, it triggers redevelopment of the damaged cartilage. Stem cells increase in numbers by self-renewing and differentiating themselves into cartilage cells. These new cells gradually replace the damaged and dead cells and heal the injury. This allows redevelopment of the cartilage and reversal of the damage caused by knee arthritis.

Is stem cell therapy for knee arthritis an alternative to surgery?

Stem cell therapy is fast emerging an alternative to surgical treatment of knee arthritis. Non-invasive, it assures better and permanent healing, pain management, greater freedom from disability, and faster recovery. The procedure completely reverses the damage to the cartilage by helping it to regenerate and thus heals the degeneration associated with knee arthritis.

As stem cells are harvested from the body of the patient, these do not pose any risk of rejection. Once the healing is complete, you regain knee strength equal to the pre-arthritis level and lead a pain-free life for a significantly longer period. The degree and duration of relief is far superior to the outcome of any other treatment or pain management method.

What Does The Latest Research Show?

The latest research on stem cell therapy highlights its wider application to treat and reverse the damage caused by degenerative disorders. According to research findings published in the Expert Opinion in Biological Therapies, stem cells are able to renew the damaged knee cartilage and undo the effects of arthritis. In a wider study reported in the Clinical Journal of Sports Medicine, researchers discovered that almost a third of patients studied had their cartilage degradation completely reversed within 12 months of having the procedure.

The results of a pilot study published in 2013 termed stem cell therapy a breakthrough treatment for patients suffering from knee arthritis. It provides significant improvement relieving pain and disability without any hospitalization or invasive surgery. The Stem Cells journal claims accelerated healing and recovery from knee arthritis is possible when a patient is treated with stem cell therapy.

The outcome of an 18-patient study published in the Stem Cells Translational Medicine journal that asserts that “a single injection of stem cells reduces pain and inflammation” and “improves mobility.” All were French and German patients aged 50 to 75 and had debilitating arthritis symptoms in their knees, such as severe inflammation, considerable pain, and crippling disability, for more than 12 months. Divided in to three groups – low-dose, medium-dose, and high-dose stem – each had a single injection of stem cells. A review after six months revealed that all patients had improvements as far as the severity of pain, functional disability, and mobility are concerned. Researchers observed “statistically significant” recovery even in the group with the lowest dose.

An analysis of current research on pharmacologic and regenerative therapies for osteoarthritis published in the Bone Research journal (Mar, 2016) acknowledges stem cell procedure as a “long-term solution to repair and regenerate cartilage, alleviate symptoms and finally delay progression of osteoarthritis.”

Meanwhile scientists at the Whitaker Biomedical Engineering Institute in Johns Hopkins have successfully generated precursor cartilage cells from stem cells. Sponsored by the Arthritis Foundation, the project showcases the promise of creating new bone or cartilage that could replace or repair the damage to the knee caused by osteoarthritis.

Encouraged by the “bio-restorative” qualities of stem cell therapy, the Rush University Medical Center ran the first ever nationwide clinical study of Cartistem – a first of its kind cartilage regeneration stem cell drug – between 2013 and 2015. Injected in to the knee area, it is touted to repair knee cartilage damaged by osteoarthritis. The trial that ended in May 2015 was promising and a detailed outcome report is expected next year.

Researchers at the St. Louis-based Washington University School of Medicine have also developed a new stem cell technique that can resurface an arthritic knee joint. As reported in the Proceedings of the National Academy of Sciences journal, stem cells are programmed to develop a new cartilage that has anti-inflammatory molecules, which prevents reoccurrence of arthritis.

Mesoblast, a leader in stem cell medicines, made a presentation at 2016 Amsterdam World Congress of the Osteoarthritis Research Society International about its MPC-75-IA drug made to turn around effects of knee arthritis. The manufacturer claimed that a single shot of its product, an intra-articular stem cell injection, was capable of significantly improving “pain, disability, cartilage thickness, and joint structure within 24 months.”

R3 Stem Cell offers stem cell therapy for knee arthritis at clinics nationwide. Treatment is offered with amniotic stem cell therapy for knees, bone marrow and adipose derived stem cells. Call (844) GET-STEM today!


Yves-Marie Persa, Lars Rackwitzc, Rosanna Ferreiraa, et al. Adipose Mesenchymal Stromal Cell-Based Therapy for Severe Osteoarthritis of the Knee: A Phase I Dose-Escalation Trial. STEM CELLS Translational Medicine; May 23, 2016, sctm.2015-0245

Wei Zhang, Hongwei Ouyang, Crispin R Dass. Current research on pharmacologic and regenerative therapies for osteoarthritis. Bone Research 4, Article number: 15040; 01 March 2016

Franklin Moutosa, Katherine Glass, Sarah Compton. Anatomically shaped tissue-engineered cartilage with tunable and inducible anticytokine delivery for biological joint resurfacing. Proceedings of the National Academy of Sciences; August 2, 2016; vol. 113 no. 31

PRP Therapy for Bones and Joints


Platelet-rich therapy (PRP) is being used in surgeries to promote cell regeneration since 1987. The procedure involves taking the patient’s own blood, processing it in the laboratory to concentrate the platelets, and injecting the platelets into the body.



