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Amniotic Stem Cell Therapy for Diabetic and Peripheral Neuropathy

 
Amniotic Stem Cell Therapy for
Diabetic and Peripheral Neuropathy

By David Greene MD, MBA
Neuropathic Pain
Diabetic and Peripheral Neuropathy pain affect 6% of the population.
70% of diabetics suffer from neuropathy.
Pain is sharp, burning, lancinating, electric.
Not just pain, the decreased sensation affects walking ability.
Neuropathy Traditional 
Treatment Options
Opioids and NSAIDs
Oral and Topical
Questionable Benefit
Off label tricyclic antidepressants, anticonvulsants.
Neurontin, Lyrica
TENS unit
Only 30% achieve adequate relief with these methods.
Neuropathy Traditional 
Treatment Options
Spinal Cord Stimulator Implant
Revolutionary for relief and sensation return.
Over 80% pain relief.
85% improved sensation, 58% sensory deficits reversed completely.
Regenerative Medicine
The NEW paradigm, a nonoperative treatment that can actually repair damaged tissue. Provides pain relief and improved sensation.
Low risk, outpatient, effective – isn’t that what medicine has been looking for?
Consider this:
20 years ago plastic surgery was 90% operative. Now it’s 90% nonoperative!
Regenerative Options for
Diabetic and Peripheral Neuropathy
PRP Therapy
Blood draw, spun in centrifuge concentrates platelets/growth factors.
Bone Marrow
Adipose (fat)
The newest – Amniotic
Not really new
Used for decades
Amniotic Stem Cell Therapy
Remarkable addition to regenerative medicine.
Obtained from consenting donors after scheduled c-section.
FDA Regulated (CGTP)
AATB Certified
Cryogenically Frozen
No embryonic cells or fetal involvement
Amniotic Qualities
Immunologically Privileged
No Rejection Reaction
Growth Factors
Hyaluronic Acid
Stem Cells and Activators
Antimicrobial
NONsteroidal
Protocol
Amniotic stays on dry ice or in cryogenic freezer until ready to use.
Thaw for 10 minutes.
Usually 1-2 cc’s per limb, ok to dilute 3:1 with sterile water/saline/lidocaine.
Procedure takes less than a half hour.
Outcomes
We know that mesenchymal stem cells in animals significantly reduce neuropathic pain.
A preliminary report on stem cell therapy for neuropathic pain in humans – J Pain Res 2014
10 pts, In this preliminary proof-of-concept study, the administration of a mixed population of adipose-derived cells, including MSCs, was shown to be able to attenuate orofacial neuropathic pain symptoms in a diverse range of patients considering variables of age and the established duration of the pain state.

Outcomes
Anti-Inflammatory Mesenchymal Stem Cells (MSC2) Attenuate Symptoms of Painful Diabetic Peripheral Neuropathy 2012 Stem Cells Transl Med.
Over 40% inflammatory and pain reduction in mice.
Related to their capacity to not only control pain as a symptom, but to modulate the neuroimmune component which plays a relevant role in neuropathic pain.

Risks
Risks have been absolutely minimal.
Have not seen rejection
NO steroid.
It’s antimicrobial so risk of infection has been minimal.
Coverage
Currently amniotic stem cell therapy for neuropathy is an out of pocket expense.
Insurance will cover the visits, imaging, lab work but NOT the amniotic material.
New technology takes a while to capture reimbursement.
Bottom Line
Amniotic therapy works in preclinical studies and in early human pilot studies.
It is low risk, potential high benefit, and has live cells depending on processing.
No embryonic stem cells or fetal involvement!
Can help you and your loved ones avoid surgery and achieve relief and walk better.
R3 Stem Cell
R3 partners with top providers nationwide to offer regenerative treatments for all types of musculoskeletal conditions – knee, hip, shoulder, ankle, elbow, wrist, etc.
This includes back and neck conditions as well as neuropathy.
Visit us at R3StemCell.com and call us to find a treatment center at (844) GET-STEM.

What are the Benefits of Stem Cell Therapy?

