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A Non-Invasive Option for Chronic Kidney Disease
Disclaimer:
The information provided by R3 Stem Cell is for educational purposes and is not a substitute for professional medical advice, diagnosis, or treatment. Individual results may vary and are not guaranteed. The FDA considers stem cell therapy experimental at this point.
Any claims made on this website refer to procedures performed OUTSIDE of the USA. R3 Stem Cell has clinics in Mexico, Philippines, South Africa, Turkey, India, Pakistan.
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The number of individuals affected with chronic kidney disease (CKD) is rising worldwide, mainly due to a remarkable increase in atherosclerosis, type 2 diabetes and high blood pressure. An estimated 8–16% of the general population has CKD, and its prevalence increases with age to about 30% in people aged over 70 years.
The kidneys are critical for so many functions. They remove waste products and excess fluid from the body. They control the production of red blood cells and produce an active form of Vitamin D that promotes strong bones. They release hormones that regulate blood pressure, and remove a lot of drugs from the body.
All in all, healthy kidneys filter about 200 liters of blood per day.
Struggling with CKD? Let’s talk. Call (844) GET-STEM now.
High blood pressure and diabetes are the two most common causes of kidney failure. 13% of all US adults have CKD. There are various medications which may also lead to CKD, such as chronic use of NSAIDS, transplant medications, diuretics, and others.
There are five stages of kidney disease as follows:
Mild disease where the GFR is still over 90 ml/min.
Mild with GFR from 60-89.
Moderate with GFR 30-59.
Severe with GFR 15-29, anemia and high blood pressure.
GFR drops below 15, this is critical.
When symptoms do occur, they may consist of:
Itching
Muscle cramps
Feeling sick and throwing up
Not feeling hungry
Lethargic
Swelling in your hands and feet
Back pain
Urinating (peeing) more or less than normal
Trouble breathing
Trouble sleeping
Ready for a consultation? Connect with R3 Stem Cell at (844) GET-STEM.
There is no “cure” for chronic kidney disease, but patients can help themselves tremendously with lifestyle changes. These may include ceasing smoking, exercising, limiting alcohol intake, restricting salt intake and eating a healthy, balanced diet.
Medications are aimed at helping the conditions that cause CKD. This may include medications for high blood pressure, diabetes, high cholesterol, etc.
Interested in stem cell therapy for kidney failure? Call (844) GET-STEM.
Eventually, CKD patients end up with end stage disease. This is where the economic burden becomes evident. Dialysis is not only expensive, but it’s “annoying” as patients have to devote several days per week, hours at a time, to being hooked up to a machine. The average lifespan of a patient who begins dialysis ranges from five to ten years.
Undergoing a renal transplant is also expensive, with potential risks that may include rejection. Patients need to take immune suppression drugs for life, which opens the possibility to opportunistic infections. The average wait time for a transplant is 3.5 years, with 13 people dying daily in the USA waiting.
If a new technology such as mesenchymal stem cell and exosome therapy could either reverse CKD or slow the progression, it would and should become first line therapy.
Stem cells and exosomes act in the body through several mechanisms. They do NOT become part of a patient’s DNA, which means they do not engraft into the person’s existing cells.
They act through:
Angiogenesis
Provokes formation of new blood vessels.
Reduce inflammation
most chronic disease is associated with significant inflammation, and the regenerative biologics reduce it nicely.
Immune system modulation
the stem cells and exosomes modulate the immune system very differently than steroids. Instead of blanketly suppressing the immune system, the regenerative biologics tamp down the harmful processes while amping up the beneficial ones.
Cellular signaling
the biologics are able to perform “cell to cell” communication. This promotes recipient cells to proliferate their growth factor production, protein production and regenerate tissues that are damaged.
Prevent cell death
most cells have a timed death, where they are only allowed to live a certain length of time. This is called apoptosis. The regenerative biologics allow normally functioning cells to live longer, and spare them from the pre-programmed death.
Preventing scar tissue
CKD patients experience significant scarring of the kidney parenchyma. Once that scar tissue forms, it becomes nonfunctional. Stem Cells and exosomes are great at preventing scar tissue (anti-fibrosis).
It’s important to understand that while stem cells are incredible for improving kidney function, some patients are too far gone. For those whose kidneys have shrunk significantly and the eGFR is below 7, stem cell therapy is most likely not indicated.