What are platelets?



Platelets are fragments of the megakaryocyte, which is a large cell in the bone marrow. Megakaryocytes differentiate and mature from stem cells, which retain the ability to renew themselves and turn into other specialized cells. In addition, platelets leave the bone marrow to circulate in the bloodstream. Platelets bring white blood cells to an injured area, facilitate blood clotting, release growth factors, and facilitate tissue regeneration.


Is PRP therapy proven to be effective?


There is much research to support that PRP therapy is effective for treating bone and joint conditions. Researchers studied 78 patients with knee osteoarthritis who received PRP injections. Compared to placebo saline injections, the study found that knees treated with PRP injections saw a reduction in stiffness and pain, and also, improved in function at the 3-month follow-up.


In a small study of patients with arthritic knees, MRI tests were used to evaluate joint damage following PRP injections. Patients receiving PRP injections had less pain after 12 months of therapy. In addition, MRIs showed that the degenerative process had not progressed in most patients who receive these treatments. The evidence also found that arthritis did not worsen, and patients had less pain than they did the previous year.


Am I a candidate for PRP therapy?


PRP does not help all patients with chronic pain, but it does work in certain situations. PRP appears to fail to treat symptoms in some people because of differences in PRP formulation and changes in certain variables, such as frequency of injections and the amount of PRP injected. PRP also does not appear to work for people with severe joint arthritis and degeneration.


How does PRP work?


When the concentrated platelet solution is injected into a damaged area, it stimulates the joint or bone causing mild PRP-2inflammation that triggers healing. As a result, new collagen forms, and as this collagen matures, it shrinks, tightens, and strengthens the body structures in the damaged area. The concentrated platelets also contain growth factors and bioactive proteins that initiate and accelerate tissue repair. These substances increase production of stem cells to stimulate connective tissue healing, bone repair and regeneration, and wound healing.


How does PRP compare to cortisone shots?


Cortisone shots offer only temporary pain relief by stopping inflammation. However, corticosteroids to not offer long-term healing like PRP. Studies show that PRP offers better tissue regeneration along with anti-inflammatory properties.


What body regions can be treated with platelet-rich platelet therapy?


PRP injections help regenerate many body areas, including the cervical (neck), thoracic (mid-back), and lumbar (low back) spine, elbows, shoulders, wrists, knees, hips, and ankles. Many orthopedic specialists use PRP therapy for sports injuries, degenerative joints, degenerative disc disease, and scoliosis.


How is platelet-rich plasma obtained?


Before a platelet-rich plasma procedure, the patient meets with the doctor for a consultation. After the decision to have PRP therapy is made, the blood is taken from the patient and placed in a special centrifuge. This device spins the blood to separate the platelets from the blood. After concentrating the platelets, the solution is injected into the damaged, injured, or degenerative body region.

Stem Cell Therapy is the Future of Orthopedic Medicine


Regenerative therapies for the musculoskeletal system are the future of orthopedic medicine. Stem cell therapy is an innovative treatment that heals musculoskeletal problems without the need for surgery. In the United States alone, there are more than 500,000 spinal fusions and 400,000 lumbar discectomies performed each year. To avoid surgery, many people are choosing alternate forms of treatment.


What are stem cells?


Stem cells are undifferentiated cells in the body that can become many specialized types of cells. Adult stem cells are different from embryonic stem cells in that they are derived from adults, usually the patient’s own body. Stem cells used to treat musculoskeletal problems are called mesenchymal stem cells (MSCs), which turn into cartilage cells and bone cells.


How does stem cell therapy work?


The stem cells are obtained from the patient by aspirating tissue from fat (adipose) or taking bone marrow solution bone-marrow-aspiration2from the hip bone (iliac crest). The cells are spun in a centrifuge machine to identify and separate the stem cells that help heal tissues. Stem cells are injected into the damaged or injured body structure, such as a tendon, ligament, or spinal disc.

The additional method of obtaining stem cells includes amniotic fluid. This is obtained from consenting mothers of those scheduled for a c-section. The fluid is processed at an FDA regulated lab and prepared for use.



How are the stem cells obtained?