A small number of stem cells taken from the body can grow in the laboratory setting to create millions of new stem cells. Known as regenerative medicine, stem cell-based therapies hold the promise of replacing and repairing damaged and disease body structures.

What ethical issues are associated with adult stem cell therapy?

Adult stem cells do not come from embryos. They cannot develop into a new human being. Rather, these cells reside in the fat and bone marrow in large quantities.stem-cells2

How do I know if stem cell therapy is right for me?

Consult with your orthopedic specialist if you suffer from a degenerative disease, have an acute injury, or have chronic joint pain. Stem cells come from the patient’s own body, and these cells help heal and repair damaged tissues.

What are the side effects of stem cell therapy?

Stem cell therapy is a safe procedure. After you undergo a medical evaluation, the specialist will determine if you are a candidate for this particular therapy. Some patients experience soreness and pain right after the procedure. However, because autologous (from the patient) fat and blood are used, there is no chance for allergic reaction.

What are the benefits of stem cell therapy?

Repair, healing, and regeneration of damaged or injured tissue are the main benefits of stem cell therapy. Stem cells can regenerate tissues that are injured, such as ligaments, menisci, and the rotator cuffs. In addition, tissues that are chronically damaged can be repaired from diseases such as osteoarthritis, tennis elbow, and bursitis. Stem cell therapy is a procedure offered in the office setting using local anesthesia, which eliminates the risks associated with general anesthesia.

How do stem cells from fat differ from those derived from bone marrow?

Adipose (fat) stem cells and stem cells from bone marrow both are adult mesenchymal stem cells. Adipose stem cells are collected bone marrow aspiration2form a mini-liposuction procedure, whereas bone marrow stem cells are aspirated from the hip bone. While adipose stem cells have regenerative properties to make blood vessels (essential for nutrient and oxygen delivery to tissues), bone marrow stem cells have superior ability to differentiate into cartilage, ligaments, and bone.

How do I prepare for the stem cell therapy procedure?

To prepare the body to better receive the stem cells, we encourage patients to undergo a simple detox before the treatment. This involves stopping smoking, avoiding alcohol, and taking vitamins, which cleanses the system from toxins.

How is the stem cell injection done?

To assure correct placement, stem cell injections are done using fluoroscopy (x-ray guidance), which allows the doctor to visualize the site of injury and offer effective, accurate treatment. After cleansing the skin with an antiseptic solution, the needle is guided into the treatment region, and the stem cells are injected.

How soon can I go back to usual activities after stem cell injection?home_service01

The procedure is done outpatient, so you are allowed to leave the medical facility that day. Patients are typically sore during the first couple of days following the injection, but they can return to work after 3-4 days. This depends, however, on the site of treatment and the type of physical activity required for the patient.

Are stem cell injections effective?

In recent research studies, intra-articular stem cell injections for arthritis have been investigated. Studies used both bone marrow-derived and adipose-derived stem cells. Researchers found that injection of stem cells allowed for improvement in pain scores, increased range of motion, and better outcome scores at 6-12 months post-procedure. In addition, researchers found that participants had increases in cartilage growth and thickness, which were evident on MRI.

Resources

Centeno CJ, Busse D, Kisiday J, Keohan C, Freeman M, Karli D. Increased knee cartilage volume in degenerative joint disease using percutaneously implanted, autologous mesenchymal stem cells. Pain Physician. 2008;11(3):343–353.

Davatchi F, Abdollahi BS, Mohyeddin M, Shahram F, Nikbin B. Mesenchymal stem cell therapy for knee osteoarthritis. Preliminary report of four patients. Int J Rheum Dis. 2011;14(2):211–215.

Emadedin M, Aghdami N, Taghiyar L, et al. Intra-articular injection of autologous mesenchymal stem cells in six patients with knee osteoarthritis. Arch Iran Med. 2012;15(7):422–428.

Orozco L, Munar A, Soler R, et al. Treatment of knee osteoarthritis with autologous mesenchymal stem cells: a pilot study. Transplantation. 2013;95(12):1535–1541.

