Call US NOW (844) GET-STEM

Call US NOW (844) GET-STEM

Stem cell treatment for Congestive Heart Failure

Heart failure is a serious medical condition in which the heart is unable to effectively pump blood throughout the body for its normal function. It has a wide range of structural, electrical or functional causes. Common causes include cardiomyopathy, hypertension, heart valve problems and coronary artery disease.


Treatment for various types of heart failure depends on its underlying cause and severity, and may include a combination of lifestyle changes, medications, implantable devices and surgical procedures.


Despite major advances in medicine over the past decades, CHF therapy options are underwhelming in the results they produce. CHF is still related to unacceptably high death rates. Current CHF treatment may improve symptoms and signs, to reduce heart failure-related hospital admissions, and above all to improve patients’ survival, but there is no definitive cure.

most recent trial show that patients receiving stem cell therapy had significantly improved heart function

Stem cell therapy for CHF

Stem cells are body’s own pluripotent cells that are able to differentiate into specific cells, such as cardiomyocytes. In the setting of heart failure, stem cells can replace damaged cardiac muscle tissue and promote healing through growth factors. Mesenchymal stem cells can be harvested from human umbilical cord tissue and injected into the failing heart.
All stem cells are screened for infectious diseases and cleared for use in patients. Patient’s own stem cells, derived from the bone marrow, can be used as well but they have been to have a modest benefit.


Overall, chances of success can be improved by giving more highly selected stem cells from a donor around the time of a heart attack, or giving a patient’s own cardiac stem cells late after a heart attack.

Stem cell therapy for CHF has yet to be proven fully safe and their benefits fully established. Randomized clinical trials evaluating these different approaches are underway and promising results are beginning to emerge.


Results from the most recent trial show that participants receiving stem cell therapy had significantly improved heart function than those who did not. It was also associated with significant improvement in symptoms, such as fatigue and shortness of breath. Furthermore, no adverse events were found to be associated with stem cell therapy. These studies are showing promising results regarding the improvement of the heart’s ejection fraction, patients’ functional capacity, and quality of life. These results were seen with non-ischemic HF. It also appears that there is no “fit-all” stem cell therapeutic approach, and future therapeutic strategies involving stem cells will be more personalized to the patient’s condition, including its underlying causes and clinical stage.


These early results have been encouraging but evidence from more large-scale trials will need to be seen before stem cell therapy can be considered as a fully validated treatment for symptomatic patients with CHF.

Causes of Death in Dementia Patients

Dementia is a progressive neurological condition. It doesn’t just cause memory loss, but also damage to other parts of the brain, which are responsible for controlling our vital organ-systems This is why, eventually, it causes death.


Common causes of dementia include Alzheimer’s disease, Lewy body dementia, vascular dementia, Huntington’s disease, etc.


Late stage of Dementia:

Dementia is divided into three main stages based on its clinical progression: early, middle and late stages. We are going to focus the late stage that culminates in death.


There are four symptoms of late-stage dementia:

  • Increased frailty (typically brought on by comorbidities, such as arthritis or a stroke)
  • Severe memory loss
  • Total reliance on others
  • Severely limited communication


Causes of Death in dementia patients:

As our aging population grows, it means that more people are living longer, more likely to develop dementia, and with improved understanding and awareness, more are getting diagnosed with it.

Patients with dementia often die of a medical complication, such as pneumonia. But dementia itself can be fatal as the aforementioned late-stage symptoms can lead to death. As these patients become increasingly frail, their immune system is weaker, their appetite and diet poorer, their gait worsened, healing impeded, and their muscles and bones weaker, making them prone to serious infections (pneumonia, wound infections) and injuries (related to fall).

Caring for people with dementia at home can be demanding and stressful for anyone

When dementia patients are near death, they encounter irregular breathing, inability to swallow, cold hands and feet, agitation or restlessness, and frequent bouts of unconsciousness.