The human body has many stem cell storage sites. The easiest method for obtaining stem cells is to remove them from the hip bone (iliac crest). The procedure is done at the physician’s office, and it begins with the patient lying face down on the exam table. The skin over the bone is cleaned with an antiseptic, then numbed using a lidocaine solution. Under x-ray guidance, a procedure needle is inserted into the bone’s cortex. The liquid marrow is then withdrawn into a syringe. After the needle is removed, a bandage is applied. After the procedure, the stem cells are processed in the laboratory to concentrate them.


What conditions are treated with stem cell injections?


Stem cell injections are often used for the treatment of:


  • Muscular tears
  • Chronic partial rotator cuff tears
  • Osteoarthritis of the shoulder, hip, knee, and ankle joints
  • Discogenic back pain
  • Meniscal and cartilage tears in the knee
  • Spinal facet pain
  • Chronic radiculopathy
  • Sacroiliac joint pain



What risks are associated with stem cell treatments?


The risks associated with stem cell injections include infection, nerve damage, and bleeding. However, these incidents rarely occur. There is no risk for allergic reaction since your own stem cells are used during the procedure. We recommend only effective, safe procedures for our patients.


When will I notice benefit from the injections?


The benefit occurs 2-3 months following the whole therapy protocol. For most patients, 3-4 injections are necessary, and we usually will only perform 3 injections within a 12-month time span.


Do stem cell injections work?


In a very recent study, researchers followed 18 patients who suffered from osteoarthritis of the knee, ankle, and/or hip. Each of these patients received one stem cell injection and were followed by laboratory and MRI tests for several months. All 18 patients showed therapeutic benefits, such as decreased pain, increased walking distance, and improved function scores. In addition, MRI results improved. In 2011, a study involving 339 patients with knee osteoarthritis found that 60% of patients had pain relief after the stem cell therapy. In addition, only 6% still required a total knee replacement.



Centeno C, Schultz J, Cheever M. Safety and complications reporting on the re-implantation of culture-expanded mesenchymal stem cells using autologous platelet lysate technique. Curr Stem Cell. 2011;5(1):81–93. doi: 10.2174/157488810790442796.

Emadedin M, Ghorbani-Liastani M, Fazeli R, et al. (2015). Long-Term Follow-up of Intra-articular Injection of Autologous Mesenchymal Stem Cells in Patients with Knee, Ankle, or Hip Osteoarthritis. Arch Iran Med, 18(6), 336-344.

Pak J. Regeneration of human bones in hip osteonecrosis and human cartilage in knee osteoarthritis with autologous adipose derived stem cells: a case series. J Med Case Rep. 2001;5:296. doi: 10.1186/1752-1947-5-296.

With Knee Injuries Stem Cell Therapy May be used with Other Procedures


Stem cell therapy is often acknowledged as a treatment to be used in lieu of other types of procedures, such as surgery. However, it’s been noted that at times it may not be a situation that calls for an either/or choice. There are various types of surgeries that can benefit from the added utilization of stem cells. This includes surgical procedures use to repair a torn meniscus.

The Meniscus

The meniscus, which is located in the knee region, is a half-moon shaped piece of cartilage. It sits between the weight bearing joint surfaces of the femur and the tibia. In essence, it’s a padded shock absorber that allows us to walk, run, jump, and move our legs without feeling any pain in that joint. In a normally functioning knee, there are two healthy menisci. One, which is the lateral meniscus, is located on the outside region, while t the medial meniscus is on the inside area.

When your meniscus is torn this triangular, cross section of cartilage, which is attached to the lining of the knee joint along its periphery, becomes ineffective as bone starts to hit bone. This can cause a great deal of pain, making movement difficult if not impossible.

Meniscus Repair

It’s been found that stem cells can benefit a patient who has had their torn meniscus repaired. The use of mesenchymal stem cells has been shown to help in the healing process associated with meniscus surgery. This is important due to the fact that the surgery alone has for years resulted in a failure rate of 20% to 24%.

Arthroscopy procedures are used to fix what is a common injury. The surgery is used to either repair the cartilage or in the partial excision of meniscal tears. There are over one million such procedures performed in the U.S. every year.

There are also recent studies showing stem cells for meniscal repair without surgery. Bone marrow stem cell therapy and amniotic stem cell therapy are being used to help with knee pain associated with meniscal tears anf often help facilitate repair.

What Stem Cells Can Do

When used in situations involving the meniscus the injection of mesenchymal stem cells helps to promote tissue growth and reduce inflammation. According to an article in the Journal of Bone and Joint Surgery, patients who have been observed in controlled studies have enjoyed overall improvement in the condition of their knee joint.