Varma HS, Dadarya B, Vidyarthi A. The new avenues in the management of osteo-arthritis of knee – stem cells. J Indian Med Assoc. 2010;108(9):583–585.

FAQs on Amniotic Stem Cell Therapy

Amniotic fluid is highly concentrated in proteins, cytokines, stem cells, and other components that are useful for the boy. Clinical studies show that amniotic fluid and stem cells have many benefits.stem-cells2

What are amniotic stem cells?

Amniotic fluid is the fluid that surrounds the fetus during pregnancy. After delivery of the baby, the amniotic fluid is disguarded. Now, many consenting mothers are donating this fluid because of its regenerative stem cell properties. Amniotic stem cells are useful for reducing inflammation and scar tissue. These stem cells do not come from the embryo, but rather, they are in the fluid and the amniotic sac.

What are the benefits of amniotic stem cell therapy?

Amniotic stem cell therapy is an effective, safe treatment with absolutely no risk for rejection to the patient. The fluid contains many growth factors that stimulate new tissue growth, reduce inflammation, and activate stem cell properties. In addition, amniotic fluid contains hyaluronic acid, which serves as a joint lubricant and promotes growth of new cartilage.

Who is a candidate for amniotic stem cell therapy?

Amniotic stem cell therapy is ideal for patients who have:

  • Soft tissue or intra-articular injuries, including cartilage and meniscus
  • OsteoarthritisBackPain copy
  • Achilles tendon tears
  • Sacroiliac pain
  • Ligament or tendon tears
  • Epicondylitis
  • Rotator cuff injuries
  • Tennis elbow and golfer’s elbow
  • Joint pain
  • Low back pain
  • Neck pain

How is amniotic stem cell fluid obtained?

When the fetus is developing, the amniotic fluid contains a high concentration of stem cells. The fluid has more stem cells than bone marrow and adipose (fat) tissue. The fluid is obtained during a caesarian delivery, and the stem cells are harvested in a centrifuge process in the laboratory. After an activation solution is added, they are processed to produce the biological injectable fluid. This injection produces anti-inflammatory agents when placed into the injured or damaged body region.

Can amniotic stem cells help with back problems?

Currently, amniotic stem cell therapy is being used as a form of spinal fusion, where back surgery has failed to relieve pain or for people who are not candidates for spinal fusion surgery. These products surround the spinal cord to inhibit scar tissue formation. Favorable results show that these injections help with degenerative arthritic pain, where tissue is regenerated after 1-3 injections.

Are amniotic sR3 Horizontal smaller logotem cell injections safe?

Thousands of amniotic stem cell injections have been performed with no reported adverse side effects. Amniotic stem cell therapy is actually the preferred method because the cells are derived from an immune-privileged site. The use of these cells is well-researched, effective, and safe, approved by the Food and Drug Administration (FDA) and American Association of Tissue Banks (AATB).

Is amniotic stem cell therapy effective?

In a large study of patients with chronic discogenic back pain, researchers conducted a randomized controlled study. In the amniotic stem cell therapy group, patients showed much improvement of pain after treatment. All participants reported improvement after the 3rd and 6th months, and two-thirds continued to have improvement after one year. The amniotic fluid cell therapy group had a much more sustained effect compared to the long-acting steroid group in this study.

Resources

Bhattachary N (2012). Amniotic Fluid Cell Therapy to Relieve Disc-Related Low Back Pain and Its Efficacy Comparison with Long-Acting Steroid Injection. Human Fetal Tissue Transplantation, 251-264.

An Overview of PRP Therapy: How It Works and What It Does

Platelet rich plasma (PRP) therapy is being utilized increasingly to help enhance and encourage the healing process for those who have soft tissue and bone injuries. PRP has received increased attention from the media as it has been used to help high profile athletes who have suffered injuries mend more quickly and efficiently. It has been effective in reducing inflammation and in boosting cell proliferation, both of which are important aspects of the healing process.