Support for Late-stage dementia:

Caring for people with dementia at home can be demanding and stressful for the caregiver. They commonly encounter fatigue and depression while having to dedicate more time and energy to their loved ones. Hospice and other support systems provide caregivers the needed support near the end of life of the dementia patients.


Caregivers need to decide whether they can manage their loved one’s condition at home or require skilled care facility or hospice. There are home care services, palliative care, and home hospice care services that provide the needed equipment, assistance, therapy, and medications.


Preventing potentially fatal complications:

A special focus should be placed on preventing infections, as they are the leading cause of death in this group. This includes keeping the person’s mouth and teeth clean, treating cuts immediately, checking for pressure sores, and keeping them warm and comfortable. Patients should get a flu vaccine each year and a pneumococcal vaccine every five years. Regular visits from the GP and nurse skilled in palliative care are required.


A physical therapist can help educate caregivers on how to transfer the person safely, change position in bed, and do range-of-motion exercises to prevent stiffness and pressure sores. Accessories such as lifts, transfer belts, wedge-shaped cushions and special mattresses that help prevent pressure sores can all be very useful in these settings.

Ankle Arthritis Pain Relief

Ankle arthritis common in aging adults, but it can occur in younger people due to an ankle injury. It is a chronic, painful condition that has few treatment options. There are now stem cell and platelet treatments for foot and ankle injuries and degenerative conditions.



Many people have arthritis in their feet and don’t even know it because there are no symptoms. When symptomatic, it elicits:

  • Pain and stiffness
  • difficulty walking
  • joint tenderness
  • Misshapen feet
  • Numbness and tingling


Treatment options

Adequate arthritis treatment is targeted at alleviating pain and preventing joint deformity. Some of the non-intervasive options include:

  • anti-inflammatory medications
  • weight loss, healthy diet, and suitable exercise
  • stem cell therapy


Stem cell therapy

With recent advancements in research, stem cell therapy is becoming an effective treatment for ankle arthritis. It is a non-surgical method that involves a single in-office injection. Stem cell therapy, in addition to platelet-rich plasma can help alleviate ankle arthritis pain. These are alternatives to surgery, which provide faster healing and improved functionality.

Stem cells are pluripotent cells in our body that have the power to differentiate into various type of cells

How it works

Stem cells are pluripotent cells in our body that have the ability to differentiate into various type of cells. Their stores in body decrease as we age, which is one of the reasons an adult will take longer to heal damaged tissues naturally. Stem cell therapy involves harvesting stem cells from the patient’s blood and fat tissue, creating a concentrated dosage, and injecting it directly into the damaged area of the ankle/foot. It is a single day procedure and patients are usually able to return to their normal activity within a short period of time.



A major study done at Mayo and published in the American Journal of Sports Medicine showed that patients suffering from knee arthritis showed significant improvement with stem cell therapy.


Most of outcomes data about stem cells for arthritis has come from outside the USA so far, from Iran and Thailand. These studies show that injection of stem cells into an arthritic knee may induce new cartilage formation, as verified with surgical arthroscopy (with a camera).


The results from stem cell therapy for arthritis have been shown to last from 6 months to at 2 years. There is some evidence of positive structural reversal of the arthritis-induced joint damage.


Overall, bone marrow-derived and fat-derived stem cells can be used to treat cartilage defects and arthritis in the ankle joint as elsewhere. This is a safe procedure with very low rates of known complications based on available data. Patients report consistent reduction of pain and considerable restoration of function. In that sense, it is superior to other orthopedic conditions such as hyaluronic injections and in some cases, even surgery.

Stem Cell Therapy for Alzheimers

Stem Cell Therapy for Alzheimer’s Disease


Alzheimer’s disease (AD) is characterized by progressive loss of cognitive functioning. There are currently 36 million people afflicted by this condition worldwide, and that number is expected to triple by the year 2050. Treatment of AD poses many challenges, as it is degenerative and not curable. Stem cell therapy has shown some promise in treating AD, and many recent studies support the use of stem cells as a viable option for Alzheimer’s disease.