During a controlled study of sixty patients between the ages of sixteen and sixty who underwent a partial meniscectomy, the patients were divided into three groups. One group received an injection of 50 million human mesenchymal stem cells, another received an injection of 150 million stem cells, and the third, which was the control group, received no injection. Improvement was noted in those receiving the injections.

Mesenchymal stem cells are powerful agents due to the fact that they are multi-potent stromal cells of mesodermal origin. That means that they are connective tissue cells that can differentiate into a range of cell types. These types include articular cartilage and meniscal tissue. They act as anti-inflammatories and they do not appear to create adverse immune results.

Considering Options

Overall, surgery for a torn meniscus is fairly noninvasive. However, patients may first want to try injection therapy using mesenchymal stem cells. If the results prove to be disappointing, then an arthroscopic procedure supplemented by the injection of mesenchymal stem cells may offer the patient a positive result, allowing them to enjoy full physical activity again.


Top 5 Benefits of Amniotic Stem Cell Therapy

Amniotic stem cell material is harvested from the amniotic sac after a scheduled C-Section. The baby is fine and no embryonic stem cells are involved. In addition, the woman is consented and compensated. While some people may have ethical issues with embryonic stem cell therapy, most everyone agrees that the use of amniotic stem cell therapy raises no ethical or moral questions.

The amniotic fluid is processed at an FDA regulated lab according to Current Good Tissue Practice Standards. It is then cryogenically frozen until ready for use.

Here are the Top 5 Benefits of Amniotic Stem Cell Treatment:

  1. Repairs and Regenerates Tissue

Stem cell treatment takes advantage of the body’s ability to repair itself. With amniotic stem cell therapy, the sports medicine physician injects stem cehome_service03lls from amniotic tissues into your body. These stem cells have anti-inflammatory properties, similar to cortisone and steroid shots. However, stem cell therapy goes far beyond the benefits of standard “injection therapy.”

While cortisone and other drugs only provide temporary pain relief, stem cells actually restore degenerated tissue while providing pain relief. The growth factors in amniotic stem cells may replace damaged cells in your body. Additionally, stem cell injections contain hyaluronic acid, which lubricates joints and tendons, easing the pain and helping restore mobility.

  1. Stem Cells and Growth Factors

Amniotic stem cells contain several beneficial materials including

  • Stem Cells and Stem Cell Activators.
  • Hyaluronic Acid – the “motor oil” of the joint. Cushions and protects.
  • Growth Factors – there are a significant amount present.
  • Cytokines – help with anti-inflammation and pain relief.
  • Anti-microbial agents – helps prevent infection.
  1. The Procedure is Safe

Yes. More than 100,000 injections have been performed without a single reported adverse side effect. Amniotic stem cell therapy is a preferred type of stem cell therapy because the cells come from an immune-privileged site, which means that patient-rejection is extremely rare. With amniotic stem cells, there is no threat of patient rejection.

The use of amniotic stem cells is well researched, safe, and effective. Amniotic stem cells have been used by ophthalmologists and plastic surgeons for about 20 years. All amniotic stem cell donors go through a rigorous screening process, as determined by the Food and Drug Administration (FDA) and American Association of Tissue Banks (AATB).

  1. NonSteroidalstem-cells2

Amniotic stem cells contain no steroids. Instead, the injections rely on naturally occurring anti-inflammatory agents, such as cytokines. One of the biggest concerns about steroid injections is the potential harm they may produce on the body’s joints or blood sugars. Thankfully, amniotic therapy has none of these issues.

  1. NO Need to Harvest

There are several current types of stem cell therapy available. Bone marrow and fat derived procedures involve harvesting from the patient him or herself, which adds an extra step and may be painful.

Amniotic therapy does not involve any harvest from the patient.

R3 Stem Cell works with Centers of Excellence nationwide offering regenerative medicine with amniotic stem cell therapy. Treatment is offered for many conditions, and treatment is often partially covered by insurance (the visits, imaging and labwork).

Visit for more information and call (844) GET-STEM to find out more and schedule today!