Defining PRP

PRP is derived from one’s own body, coming directly from a person’s blood. It uses one kind of cell that is found in the blood, platelets. PRP is a substance that has a heavy concentration of these cells, which circulate within the blood and are an important factor in clotting. Plasma, which is also found in our blood and is aprp2
component in PRP, is involved in providing the body with key substances. Together platelets and liquid plasma, which combine to create PRP, are important in that they possess certain factors that help in the enlistment, multiplication, and specialization of cells, all of which are essential to the healing process.

PRP Therapy

PRP therapy begins with blood being drawn from the patient; it is then placed in a centrifuge where it is spun in order to separate the blood into its various components. The plasma, which is platelet rich, is collected and treated prior to being administered to the injured region.

When a patient undergoes PRP therapy they are given injections in the area of injury. When administering the treatment a healthcare professional will often utilize ultrasound guidance to ensure accuracy in treating the specific bone or soft tissue region, which may be a designated ligament or tendon.

After the patient receives the injection, there is a short period of time where they will avoid all exercise. After that, they begin an exercise program designed to physically rehabilitate the injured area.

Efficacy of PRP

There is evidence based on scientific studies focusing on animals in which therapy that uses PRP has been revealed to be effective in aiding the healing of bone and soft tissue. As an example, in calf muscle injuries in which the Achilles tendon has been damaged there has been evidence of increased numbers of cells and heightened PRP-2tendon strength. Also, increased muscle regeneration has been noted.

There have also been promising but limited studies involving humans. PRP therapy was revealed to be efficacious in a small study focusing on knee osteoarthritis. In this study PRP was shown to be more effective than hyaluronic acid treatment. In addition, there have also been positive results in treatment with PRP that focuses on rotator cuff tears and medial collateral ligament (MCL) knee injuries.

However, there is also a study published in the Journal of the American Medical Association that noted there was no advantage to utilizing PRP injections when compared to placebo injections of saline for the treatment of Achilles tendinosis. Still, despite the lack of of evidence as to the efficacy of PRP, it has started to take root as a treatment that can aid in the healing process due to the fact that it carries an extremely low-risk and the substance used is derived directly from the patient’s blood.

With promising results in animal models, there has been increased activity in using PRP for various conditions, including chronic and acute tendon issues and injuries to muscles and ligaments. Conditions that have responded especially well to PRP include those related to lateral epicondylitis (tennis elbow) and Achilles tendinosis, which affects the Achilles tendon.

As more studies are developed regarding the use of PRP and more evidence becomes available as to its effectiveness, it’s anticipated that the therapy will become more widespread. Also, studies will go a long way to helping to standardize treatment.

Cautions Regarding Treatment

Although PRP therapy involves minimal risk, there are certain cautions that should be taken when utilizing this type of approach. When undergoing treatment all anti-inflammatory medications should be stopped, as PRP is designed to aid in the reduction of inflammation and aid in healing. Also, athletes who will be involved in certain competitions need to be aware that PRP contains endogenous growth factors, which certain agencies, such as the World Anti-Doping Agency and the United States Anti-Doping Agency, forbid. This is due to the possibility that PRP might enhance one’s performance, although there is no evidence of such.

Considering PRP Therapy

There are some important points to remember concerning platelet rich plasma (PRP) therapy, including that this is a substance that is extracted from the injured party’s blood, and comprised of components in their blood, specifically platelets and plasma. PRP contains a high concentration of growth factors (at least 7) and of those factors involved in cellular signaling, both of which are considered to be important in aiding the healing process.

An increasing amount of human studies are attesting to the effectiveness of PRP therapy for soft tissue injury, arthritis, tendonitis, ligament tear healing and more. Call (844) GET-STEM to find a PRP therapy treatment center today!

FAQs on Amniotic Stem Cells for Diabetic Foot Ulcer Treatment

What is a Diabetic Foot Ulcer?

People who suffer from diabetes are at risk of developing ulcers on their feet. Diabetic foot ulcers affect up to 15 percent of diabetic patients, and over 80 percent of lower leg amputations are done in the treatment of this condition.

What causes a Diabetic Foot Ulcer?

Diabetic foot ulcer is a complication resulting from physiological changes due to the patient’s diabetes mellitus. Due to diabetic foot ulcerthe vascular pathologies and neuropathy that results from diabetes, wound healing is compromised.