Stem Cells for Alzheimers

Stem cells have been used successfully to counteract the symptoms of AD. Multipotent stem cells can differentiate into many cell types, such as oligodendrocytes, astrocytes, and neurons. These cells are derived from umbilical cord tissue and blood, amniotic fluid, bone marrow, and adipose (fat) tissue. With cell technology, stem cells can generate differentiate into types of glial and neuronal cells that are needed in AD treatment.


How Stem Cells Work


In mouse subjects with AD, studies show that transplanted stem cells change into mature cell types that improve memory and learning. One clinical study showed improvements of cholinergic neuron numbers, as well as memory in such AD rats after being transplanted with stem cells. It is thought that differentiation, maturation, and integration of the stem cells lead to secreted factors that signal molecules to stimulate cholinergic neurogenesis, and possible, prevent further loss. It has been shown that stem cell grafts increase brain-derived neurotrophic factor levels, and also, lead to behavioral rescue in mouse models of AD.


Grafted stem cells also are thought to work by altering the microenvironment in animal subjects’ brains. This process may have a negative impact on the therapeutic effect of stem cell transplantation. Nerve growth factors could promote survival of the cells, and stem cells transduced with human nerve growth factor genes can integrate into the cerebral cortex of AD rats to enhance cognitive performance. Transplantation of stem cells is used to deliver potent therapeutic agents, as well. These include insulin-degrading enzyme, neprilysin, plasmin, and cathepsin B.


Stem Cell therapy for AlzheimersNeural stem cells express high levels of neurotrophins, such as NGF and BDNF. Stem cells deliver neurotropins to the diseased brain, possibly modulating endogenous synaptic plasticity and enhancing survival of neurons. Many clinical studies support this notion, and stem cell transplantation has also been seen to increase hippocampal synaptic density and improve learning and memory in many transgenic models. The enhancement of synaptic growth was found to reduce neuronal loss and elevate levels of glial-derived neurotrophic factor within the brain.


Chronic inflammation is thought to play an important role in AD. Certain stem cell populations can exhibit robust anti-inflammatory properties. Stem cells have been found to induce expression of certain anti-inflammatory factors, such as prostaglandin E2 and interleukin-10. Peripheral administration of human umbilical cord blood stem cells was shown to reduce AD pathology by a mechanism that involves modulation of CD40 signaling. There is growing evidence that stem cells will also modulate the immune system. Because AD is an inflammation-associate condition, stem cells may reduce migrogliosis and expression of proinflammatory cytokine tumor necrosis factor. A few clinical studies suggest that mesenchymal stem cells can positively influence inflammation in AD models.


Clinical Studies


In a research study, embryonic stem cells were evaluated, a murine brain injury received a transplantation. The cells were capable of maturing into cholinergic and GABAergic neuronal subtypes and synaptically integrated with host neuronal circuits. This lead to improvements in impaired spatial memory and learning. Stem cells were also found to work in a rodent model study to decrease neuroinflammation, reverse cognitive deficits, and attenuate certain neuropathology. Intravenously, stem cells are capable of crossing the blood-brain barrier, and they can migrate to regions of neural injury. This has been done successfully in several studies.


Researchers recently used umbilical cord blood stem cells in an open-label phase I clinical trial. Nine patients with AD were given treatment. At three months, no patient had any serious adverse event from surgical transplantation of stem cells. Umbilical cord stem cells were also used to express high levels of angiogenic growth factors, which shown migratory activity. Overall, stem cell therapy for AD has enormous promise but more research is needed. MSC-based therapies have been best for human clinical trials.


Bone marrow stem cells have been found in one study to increase in number of positive cells for choline acetyltransferase. In addition, these cells removed AB plaques from the hippocampus and reduced substance deposits in AD mouse models. Human stem cells were found to enhance autophagy, promote AB clearance, and increase neuronal survival in another study. Intravenously injected stem cells were found in the brain for up to 12 days following the injection in animal models, and one report suggested that adipose-derived MSCs improve ACH levels, cognitive function, and locomotor ability in aged mice. The beneficial effects of stem cells were also associated with activation of M2-like microglia.


