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Psoriasis: More Than Skin Deep
Our therapy addresses the systemic inflammation causing both skin and joint symptoms. Stem cells and exosomes work together to modify immune response.
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Disclaimer:
The information provided by R3 Stem Cell is for educational purposes and is not a substitute for professional medical advice, diagnosis, or treatment. Individual results may vary and are not guaranteed. The FDA considers stem cell therapy experimental at this point.
Any claims made on this website refer to procedures performed OUTSIDE of the USA. R3 Stem Cell has clinics in Mexico, Philippines, South Africa, Turkey, India, Pakistan.
Every day, R3 Stem Cell receives inquiries worldwide from individuals asking if stem cell therapy can help with psoriasis. Spoiler alert: It can help a lot! In this guide, we’ll go through the basics of how stem cells and exosomes work for psoriasis, the latest research, and what to expect with a regenerative procedure.
Conventional treatments for psoriasis are often not able to stop the disease progression and control the topical plaques and joint erosion. For those who desire reduced pain along with improved skin appearance, failure with conventional treatments is disappointing and occurs all too often.
Stem cell therapy for psoriasis is turning out to be an excellent opportunity for individuals to achieve meaningful long-term results. Let’s dig in!
Tired of psoriasis flare-ups? Learn how stem cell therapy might help. Call (844) GET-STEM.
Psoriasis is considered a chronic, inflammatory, and immune-mediated systemic disease with involvement of both skin and other organs, including at least cardiovascular and articular systems and gastrointestinal district, with various degrees of involvement variable from patient to patient.
Psoriasis affects 0.51–11.43% of the adult population, and it is associated with a psychological burden that can lead to mental disorders, including depression and anxiety.
The phenomenon of the undertreatment and nontreatment of psoriasis is still diffuse worldwide, including Europe and the USA, and even worse in those developing countries where psoriasis patients with the moderate-to-severe disease have poor or not all access to these new expensive treatments. A recent global survey named “Clear about Psoriasis”
stated that 57% of moderate-to-severe psoriasis patients currently under treatment do not achieve clear/almost clear status, confirming earlier findings that most psoriasis patients worldwide are inadequately treated.
Chronic skin inflammatory diseases including atopic dermatitis (AD) and psoriasis have been considered uncontrolled inflammatory responses, which have usually troubled patients around the world. Moreover, the recent method to treat AD and psoriasis has been based on the inhibition, not regulation, of the abnormal inflammatory response, which can induce a number of side effects and drug resistance in long-term treatment.
Unlike AD, psoriasis accounts for approximately 1% of children and 11% of adults in an epidemiological study of 20 countries. Moreover, the age distribution of psoriasis has a bimodal onset including before the age of 40 years accounting for 75% of cases and after the age of 40 years for the rest.
An over-reactive immune system that creates inflammation in your skin causes psoriasis.
If you have psoriasis, your immune system is supposed to destroy foreign invaders, like bacteria, to keep you healthy and prevent you from getting sick. Instead, your immune system can mistake healthy cells for foreign invaders. As a result, your immune system creates inflammation or swelling, which you see on the surface of your skin as skin plaques.
Psoriasis runs in families. There may be a genetic component to psoriasis because biological parents may pass the condition down to their children.
Stop hiding your skin. Call R3 Stem Cell at (844) GET-STEM about psoriasis treatment options.
Traditional Treatments
Several treatment options can relieve psoriasis symptoms. Common psoriasis treatments include:
Several treatment options can relieve psoriasis symptoms. Common psoriasis treatments include:
There have been several studies published over the past few years showcasing just how well stem cells work for psoriasis. In 2022, Chang et al evaluated human umbilical cord mesenchymal stem cells for psoriasis in 18 patients.
At the sixth month, 47% had at least 40% improvement, 35% had more than 75% improvement and 18% had more than 90% improvement in the PASI score (Psoriasis Area Severity Index). However, the remaining 9 patients did not show significant improvement. Three patients showed no sign of disease (a score of 0) or minimal disease (a score of 1) based on the PGA score (Physician’s Global Assesment). Furthermore, we found that the efficiency of female patients (66.7%, 6/9) was higher than that of male patients (25%, 2/8), and we did not find significant differences in other aspects, such as the severity of the disease, between female and male patients.