  • Diabetes is thought to cause changes in the bony architecture of the foot, leading to predisposition to injury. The glycosylation from diabetes causes the ligaments to be stiffer, leading to loss of coordination and control of foot movements. The increased mechanical stresses on the foot from this condition can cause small, undetected wounds that can eventually lead to diabetic foot ulcer.
  • There are changes in the vasculature, including atherosclerosis (stiffening of the blood vessels), calcification of arteries, and thickening of capillary basement membranes. The compromised blood flow leads to poor healing of injuries, such as wounds and breaks in the skin. Rather than being replaced by normal tissue, tissue degeneration and ulceration occur.
  • Another complication of diabetes is peripheral neuropathy, leading to decreased sensation around the foot. Due to this loss of sensation, injuries to the foot are not noticed, often until too late.

What is the standard treatment for diabetic foot ulcers?

The treatment of diabetic foot ulcers is complicated and requires a multi-specialty team composed of orthopedic surgeons, internists, and rehabilitation specialists. The standard treatment of diabetic foot ulcer is the administration of antibiotics to prevent infection, debridement of damaged tissues, and proper wound dressing.

How are amniotic stem cells used in the treatment of diabetic foot ulcers?

Stem cell therapy for the treatment of diabetic foot ulcers is based on the goal of promoting better wound healing and cellular reconstruction with pluripotent cells. Among the many kinds of stem cells that are being explored for treatment are mesenchymal stem cells, which are derived from the amniotic membrane, as well as other tissue types, including bone marrow, umbilical cord blood, and fat tissue.

Mesenchymal stem cells are among the most commonly studied stem cells. They have been shown to differentiate into many different kinds of tissue. They are easy to collect and do not elicit a strong immune response. Studies have shown that the transplantation of mesenchymal stem cells has positive effects on diabetic foot ulcers, which include:

  • Cell proliferation
  • Collagen synthesis
  • Release of growth and healing factors[ File # csp9441400, License # 2035621 ] Licensed through http://www.canstockphoto.com in accordance with the End User License Agreement (http://www.canstockphoto.com/legal.php) (c) Can Stock Photo Inc. / 72soul
    • Angiopoietin-1
    • EGF
    • KGF
    • TGF-beta1
    • VEGF
    • SDGF-1alpha
    • IGF-1
    • IL-8
    • PDGF
  • Growth of new blood vessels
  • Wound contraction

Amniotic stem cells have been used clinically for diabetic foot ulcers extensively over the past decade. Whereas traditional treatments work slowly for healing diabetic ulcers, the amniotic therapy often heals them much quicker.

With the amniotic fluid being so readily available and having no rejection, it’s a great option as there is often a problem using a diabetic individual’s own bone marrow adipose tissue for stem cell therapy. For that reason, the “ready to go” amniotic therapy is excellent!

References

Blumberg SN, Berger A, Hwang L, Pastar I, Warren SM, Chen W. The role of stem cells in the treatment of diabetic foot ulcers. Diabetes Res Clin Pract. 2012 Apr;96(1):1-9. doi: 10.1016/j.diabres.2011.10.032.

Futrega K, King M, Lott WB, Doran MR. Treating the whole not the hole: necessary coupling of technologies fordiabetic foot ulcer treatment. Trends Mol Med. 2014 Mar;20(3):137-42. doi: 10.1016/j.molmed.2013.12.004.

Stem Cell Procedures for Achilles Tendonitis and Tears

The Achilles tendon is a common point of vulnerability for athletes in particular, whether professional, collegiate, or the weekend recreational dilettante. When it is strained, there is no thought of continuing activity until it rests. If the tendon tears, walking off the field is an exercise of excruciating pain. The large tendon on the back of your ankle, just above the heel Achilles Tendon Tears1connecting the heel with your calf muscle is the Achilles tendon. Flexing, stretching, jarring starts and stops all run it through its paces, usually with no repercussions. However, when tendonitis strikes, or the connecting tears, serious repairs are absolutely necessary.