Amniotic Stem Cell Therapy for Diabetic and Peripheral Neuropathy

Amniotic Stem Cell Therapy for
Diabetic and Peripheral Neuropathy

By David Greene MD, MBA
Neuropathic Pain
Diabetic and Peripheral Neuropathy pain affect 6% of the population.
70% of diabetics suffer from neuropathy.
Pain is sharp, burning, lancinating, electric.
Not just pain, the decreased sensation affects walking ability.
Neuropathy Traditional 
Treatment Options
Opioids and NSAIDs
Oral and Topical
Questionable Benefit
Off label tricyclic antidepressants, anticonvulsants.
Neurontin, Lyrica
TENS unit
Only 30% achieve adequate relief with these methods.
Neuropathy Traditional 
Treatment Options
Spinal Cord Stimulator Implant
Revolutionary for relief and sensation return.
Over 80% pain relief.
85% improved sensation, 58% sensory deficits reversed completely.
Regenerative Medicine
The NEW paradigm, a nonoperative treatment that can actually repair damaged tissue. Provides pain relief and improved sensation.
Low risk, outpatient, effective – isn’t that what medicine has been looking for?
Consider this:
20 years ago plastic surgery was 90% operative. Now it’s 90% nonoperative!
Regenerative Options for
Diabetic and Peripheral Neuropathy
PRP Therapy
Blood draw, spun in centrifuge concentrates platelets/growth factors.
Bone Marrow
Adipose (fat)
The newest – Amniotic
Not really new
Used for decades
Amniotic Stem Cell Therapy
Remarkable addition to regenerative medicine.
Obtained from consenting donors after scheduled c-section.
FDA Regulated (CGTP)
AATB Certified
Cryogenically Frozen
No embryonic cells or fetal involvement
Amniotic Qualities
Immunologically Privileged
No Rejection Reaction
Growth Factors
Hyaluronic Acid
Stem Cells and Activators
Amniotic stays on dry ice or in cryogenic freezer until ready to use.
Thaw for 10 minutes.
Usually 1-2 cc’s per limb, ok to dilute 3:1 with sterile water/saline/lidocaine.
Procedure takes less than a half hour.
We know that mesenchymal stem cells in animals significantly reduce neuropathic pain.
A preliminary report on stem cell therapy for neuropathic pain in humans – J Pain Res 2014
10 pts, In this preliminary proof-of-concept study, the administration of a mixed population of adipose-derived cells, including MSCs, was shown to be able to attenuate orofacial neuropathic pain symptoms in a diverse range of patients considering variables of age and the established duration of the pain state.

Anti-Inflammatory Mesenchymal Stem Cells (MSC2) Attenuate Symptoms of Painful Diabetic Peripheral Neuropathy 2012 Stem Cells Transl Med.
Over 40% inflammatory and pain reduction in mice.
Related to their capacity to not only control pain as a symptom, but to modulate the neuroimmune component which plays a relevant role in neuropathic pain.

Risks have been absolutely minimal.
Have not seen rejection
NO steroid.
It’s antimicrobial so risk of infection has been minimal.
Currently amniotic stem cell therapy for neuropathy is an out of pocket expense.
Insurance will cover the visits, imaging, lab work but NOT the amniotic material.
New technology takes a while to capture reimbursement.
Bottom Line
Amniotic therapy works in preclinical studies and in early human pilot studies.
It is low risk, potential high benefit, and has live cells depending on processing.
No embryonic stem cells or fetal involvement!
Can help you and your loved ones avoid surgery and achieve relief and walk better.
R3 Stem Cell
R3 partners with top providers nationwide to offer regenerative treatments for all types of musculoskeletal conditions – knee, hip, shoulder, ankle, elbow, wrist, etc.
This includes back and neck conditions as well as neuropathy.
Visit us at and call us to find a treatment center at (844) GET-STEM.

What are the Benefits of Stem Cell Therapy?

A small number of stem cells taken from the body can grow in the laboratory setting to create millions of new stem cells. Known as regenerative medicine, stem cell-based therapies hold the promise of replacing and repairing damaged and disease body structures.

What ethical issues are associated with adult stem cell therapy?

Adult stem cells do not come from embryos. They cannot develop into a new human being. Rather, these cells reside in the fat and bone marrow in large quantities.stem-cells2

How do I know if stem cell therapy is right for me?

Consult with your orthopedic specialist if you suffer from a degenerative disease, have an acute injury, or have chronic joint pain. Stem cells come from the patient’s own body, and these cells help heal and repair damaged tissues.

What are the side effects of stem cell therapy?

Stem cell therapy is a safe procedure. After you undergo a medical evaluation, the specialist will determine if you are a candidate for this particular therapy. Some patients experience soreness and pain right after the procedure. However, because autologous (from the patient) fat and blood are used, there is no chance for allergic reaction.

What are the benefits of stem cell therapy?

Repair, healing, and regeneration of damaged or injured tissue are the main benefits of stem cell therapy. Stem cells can regenerate tissues that are injured, such as ligaments, menisci, and the rotator cuffs. In addition, tissues that are chronically damaged can be repaired from diseases such as osteoarthritis, tennis elbow, and bursitis. Stem cell therapy is a procedure offered in the office setting using local anesthesia, which eliminates the risks associated with general anesthesia.

How do stem cells from fat differ from those derived from bone marrow?