However, we have seen plenty of patients do great even while receiving dialysis. Some patients who haven’t urinated in over a year are able to improve to the point of getting off dialysis and urinating just fine! It’s important to note that outcomes will vary and are not guaranteed.
Get informed about non-surgical kidney support. Call (844) GET-STEM.
Where do the stem cells and exosomes come from?
R3 Stem Cell’s regenerative biologics originate from umbilical cord tissue that has been donated after a scheduled c-section. No baby (or mother) is harmed during the c-section procedure. The umbilical cord tissue is normally discarded, but if the mother passes screening test then the umbilical cord is immediately sent to the lab.
The lab carefully processes the umbilical cord to generate large amounts of stem cells and exosomes that are of the highest quality possible. The lab team consists of multiple PhD’s working in ISO Certified, cGMP compliant clean rooms to ensure quality assurance that exceeds USA FDA standards. The proprietary production process combines the highest potency, safety and affordability for providers to confidently offer exosome procedures.
Millions of dollars have been invested into the pharmaceutical grade production of the biologics including first rate clean rooms, bioreactors, nano-particle tracking analyzers, cytometers, PCR, tangential flow machines and real time environmental monitoring. The quality assurance testing complies with screening and testing stan¬dards consistent with the American Association of Tissue Banks, cGMP standards, FDA regulations and the highest level of any regulatory agency globally.
Absolutely! There are too many studies to mention all of them in this guide, but we’ll touch on some compelling ones.
In 2017, a 62 year old Indonesian woman with chronic kidney disease on hemodialysis underwent umbilical cord mesenchymal stem cell therapy. Prior to treatment, her creatinine level was 11 mg/dl.
After treatment with approximately 180 million umbilical cord stem cells, her creatinine dropped to 9mg/dl within 3 weeks. After a few months, she received a second treatment which dropped her creatinine from 9 mg/dl to 2 mg/dl. She had started urinating on her own as well, which she wasn’t doing at all for the previous two years (1)!
In a 2016 clinical trial randomizing 40 CKD patients evenly between IV exosomes versus IV saline as a control, the participants were followed for a year (2). While the control group showed no improvements, the exosome group displayed:
eGFR increase from 31 ml/min average to 47 ml/min.
Creatinine reduced from 3.4 average to 2.2.
In a 2014 Chinese study evaluating 81 patients with renal failure secondary to lupus, the participants were treated with umbilical cord mesenchymal stem cells at 1 million/kg. Sixty one percent of the participants achieved remission for the year. GRF increased from an average of 59 to 70 ml/min. There were no adverse events, and patients routinely were able to taper both steroid and immunosuppressive drugs.
In a stem cell review for kidney disease published by USC, the authors noted an excellent reduction of BUN and improved glomerulosclerosis after MSC therapy in several studies (4). Their review showed no significant adverse events in any study.
R3’s experience with stem cell and exosome therapy for CKD has been similar to these results. In the vast majority of patients, improvements in eGFR, creatinine, BUN and quality of life are seen. Patients report increased energy, renewed vitality and are amazed that their labs actually improve while traditional treatments are failing.
References
Stem Cell Derived Exosomes
R3 Stem Cell’s Centers of Excellence globally include umbilical cord stem cell derived exosomes with umbilical cord stem cells to provide enhanced results. Exosomes are lipid bound vesicles (acellular) produced by cells which contain a plethora of growth factors, cytokines, mRNA and other proteins.
They are exceptionally helpful in cell to cell communication, and very effective for reducing inflammation when they become ingested by their recipient cell. They act as shuttles to send nucleic acids and proteins to other cells, in this way, allowing cell-to-cell communication and transporting molecules among both close and distant cells. In general, these released proteins are important regulators of intracellular information.
Exosomes could be the mediators of many stem cellassociated therapeutic activities. Considering they are 100 times smaller than stem cells, they do not have any issues passing through the lungs to reach the kidneys from the bloodstream.
Discuss Your Kidney Concerns
After a decade of performing over 23,000 stem cell procedures worldwide, R3 knows that the regenerative procedures are safe. The quality control employed during the stem cell production is second to none, and the side effects R3 sees are usually mild to moderate and temporary.