A torn Achilles tendon most likely requires surgery to repair a tear or reattach the tendon. The area needs to be immobilized during recovery and physical therapy following regained mobility. Total recovery, if it occurs, depends on many factors; the procedure and therapy. The tendency of most athletes is to get back into the game as soon as possible. When a mending Achilles tendon is taxed before total healing, the chances of re-injury are high. The more often the tendon is ripped or strained, the less recovery one will realize.

The key to permanent recovery from an Achilles injury is to let it heal, thoroughly.

Today, thanks to stem cell procedures, there is a way to quicken the healing process and heal stronger when recovering from Achilles injuries. Stem cells are self-renewing cells extracted from the patient:

Your own cells contribute to your own recovery, which makes perfect sense.

A qualified physician or specialist simply harvests stem cells from bone marrow extracted from the hip area, and depending on r3_condition11the injury, may combine it with platelet rich plasma, also from the patient himself. When combined, these fresh, concentrated cells are injected into the injured area and assimilate naturally to start regenerating damaged tissue.

Additional treatment options include amniotic derived stem cell therapy for achilles tendonitis or adipose derived. All have been shown to work very well.

Typically, the procedure for stem cell treatment of Achilles tendon tears and injuries required one to three injections and probably will include physical therapy. However, because the cells are natural healers and self renew, tears mend stronger and faster than without stem cell treatment. There is a little chance of cell rejection, because the cells belong to the patient. Disease transmission is highly unusual; the stem cells come from his own immune system. Research is ongoing, but the results have been consistent.

Of course, prevention is the best remedy for Achilles tendonitis or tendon tears, but injuries are unpredictable and active people are enthusiastic. Consult with a trainer or coach to learn the measures of preconditioning prior to working out. In addition, don’t forget a healthy regimen after exercising, warming down is just as important as warming up. Ironically, when you treat your body well, it returns the favor. It is good to know that even when an injury like Achilles tendonitis or an Achilles tear occurs, you can use your own healthy and rich stem cells to help heal strong.

If you have an acute or chronic achilles pain issue bringing you down, let R3 Stem Cell help you. We have nationwide Centers of Excellence that can help you achieve relief with stem cell therapy for achilles tendonitis and tears!

FAQs on PRP Therapy for Rotator Cuff Injury

What is rotator cuff injury?

Your shoulder is a ball and socket joint that connects your humerus (upper arm bone), scapula (shoulder blade), and clavicle (collarbone). The rotator cuff refers to the muscles and tendons that keep the shoulder in place, namely, the supraspinatus, infraspinatus, teres minor and subscapularis muscles and tendons that cover the head of the humerus.rotator cuff bursitis

The rotator cuff can be damaged from acute injury, or through progressive degeneration and overuse. The damage can range from muscle or tendon strain, to a tear of the rotator cuff tendons. Tears of the rotator cuff tendons can be partial or full-thickness.

What is the standard treatment of rotator cuff injury?

Conservative treatment options are preferred whenever possible for rotator cuff injury. If the injury is not too severe, it can be managed with a program of rest, ice therapy, compression and elevation. Analgesic medications can also be prescribed to relieve pain symptoms, as well as to reduce inflammation. Physical therapy and rehabilitation may be recommended to improve the strength and conditioning of the stabilizing muscles.

Patients suffering large or complete tears, or weakness and reduced functionality of the joint may require surgical intervention. While surgery usually results in decreased pain and improved function, significant failure rates are noted at long-term follow up consults. It is theorized that failure rates can be attributed to the poor vascularity and cellular infiltration of the tendon, leading to poor wound healing and repair.

How is PRP used in the treatment of rotator cuff injury?

Platelet-rich plasma therapy contains a high concentration of the following growth and repair factors:

  • platelet-derived growth factor
  • transforming growth factor beta
  • fibroblast growth factorShoulder pain
  • insulin-like growth factor 1
  • insulin-like growth factor 2
  • vascular endothelial growth factor
  • epidermal growth factor
  • Interleukin 8
  • keratinocyte growth factor
  • connective tissue growth factor

PRP is derived from the patient’s own blood: after drawing the necessary amount for PRP, the blood is concentrated in a centrifuge. The centrifuge splits the blood into three laters: (1) the top layer of plasma; (2) the platelets and white blood cells (also known as “the buffy coat”); and (3) the red blood cells. It is the second layer that is used for PRP.