Adipose (fat) stem cells and stem cells from bone marrow both are adult mesenchymal stem cells. Adipose stem cells are collected bone marrow aspiration2form a mini-liposuction procedure, whereas bone marrow stem cells are aspirated from the hip bone. While adipose stem cells have regenerative properties to make blood vessels (essential for nutrient and oxygen delivery to tissues), bone marrow stem cells have superior ability to differentiate into cartilage, ligaments, and bone.

How do I prepare for the stem cell therapy procedure?

To prepare the body to better receive the stem cells, we encourage patients to undergo a simple detox before the treatment. This involves stopping smoking, avoiding alcohol, and taking vitamins, which cleanses the system from toxins.

How is the stem cell injection done?

To assure correct placement, stem cell injections are done using fluoroscopy (x-ray guidance), which allows the doctor to visualize the site of injury and offer effective, accurate treatment. After cleansing the skin with an antiseptic solution, the needle is guided into the treatment region, and the stem cells are injected.

How soon can I go back to usual activities after stem cell injection?home_service01

The procedure is done outpatient, so you are allowed to leave the medical facility that day. Patients are typically sore during the first couple of days following the injection, but they can return to work after 3-4 days. This depends, however, on the site of treatment and the type of physical activity required for the patient.

Are stem cell injections effective?

In recent research studies, intra-articular stem cell injections for arthritis have been investigated. Studies used both bone marrow-derived and adipose-derived stem cells. Researchers found that injection of stem cells allowed for improvement in pain scores, increased range of motion, and better outcome scores at 6-12 months post-procedure. In addition, researchers found that participants had increases in cartilage growth and thickness, which were evident on MRI.


Centeno CJ, Busse D, Kisiday J, Keohan C, Freeman M, Karli D. Increased knee cartilage volume in degenerative joint disease using percutaneously implanted, autologous mesenchymal stem cells. Pain Physician. 2008;11(3):343–353.

Davatchi F, Abdollahi BS, Mohyeddin M, Shahram F, Nikbin B. Mesenchymal stem cell therapy for knee osteoarthritis. Preliminary report of four patients. Int J Rheum Dis. 2011;14(2):211–215.

Emadedin M, Aghdami N, Taghiyar L, et al. Intra-articular injection of autologous mesenchymal stem cells in six patients with knee osteoarthritis. Arch Iran Med. 2012;15(7):422–428.

Orozco L, Munar A, Soler R, et al. Treatment of knee osteoarthritis with autologous mesenchymal stem cells: a pilot study. Transplantation. 2013;95(12):1535–1541.

Varma HS, Dadarya B, Vidyarthi A. The new avenues in the management of osteo-arthritis of knee – stem cells. J Indian Med Assoc. 2010;108(9):583–585.

FAQs on Amniotic Stem Cell Therapy

Amniotic fluid is highly concentrated in proteins, cytokines, stem cells, and other components that are useful for the boy. Clinical studies show that amniotic fluid and stem cells have many benefits.stem-cells2

What are amniotic stem cells?

Amniotic fluid is the fluid that surrounds the fetus during pregnancy. After delivery of the baby, the amniotic fluid is disguarded. Now, many consenting mothers are donating this fluid because of its regenerative stem cell properties. Amniotic stem cells are useful for reducing inflammation and scar tissue. These stem cells do not come from the embryo, but rather, they are in the fluid and the amniotic sac.

What are the benefits of amniotic stem cell therapy?

Amniotic stem cell therapy is an effective, safe treatment with absolutely no risk for rejection to the patient. The fluid contains many growth factors that stimulate new tissue growth, reduce inflammation, and activate stem cell properties. In addition, amniotic fluid contains hyaluronic acid, which serves as a joint lubricant and promotes growth of new cartilage.

Who is a candidate for amniotic stem cell therapy?

Amniotic stem cell therapy is ideal for patients who have:

  • Soft tissue or intra-articular injuries, including cartilage and meniscus
  • OsteoarthritisBackPain copy
  • Achilles tendon tears
  • Sacroiliac pain
  • Ligament or tendon tears
  • Epicondylitis
  • Rotator cuff injuries
  • Tennis elbow and golfer’s elbow
  • Joint pain
  • Low back pain
  • Neck pain

How is amniotic stem cell fluid obtained?

When the fetus is developing, the amniotic fluid contains a high concentration of stem cells. The fluid has more stem cells than bone marrow and adipose (fat) tissue. The fluid is obtained during a caesarian delivery, and the stem cells are harvested in a centrifuge process in the laboratory. After an activation solution is added, they are processed to produce the biological injectable fluid. This injection produces anti-inflammatory agents when placed into the injured or damaged body region.

Can amniotic stem cells help with back problems?