In this study, the clinical trial demonstrated that the application of clinical-grade umbilical cord mesenchymal stem cells is safe and partly effective in patients with psoriasis, and the efficacy appears to be related to sex, with this treatment being more effective in women than in men. Among the 6 patients who had at least 75% improvement in PASI, 3 of the patients received a single dose of 1.5 × 106/kg, and the remaining 3 patients received a single dose of 2.0 × 106/kg, 2.5 × 106/kg and 3.0 × 106/kg, respectively.
However, the role of mesenchymal stem cells in vivo is not permanent. In the present study, recurrence occurred in 2 patients who had an improvement of PASI 90. They had disease relapse at 8 and 9 months, respectively, after the infusions. The recurrence may be ascribed to the limited duration of UMSCs and the persistence of pathogenic factors. A repeated UMSC infusion is feasible and necessary after several months to avoid disease relapse. Notably, one patient who had an improvement of PASI 90 at the 6-month follow-up maintained one-year relapse-free status without using any other traditional drugs.
Interestingly, we found that UMSC treatment for psoriasis was more effective in females, with a response rate of 66.7%. See various before and after pictures below.
In 2016, Chen et al. described two cases of psoriasis Vulgaris successfully treated with infusion of umbilical cord-derived mesenchymal stem cells (UC-MSCs) with remission maintained for 5 years without relapse.
More recently, Wang et al. treated a 19-yearold man with a 5-year history of severe plaque psoriasis refractory to multiple topical and systemic therapies with an infusion of allogeneic human mesenchymal stem cells. Complete regression was achieved after 5 infusions with no adverse reactions, and he experienced 3 years of disease-free status.
Psoriasis affecting your quality of life? Call (844) GET-STEM to discuss stem cell therapy.
Stem cells and exosomes act in the body through several mechanisms. They do NOT become part of a patient’s DNA, which means they do not engraft into the person’s existing cells.
Stem Cells can also release a huge variety of molecules into the extracellular environment. These molecules, which include extracellular vesicles (exosomes), lipids, free nucleic acids, and soluble proteins, exert crucial roles in repairing damaged tissue. Along with offering stem cells for treatment of psoriasis, R3 Stem Cell includes stem cell exosomes, which are a type of extracellular vesicle participating in extensive cell to cell communication for ovarian tissue repair and regeneration.
The stem cells administered by R3 are not the ones that become part of a patient’s DNA. The administered mesenchymal stem cells are not specifically designed to replace damaged and lost epithelial cells, but rather coordinate immune system modulation.
Where do the stem cells and exosomes come from?
R3 Stem Cell’s regenerative biologics originate from umbilical cord tissue that has been donated after a scheduled c-section. No baby (or mother) is harmed during the c-section procedure. The umbilical cord tissue is normally discarded, but if the mother passes screening test then the umbilical cord is immediately sent to the lab.
The lab carefully processes the umbilical cord to generate large amounts of stem cells and exosomes that are of the highest quality possible. The lab team consists of multiple PhD’s working in ISO Certified, cGMP compliant clean rooms to ensure quality assurance that exceeds USA FDA standards. The proprietary production process combines the highest potency, safety and affordability for providers to confidently offer exosome procedures.
Millions of dollars have been invested into the pharmaceutical grade production of the biologics including first rate clean rooms, bioreactors, nano-particle tracking analyzers, cytometers, PCR, tangential flow machines and real time environmental monitoring. The quality assurance testing complies with screening and testing stan¬dards consistent with the American Association of Tissue Banks, cGMP standards, FDA regulations and the highest level of any regulatory agency globally.
Psoriasis relief that lasts. Learn about our approach at (844) GET-STEM.
Stem Cell Derived Exosomes
R3 Stem Cell’s Centers of Excellence globally include umbilical cord stem cell derived exosomes with umbilical cord stem cells to provide enhanced results. Exosomes are lipid bound vesicles (acellular) produced by cells that contain a plethora of growth factors, cytokines, mRNA and other proteins.
They are exceptionally helpful in cell to cell communication, and very effective for reducing inflammation when they become ingested by their recipient cell. They act as shuttles to send nucleic acids and proteins to other cells, in this way, allowing cell-to-cell communication and transporting molecules among both close and distant cells. In general, these released proteins are important regulators of intracellular information.
Exosomes could be the mediators of many stem cell-associated therapeutic activities. Considering they are 100 times smaller than stem cells, they do not have any issues passing through the blood-brain-barrier to reach the brain from the bloodstream.