R3 Stem Cell offers regenerative therapy for Alzheimer’s disease at several of its 34 Centers nationwide. Call (844) GET-STEM today for a complimentary consultation to see if you are a candidate!



Chen WW & Blurton-Jones M (2012). Concise Review: Can Stem Cells be used to Treat or Model Alzheimer Disease? Stem Cells, 30(12), 2612-2618.

Chen J., Tang Y.X., Liu Y.M., Hu X.Q., Liu N., Wang S.X., Zhang Y., Zeng W.G., Ni H.J., Zhao B., et al. Transplantation of adipose-derived stem cells is associated with neural differentiation and functional improvement in a rat model of intracerebral hemorrhage. CNS Neurosci. Ther. 2012;18:847–854. doi: 10.1111/j.1755-5949.2012.00382.x.

Darlington D., Deng J., Giunta B., Hou H., Sanberg C.D., Kuzmin-Nichols N., Zhou H.D., Mori T., Ehrhart J., Sanberg P.R., Tan J. Multiple low-dose infusions of human umbilical cord blood cells improve cognitive impairments and reduce amyloid-β-associated neuropathology in Alzheimer mice. Stem Cells Dev. 2013;22:412–421. doi: 10.1089/scd.2012.0345.

Duncan T & Valenzuela M (2017). Alzheimer’s disease, dementia, and stem cell therapy. Stem Cell Res Ther, 8, 111.

Ha S., Ahn S., Kim S., Joo Y., Chong Y.H., Suh Y.H., Chang K.A. In vivo imaging of human adipose-derived stem cells in Alzheimer’s disease animal model. J. Biomed. Opt 2014;19:051206.

Honmou O., Houkin K., Matsunaga T., Niitsu Y., Ishiai S., Onodera R., Waxman S.G., Kocsis J.D. Intravenous administration of auto serum-expanded autologous mesenchymal stem cells in stroke. Brain. 2011;134:1790–1807.

Lee J.K., Jin H.K., Bae J.S. Bone marrow-derived mesenchymal stem cells reduce brain amyloid-β deposition and accelerate the activation of microglia in an acutely induced Alzheimer’s disease mouse model. Neurosci. Lett. 2009;450:136–141. doi: 10.1016/j.neulet.2008.11.059.

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Read This Before Considering Bone Marrow Stem Cell Therapy

There are ISSUES with Bone Marrow Stem Cell Procedures

It’s important before undergoing a bone marrow stem cell therapy procedure that you truly understand a few facts. First of all, it should be obvious that the procedure involves you being the donor of the bone marrow. The provider will harvest the bone marrow from your pelvis. While the risk of infection is small and there is no risk of rejection, those are not advantages compared with other types of stem cell treatment. For instance, amniotic and umbilical cord tissue don’t cause rejection either, and the risk of infection is minimal.

Bone Marrow Procedures OFTEN Cause Chronic Pain


The first consideration with this is that the needle used for the harvest is fairly large and it is going through an extremely sensitive area. The covering of your pelvis has a ton of nerve endings and may hurt significantly with the procedure. In fact, several studies have shown up to a 40% incidence of chronic pain after a bone marrow harvesting. Can you imagine having successful knee pain relief only to trade it for pain in your hip area chronically?


The Amount of Stem Cells in Your Bone Marrow is a PROBLEM


The biggest concern with using bone marrow for stem cell procedure is simply a matter of numbers. Once a person reaches the age of 50, the amount of stem cells in one’s bone marrow literally drops off a cliff. There is an exponential drop in the number of stem cells and other regenerative cells that are available. At the age of 50, there is a 90% drop in stem cells in one’s bone marrow, and by the age of 70 that drops by 97%!