Currently, amniotic stem cell therapy is being used as a form of spinal fusion, where back surgery has failed to relieve pain or for people who are not candidates for spinal fusion surgery. These products surround the spinal cord to inhibit scar tissue formation. Favorable results show that these injections help with degenerative arthritic pain, where tissue is regenerated after 1-3 injections.

Are amniotic sR3 Horizontal smaller logotem cell injections safe?

Thousands of amniotic stem cell injections have been performed with no reported adverse side effects. Amniotic stem cell therapy is actually the preferred method because the cells are derived from an immune-privileged site. The use of these cells is well-researched, effective, and safe, approved by the Food and Drug Administration (FDA) and American Association of Tissue Banks (AATB).

Is amniotic stem cell therapy effective?

In a large study of patients with chronic discogenic back pain, researchers conducted a randomized controlled study. In the amniotic stem cell therapy group, patients showed much improvement of pain after treatment. All participants reported improvement after the 3rd and 6th months, and two-thirds continued to have improvement after one year. The amniotic fluid cell therapy group had a much more sustained effect compared to the long-acting steroid group in this study.


Bhattachary N (2012). Amniotic Fluid Cell Therapy to Relieve Disc-Related Low Back Pain and Its Efficacy Comparison with Long-Acting Steroid Injection. Human Fetal Tissue Transplantation, 251-264.

An Overview of PRP Therapy: How It Works and What It Does

Platelet rich plasma (PRP) therapy is being utilized increasingly to help enhance and encourage the healing process for those who have soft tissue and bone injuries. PRP has received increased attention from the media as it has been used to help high profile athletes who have suffered injuries mend more quickly and efficiently. It has been effective in reducing inflammation and in boosting cell proliferation, both of which are important aspects of the healing process.

Defining PRP

PRP is derived from one’s own body, coming directly from a person’s blood. It uses one kind of cell that is found in the blood, platelets. PRP is a substance that has a heavy concentration of these cells, which circulate within the blood and are an important factor in clotting. Plasma, which is also found in our blood and is aprp2
component in PRP, is involved in providing the body with key substances. Together platelets and liquid plasma, which combine to create PRP, are important in that they possess certain factors that help in the enlistment, multiplication, and specialization of cells, all of which are essential to the healing process.

PRP Therapy

PRP therapy begins with blood being drawn from the patient; it is then placed in a centrifuge where it is spun in order to separate the blood into its various components. The plasma, which is platelet rich, is collected and treated prior to being administered to the injured region.

When a patient undergoes PRP therapy they are given injections in the area of injury. When administering the treatment a healthcare professional will often utilize ultrasound guidance to ensure accuracy in treating the specific bone or soft tissue region, which may be a designated ligament or tendon.

After the patient receives the injection, there is a short period of time where they will avoid all exercise. After that, they begin an exercise program designed to physically rehabilitate the injured area.

Efficacy of PRP

There is evidence based on scientific studies focusing on animals in which therapy that uses PRP has been revealed to be effective in aiding the healing of bone and soft tissue. As an example, in calf muscle injuries in which the Achilles tendon has been damaged there has been evidence of increased numbers of cells and heightened PRP-2tendon strength. Also, increased muscle regeneration has been noted.

There have also been promising but limited studies involving humans. PRP therapy was revealed to be efficacious in a small study focusing on knee osteoarthritis. In this study PRP was shown to be more effective than hyaluronic acid treatment. In addition, there have also been positive results in treatment with PRP that focuses on rotator cuff tears and medial collateral ligament (MCL) knee injuries.

However, there is also a study published in the Journal of the American Medical Association that noted there was no advantage to utilizing PRP injections when compared to placebo injections of saline for the treatment of Achilles tendinosis. Still, despite the lack of of evidence as to the efficacy of PRP, it has started to take root as a treatment that can aid in the healing process due to the fact that it carries an extremely low-risk and the substance used is derived directly from the patient’s blood.

With promising results in animal models, there has been increased activity in using PRP for various conditions, including chronic and acute tendon issues and injuries to muscles and ligaments. Conditions that have responded especially well to PRP include those related to lateral epicondylitis (tennis elbow) and Achilles tendinosis, which affects the Achilles tendon.

As more studies are developed regarding the use of PRP and more evidence becomes available as to its effectiveness, it’s anticipated that the therapy will become more widespread. Also, studies will go a long way to helping to standardize treatment.

Cautions Regarding Treatment

Although PRP therapy involves minimal risk, there are certain cautions that should be taken when utilizing this type of approach. When undergoing treatment all anti-inflammatory medications should be stopped, as PRP is designed to aid in the reduction of inflammation and aid in healing. Also, athletes who will be involved in certain competitions need to be aware that PRP contains endogenous growth factors, which certain agencies, such as the World Anti-Doping Agency and the United States Anti-Doping Agency, forbid. This is due to the possibility that PRP might enhance one’s performance, although there is no evidence of such.