PRP injections may be anywhere from three to eight times as concentrated as normal blood. This will be injected into the damaged area to stimulate growth and regeneration of health tissue, as well as to promote increased blood supply and tissue repair.

Should I get PRP for my rotator cuff injury?

The proponents of PRP claim that this intervention allows the body to recover within a shorter period of time compared to routine treatment. Early clinical trials have also shown that PRP can be effective in reducing pain and improving function. However, PRP still remains in its experimental stage, and there are no large-scale studies that have clearly demonstrated its effectiveness and safety. PRP should be considered an experimental procedure that can be chosen if the standard treatment options have already failed.

R3 Stem Cell’s Centers of Excellence offer PRP therapy for shoulder conditions of all types, call us today for top treatment!

References

Barber FA. Platelet-rich plasma for rotator cuff repair. Sports Med Arthrosc. 2013 Dec;21(4):199-205. doi: 10.1097/JSA.0b013e31828a7c6a.

Moraes VY, Lenza M, Tamaoki MJ, Faloppa F, Belloti JC. Platelet-rich therapies for musculoskeletal soft tissue injuries. Cochrane Database Syst Rev. 2014 Apr 29;4:CD010071. doi: 10.1002/14651858.CD010071.pub3.

Scarpone M, Rabago D, Snell E, et al. Effectiveness of Platelet-rich Plasma Injection for Rotator CuffTendinopathy: A Prospective Open-label Study. Glob Adv Health Med. 2013 Mar;2(2):26-31. doi: 10.7453/gahmj.2012.054.

Bone Marrow Stem Cells and Adipose Tissue Stem Cells: Important Differences

It’s interesting to note that the debate over which, if either, is better, bone marrow stem cells or adipose tissue stem cells, is a hot one. Over the years, doctors have used stem cells increasingly to treat soft tissue, cartilage, and joint injuries, as well as other health problems and challenges. These powerful cells, when isolated and combined with other factors, aid in accelerating the body’s natural healing process. The two primary sources for these cells are bone marrow and adipose (fat) tissue.

Bone Marrow Versus Adipose Tissue Cells

Although the mesenchymal stem cells derived from bone marrow and adipose tissue were both able to differentiate into bone, fat, and cartilage, adipose tissue stem cells multiplied bone marrow aspirationmore quickly than their counterpart, and more could be harvested at once. Plus, they were 10 times larger than those associated with bone marrow. Plus, a problem for some doctors is that when bone marrow stem cells are harvested fairly few are captured when compared to those in fat tissue. That’s because they are less concentrated.

However, a major concern for many is the method of harvesting. Of course, stem cells are taken from the person who will be treated with them. Adipose tissue stem cells are collected through liposuction, while bone marrow stem cells are taken through the process of aspiration. Patients who underwent liposuction in order to donate cells had a complication rate of 8.6%, while those who underwent the process of bone marrow aspiration experienced no complications. There are significantly more stem cells in adipose tissue, though, so it’s not clear which is best. The bone marrow aspiration can be uncomfortable as it entails a larger needle.

The Defining Difference

The primary factor in determining which type of cell is better for treating certain injuries and problem is the structure of the cell itself. What has been found is that it’s best to use stem cells that mimic or can recreate the same structure of those cells being repaired.

bone marrow aspiration2It is unclear which type of cell is better at this recreation. It is known though, that adipose has a higher number of stem cells available, which may make it more preferable.

Preferred Method

If you are seeking help through stem cell therapy, you will want to know which method of harvesting will be used. The choice of method can affect your recovery time and complication rate, the effectiveness of the therapy, and the potency of the stem cell injection.

In terms of which type of stem cell is used, bone marrow stem cells or adipose tissue stem cells, the choice may be yours, or up to the physician’s experience. Listen carefully to your doctor and consider the various factors and benefits involved.