Bone marrow stem cell procedure’s can work very well for those in their 20s and 30s. This would include athletes and those in categories such as post traumatic extremity arthritis. But for those who have degenerative arthritis and are over the age of 50, it is a TERRIBLE idea to consider bone marrow stem cell therapy.

Bone Marrow Stem Cells Get Lazy



Another interesting fact that has come from research out of Case Western Reserve University in Cleveland, is that stem cells from the bone marrow do not work as well with increasing age. So in addition to their being a quantity problem, there is also a quality issue as well. The stem cells that we make get lazy, and there are also not enough of them as we age.


The argument that you should have a bone marrow procedure because it is your own tissue is also not valid. Donated tissue from the amniotic fluid, placenta or umbilical cord does not get rejected in the human body. The reason is that during processing, any DNA factors are removed. This leaves the tissue immunologically privileged. In over 10,000 cases to date, our Centers of Excellence have never had a rejection, disease transmission, or a deep infection.


The stem cell and regenerative counts in the tissue are exponentially higher than what is seen with bone marrow or adipose. I will cover adipose in a separate article.
With over 30 R3 Stem Cell Centers of Excellence nationwide, R3 is the nation’s leader in regenerative procedures. Not only does this include arthritis and soft tissue conditions, but also neurodegenerative, auto immune, COPD, kidney failure and much more.


Simply call us today at (844) GET-STEM so we can set you up with a free consultation at a center close to you.

Read This Before Undergoing Adipose Stem Cell Therapy

Adipose Stem Cell Therapy Has a Critical Flaw

We get asked frequently how good adipose stem cell therapy works. Rather than offering a short answer, I’d like to elaborate on adipose (fat) as a regenerative tissue.
While in the body, adipose tissue has a ton of regenerative cells in it. These cells require considerable amounts of oxygen, which they receive as our fat has an excellent blood supply in the body.

Most Adipose Stem Cells Die After the Procedure


This is a critical difference between regenerative cells that come from the products of conception such as the placenta or the umbilical cord. Those tissues do not require a considerable amount of oxygen. When adipose tissue is acquired during a mini-liposuction and processed in the room for a stem cell procedure, a problem occurs. Once those stem cells are placed into the area being treated such as the knee or the hip joint, they receive very little oxygen in their new home. Research has shown that over 85% of those cells subsequently die within just a couple of days.


So people think they are getting these super high cell counts, when in reality most of those cells will never be able to live to do any of the necessary repair work. This is why adipose stem cell therapy has been losing popularity in the US for years!


What About Stromal Vascular Fraction (SVF)?


One of the modifications that centers sometimes offer for adipose stem cell therapy is to add some enzymes to the fat such as collagenase. This is the procedure called stromal vascular fraction. While this additional step does offer benefits, the FDA has come down hard on this procedure. In fact, they recently filed an injunction against over 100 Centers performing this adipose procedure modification. So it is actually not allowed by the FDA in the United States.


Even if the procedure were allowed in the US, no data has shown that adipose stem cell procedures (even as SVF) work better than umbilical or amniotic regenerative procedures. Plus there are potential risks from the liposuction procedure itself.

As a result, what we are seeing is that adipose stem cell therapy is rapidly falling out of favor in the United States. Over 99% of the individuals calling into our centers and being seen want to discuss either amniotic or umbilical cord tissue stem cell procedures. These procedures utilize donor tissue that does not cause a rejection in the body, is safe and is strictly regulated by the FDA.


R3 Stem Cell has over 30 centers nationwide that have performed over 10,000 successful procedures. And we have not seen any rejection, deep infection, allergic reaction or disease transmission. There are MILLIONS of live regenerative cells in the amniotic and umbilical cord tissue. Download our Consumer Guide HERE.


Call today (844) GET-STEM to sign up for a free consultation to see if you or a loved one is a candidate for stem cell therapy!

Stem cell treatment for Amyotrophic Lateral Sclerosis

What is ALS?