Considering PRP Therapy

There are some important points to remember concerning platelet rich plasma (PRP) therapy, including that this is a substance that is extracted from the injured party’s blood, and comprised of components in their blood, specifically platelets and plasma. PRP contains a high concentration of growth factors (at least 7) and of those factors involved in cellular signaling, both of which are considered to be important in aiding the healing process.

An increasing amount of human studies are attesting to the effectiveness of PRP therapy for soft tissue injury, arthritis, tendonitis, ligament tear healing and more. Call (844) GET-STEM to find a PRP therapy treatment center today!

FAQs on Amniotic Stem Cells for Diabetic Foot Ulcer Treatment

What is a Diabetic Foot Ulcer?

People who suffer from diabetes are at risk of developing ulcers on their feet. Diabetic foot ulcers affect up to 15 percent of diabetic patients, and over 80 percent of lower leg amputations are done in the treatment of this condition.

What causes a Diabetic Foot Ulcer?

Diabetic foot ulcer is a complication resulting from physiological changes due to the patient’s diabetes mellitus. Due to diabetic foot ulcerthe vascular pathologies and neuropathy that results from diabetes, wound healing is compromised.

  • Diabetes is thought to cause changes in the bony architecture of the foot, leading to predisposition to injury. The glycosylation from diabetes causes the ligaments to be stiffer, leading to loss of coordination and control of foot movements. The increased mechanical stresses on the foot from this condition can cause small, undetected wounds that can eventually lead to diabetic foot ulcer.
  • There are changes in the vasculature, including atherosclerosis (stiffening of the blood vessels), calcification of arteries, and thickening of capillary basement membranes. The compromised blood flow leads to poor healing of injuries, such as wounds and breaks in the skin. Rather than being replaced by normal tissue, tissue degeneration and ulceration occur.
  • Another complication of diabetes is peripheral neuropathy, leading to decreased sensation around the foot. Due to this loss of sensation, injuries to the foot are not noticed, often until too late.

What is the standard treatment for diabetic foot ulcers?

The treatment of diabetic foot ulcers is complicated and requires a multi-specialty team composed of orthopedic surgeons, internists, and rehabilitation specialists. The standard treatment of diabetic foot ulcer is the administration of antibiotics to prevent infection, debridement of damaged tissues, and proper wound dressing.

How are amniotic stem cells used in the treatment of diabetic foot ulcers?

Stem cell therapy for the treatment of diabetic foot ulcers is based on the goal of promoting better wound healing and cellular reconstruction with pluripotent cells. Among the many kinds of stem cells that are being explored for treatment are mesenchymal stem cells, which are derived from the amniotic membrane, as well as other tissue types, including bone marrow, umbilical cord blood, and fat tissue.

Mesenchymal stem cells are among the most commonly studied stem cells. They have been shown to differentiate into many different kinds of tissue. They are easy to collect and do not elicit a strong immune response. Studies have shown that the transplantation of mesenchymal stem cells has positive effects on diabetic foot ulcers, which include:

  • Cell proliferation
  • Collagen synthesis
  • Release of growth and healing factors[ File # csp9441400, License # 2035621 ] Licensed through in accordance with the End User License Agreement ( (c) Can Stock Photo Inc. / 72soul
    • Angiopoietin-1
    • EGF
    • KGF
    • TGF-beta1
    • VEGF
    • SDGF-1alpha
    • IGF-1
    • IL-8
    • PDGF
  • Growth of new blood vessels
  • Wound contraction

Amniotic stem cells have been used clinically for diabetic foot ulcers extensively over the past decade. Whereas traditional treatments work slowly for healing diabetic ulcers, the amniotic therapy often heals them much quicker.

With the amniotic fluid being so readily available and having no rejection, it’s a great option as there is often a problem using a diabetic individual’s own bone marrow adipose tissue for stem cell therapy. For that reason, the “ready to go” amniotic therapy is excellent!


Blumberg SN, Berger A, Hwang L, Pastar I, Warren SM, Chen W. The role of stem cells in the treatment of diabetic foot ulcers. Diabetes Res Clin Pract. 2012 Apr;96(1):1-9. doi: 10.1016/j.diabres.2011.10.032.

Futrega K, King M, Lott WB, Doran MR. Treating the whole not the hole: necessary coupling of technologies fordiabetic foot ulcer treatment. Trends Mol Med. 2014 Mar;20(3):137-42. doi: 10.1016/j.molmed.2013.12.004.

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