Ultimately what you want is the procedure that will be most effective and that involves the least amount of risk. And remember, to a degree, you will be making your decision based on the opinion of your doctor. Contact an R3 stem cell clinic today!

Amniotic Stem Cell Therapy for Hip Arthritis and Injuries

Treatment for hip arthritis and injuries does not necessarily have to rely on the use of synthetic drugs from time to time. In fact, the assertion that surgery will always be the last course of action is something that should not even happen in the first place. At least with amniotic stem cell therapy, these are possibilities that patients do not have to live through anymore.

The prospect of surgery shudders a lot of people, and the cost of synthetic medication to take away the pain from time to time can become unbearable over time, especially for those who are not able to afford proper medical insurance covers.

However, through this regenerative procedure, individuals are now able to access cutting edge treatment options, which enhance repair of the damaged ligaments, tendons and cartilage. These treatments actually help the body naturally restore itself to optimal functionality.

How amniotic cell therapy is changing the game

Well, all these are possibilities that do not have to be the case anymore. Through the use of amniotic cell therapy, individuals no longer have to struggle with some of these challenges anymore.

Invasive surgery is no longer a must experience as a last resort to helping you get relief from pain. Pharmaceutically this procedure has actually worked for so many patients in the past, and it is worth admitting that the future is bright so far for such treatments.

The National Institute of Health actually considers stem cell therapy to be one of the most promising alternatives to invasive therapy so far. This is because not only does it promote healing, but it is also a natural way to achieve the healing that you need so much.

Thousands of patients who have often shied away from invasive surgery are now seeking help from therapists and doctors who have specialized in amniotic stem cell therapy, and with time, it is becoming more convenient for the patients.

What does it do?

For those who suffer from hip arthritis or injuries, it is important to understand that these stem cells are actually available in all of our bodies. They have always been in the body from the moment you were conceived, and act every other time to help in regeneration of cells and tissues that have been used up or damaged through infection.

What these cells basically do is that they adapt where they are needed and transform themselves to become a copy of the cell that has been depleted, so that they can spur the body to heal itself. It is all part of a natural healing mechanism.

Through their regenerative ability, the stem cells have come in handy in naturally healing injured ligaments, bones, tissue and tendons. Take note that when you are injured or as a result of the natural aging process, the cells that are needed in a specific part of the body for normal operation tends to decline, and it is for this reason that amniotic stem cell therapy comes in handy.

What’s the difference between PRP therapy and stem cell therapy?

In the world of regenerative medicine, both platelet rich plasma therapy and stem cell therapy are now mainstream.
They are both effective and widely used for both degenerative arthritis and soft tissue injuries to tendons and ligaments. However, there is a distinctivprp2e difference between them.

PRP therapy involves utilizing a patient’s own blood from a simple blood draw in the office. The blood is then placed into a centrifuge and spun rapidly for about 15 minutes. The result is a concentrate that includes about seven different growth factors along with a lot of platelets.

In actuality, it does not have many stem cells at all in the final result. It is then injected into the problem area such as the knee, shoulder or hip. Once injected, it does call in the body’s own stem cells for repair, but there’s not a large amount in the PRP itself.

When looking at stem cell therapy, that is the major difference. Bone marrow or adipose derived stem cell treatments contain a large amount of stem cells, along with amniotic derived stem cells as well.

Not only do these materials contain a large amount of stem cells, there are also a considerable amount of growth factors as well. What this does is elevate the healing potential along with doing a lot of the same things that PRP therapy has as well.
Because the stem cell material is more difficult to obtain, there is a significant cost differential in the procedures. While PRP therapy runs between 500 and $1100, stem cell therapy is between $2500 and $5000.

Results with both PRP therapy and stem cell therapy have been exceptional to date in small studies. This includes treatment for degenerative arthritis, rotator cuff tendinitis, if arthritis, spinal arthritis and degenerative disc disease.
There are quite a few physicians who actually administer both treatments together for adjunct of results.

R3 Stem Cell is the nation’s leading clinics for stem cell therapy, call us today to find a center close to you!

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