After a decade of performing over 24,000 stem cell procedures worldwide, R3 knows that the regenerative procedures are safe. The quality control employed during the stem cell production is second to none, and the side effects R3 sees are usually mild to moderate and temporary.
They may include itching, dizziness, lightheadedness, low grade fever, chills, headache, nausea. These are typically temporary. If a patient has an allergic reaction to the multivitamin or a preservative, all of R3’s Centers have the medications to resolve it quickly.
One of the questions we get asked a lot is, “Will the stem cells get rejected?” The answer is NO.
MSCs do not express major histocompatibility complex (MHC) antigens of the class II subtype and contain low levels of MHC molecules of the class I subtype. MSCs also lack the co-stimulatory molecules essential for immune detection, including CD40, CD80, and CD86.
Therefore, MSCs generally have low immunogenicity and can avoid immune rejection by the recipient, which serves as the foundation for their successful application without needing to match the donor to the recipient. Scientists call this being “immunologically privileged”.
Another question often asked is “Is there a chance of a tumor forming?” Once again the answer is NO. The mesenchymal stem cells and exosomes used during treatment have never been shown to have tumor-forming potential. In fact, they have been shown to be anti-tumor forming.
Treating both skin and joint symptoms of psoriasis. Call R3 Stem Cell at (844) GET-STEM.
Why does R3 Stem Cell use donor tissue for its stem cells?
Although autologous (your own) stem cells provide significant advantages, allogeneic (donor) stem cells have more advantages. First of all, autologous MSCs need a long time to culture and expand, which limits its application in treatment, while allogeneic stem cells can be obtained and expanded more quickly, thus avoiding the delay of time window.
Second, age is a factor that affects the physiological characteristics of MSCs. Studies have shown that stem cells from elderly donors have decreased proliferation and differentiation ability. This means they are less in number and less effective!
Affordability
Stem cell therapy for PD may be the key step in achieving a stoppage of disease progression along with functional improvements, and we want to make it affordable for as many individuals as possible. Our global volume has allowed us to keep our patient costs as low as possible. Especially considering that most patients will need repeat therapies every one to two years, treatment cost is extremely important.
Unfortunately, stem cell clinics in Colombia, China and Panama charge over $20,000 USD for PD treatment.
How are individuals supposed to budget for that?? R3 Stem Cell’s fees are less than half that for full treatment, which also includes free exosomes, PRP and a multivitamin infusion!
R3’s Experience
For the past decade, R3 Stem Cell’s Centers globally have performed over 24,000 regenerative procedures in six countries. Patient satisfaction across all conditions treated is very high, at 85%. However, MSC treatment for PD is a MUCH newer option, so satisfaction percentages haven’t been definitively established.
R3 combines safety, effectiveness and affordability for the therapies. Internationally, the Intellicell is used, which is culturing the most active mesenchymal stem cells to create the “smartest” stem cell in the world!
R3 Stem Cell offers free consultations for individuals to discuss whether regenerative therapy is indicated for your PD. Simply call (844) GET-STEM to schedule yours
References
David Greene, MD, PhD, MBA, Founder/CEO
R3 Stem Cell offers treatments that bring patients hope and options. Hope that surgery can be avoided, and tissue injury can be repaired with patients being able to get back to desired activities.
Founder and CEO David Greene, MD, PhD, MBA writes extensively on regenerative medicine and gives many seminars worldwide on a regular basis. With over forty Centers of Excellence globally, R3 is at the forefront of regenerative therapies.
R3’s Centers have successfully performed over 24,000 regenerative procedures to date. Call today for your free consultation (844) GET-STEM!
No portion of this Document may be reproduced without the Express Written Consent of R3 Stem Cell.
About R3 Stem Cell Disclaimer: This guide’s education does not constitute medical advice. The USA FDA considers stem cell therapy experimental. Any claims made in the Guide refer to procedures performed outside the USA.
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The information provided by R3 Stem Cell is not a substitute for professional medical advice, diagnosis, or treatment. Individual results may vary and only your medical professional can explain all the risks and potential benefits of any therapy based on your circumstances. R3 Stem Cell does not recommend or endorse any specific tests, products, procedures, opinions, or other information that may be mentioned on this website. Reliance on any information provided by R3 Stem Cell, its employees, others appearing on this website at the invitation of R3 Stem Cell, or other visitors to the website is solely at your own risk. R3 Stem Cell is not responsible for the outcome of your procedure. The FDA considers stem cell therapy experimental at this point.
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