They may include itching, dizziness, lightheadedness, low grade fever, chills, headache, nausea. These are typically temporary. If a patient has an allergic reaction to the multivitamin or a preservative, all of R3’s Centers have the medications to resolve it quickly.
One of the questions we get asked a lot is, “Will the stem cells get rejected?” The answer is NO, as the stem cells do not have MHC 2 markers. Those are the ones that would cause an immunologic reaction. But they are not there, so the cells are “immunologically privileged.”
Another question often asked is “Is there a chance of a tumor forming?” Once again the answer is NO. The mesenchymal stem cells and exosomes used during treatment have never been shown to have tumor forming potentials. In fact, they have been shown to be anti-tumor forming.
For the past decade, R3 has been successfully treating CKD patients with IV stem cell and exosome therapy. The cells and exosomes are attracted to inflammation, which is a large component of CKD. So they will go predominantly to the kidney, but also, to areas that are experiencing disease as well.
So, for example, if a person has CKD secondary to diabetes, the cells and exosomes will also go to the pancreas to assist with function there too. There are Centers that promote injections directly into the kidney, or renal artery/vein. This is not necessary and entails additional risk!
R3’s providers will calculate the amount of stem cells based on patient weight and CKD severity. It will range from 1 to 3 million stem cells/kg. Depending on the total amount, treatment may need to be broken up into two sessions, three at the most for optimal safety.
R3 Stem Cell’s renal disease protocols are based on the latest research along with Best Practice Protocols developed over the past decade to help patients achieve the best outcomes possible. Safety is paramount with the biologics products being rigorously tested prior to use, and expert providers managing each treatment as if it was a family member!
Because stem cell therapy for CKD is not a permanent cure, it’s important to make it affordable. Repeat therapies can help maintenance and/or achieve additional improvements for CKD. So a lot of patients seek additional treatments at R3 Stem Cell every six to eighteen months.
Unfortunately, stem cell clinics in Colombia, China and Panama charge over $20,000 USD for CKD treatment. Because the one treatment cost so much, how are individuals supposed to budget for that every year?? R3 Stem Cell’s fees are less than half that for 100 million high quality stem cells!
Affordability
Because stem cell therapy for CKD is not a permanent cure, it’s important to make it affordable. Repeat therapies can help maintenance and/or achieve additional improvements for CKD. So a lot of patients seek additional treatments at R3 Stem Cell every six to eighteen months.
Unfortunately, stem cell clinics in Colombia, China and Panama charge over $20,000 USD for CKD treatment. Because the one treatment cost so much, how are individuals supposed to budget for that every year?? R3 Stem Cell’s fees are less than half that for 100 million high quality stem cells!
R3 Stem Cell offers free consultations for individuals to discuss whether regenerative therapy is indicated for their CKD. Simply call +1 (844) GET-STEM or (844) GET-STEM to schedule yours!
David Greene, MD, PhD, MBA, Founder/CEO
R3 Stem Cell offers treatments that bring patients hope and options. Hope that surgery can be avoided, and tissue injury can be repaired with patients being able to get back to desired activities.
Founder and CEO David Greene, MD, PhD, MBA writes extensively on regenerative medicine and gives many seminars worldwide on a regular basis. With over forty Centers of Excellence globally, R3 is at the forefront of regenerative therapies.
R3’s Centers have successfully performed over 25,000 regenerative procedures to date. Call today for your free consultation (844) GET-STEM!
No portion of this Document may be reproduced without the Express Written Consent of R3 Stem Cell.
This guide’s education does not constitute medical advice. The USA FDA considers stem cell therapy experimental. Any claims made in the Guide refer to procedures performed outside the USA.
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The information provided by R3 Stem Cell is not a substitute for professional medical advice, diagnosis, or treatment. Individual results may vary and only your medical professional can explain all the risks and potential benefits of any therapy based on your circumstances. R3 Stem Cell does not recommend or endorse any specific tests, products, procedures, opinions, or other information that may be mentioned on this website. Reliance on any information provided by R3 Stem Cell, its employees, others appearing on this website at the invitation of R3 Stem Cell, or other visitors to the website is solely at your own risk. R3 Stem Cell is not responsible for the outcome of your procedure. The FDA considers stem cell therapy experimental at this point.
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