This disease is named after New York Yankee first baseman Lou Gehrig who developed it in 1939. More formally known as Amyotrophic Lateral Sclerosis (ALS), is a neurodegenerative disease of an unknown cause that is characterized by degeneration of motor neurons in the brain and spinal cord. It often moves very quickly from weakness in limbs to progressive paralysis and eventually, respiratory failure. It typically occurs in the forties through seventies. is caused by a combination of genetic and environmental factors. It has been very difficult to find effective treatments for ALS.

Numerous trials are underway that testing new approaches that use stem cells for ALS treatment

What are Stem cells?

Stem cells are the body’s own cells from which all other cells with specialized functions are generated. These daughter cells either become new stem cells or differentiate into specialized cells (blood cells, brain cells, heart muscle, etc.) There are several sources of stem cells:

  • Embryonic stem cells: come from 3 – 5 days old embryos. These are pluripotent stem cells and can divide into more stem cells or can become any type of cell in the body, and can be used to regenerate or repair diseased tissue and organs.
  • Adult stem cells: found in most adult tissues, such as bone marrow or fat. They have a more limited ability to differentiate into various cells of the body. Lately, it has been found that adult stem cells may be able to create unrelated types of cells, such as bone marrow stem cells forming heart muscle cells.
  • Perinatal stem cells: are found in amniotic fluid and umbilical cord blood.


Stem cell treatment for ALS

There has been a lot of research on using stem cells for the treatments for ALS. Induced pluripotent stem cells (iPSCs) have been used as a source of motor neurons from individual ALS patients to study why and how motor neurons degenerate in ALS. Both upper and lower motor neurons, as well as astrocytes, can be made from iPSCs.

Motor neurons derived from iPSCs can be tracked over time to understand if a test compound has a positive or negative effect. Furthermore, comparing the motor neurons derived from iPSCs can help understand patients’ clinical picture.

More importantly, stem cells can also help in treating the disease. They can be used to produce cells that motor neurons in the brain and spinal cord.


Several trials are underway that testing new approaches that use stem cells for ALS treatment. One of these includes using mesenchymal stem cells can be taken from the patient’s own bone marrow or fat tissue and then modified to enhance their support for dying motor neurons. Another trial is focused on studying the effects of injecting muscle tissue into the fluid surrounding the brain and spinal cord. A recent study in JAMA Neurology reported that the treatment was safe and well-tolerated, resulting in a decreased rate of disease progression during six months after the injections, as compared to six months before treatment.

There is still a lack of high-quality evidence to guide the clinical use of stem cell therapies for the treatment of ALS in the clinic, but the results of recent and current trials have been very encouraging.

The Real Problem with Bone Marrow Stem Cell Therapy

There’s a lot written online these days about stem cell therapy using one’s own bone marrow. Some providers will say “you should only have your own bone marrow used, bone marrow is better for regenerative medicine,” etc. This is concerning as it’s mostly NOT a good idea.

When you really look at using one’s own bone marrow, there are TWO GLARING PROBLEMS that should be taken into consideration. The first issue simply comes

Young athletes are great bone marrow stem cell candidates

down to pure math. When a person is in his or her 20s or 30s, the amount of regenerative cells available is plentiful. For instance, when an athlete is considering undergoing a regenerative procedure, bone marrow may be an excellent option. For an individual in his or her 30’s with a post traumatic cartilage defect, it also makes sense to consider bone marrow procedures.

However, once a person reaches the age of 50, undergoing a bone marrow procedure is mathematically NOT a good idea. Studies have shown that the amount of stem cells available in one’s bone marrow drops exponentially as we age.

Specifically, by the age of 50, that amount drops by about 90%. By the age of 70, it drops by over 95%. In addition, researchers at Case Western have shown the stem cells that are still present do not function as well as those when a person is younger. Basically, stem cells in older individuals get LAZY.

Studies in the past have also shown a significant problem with what is obtained even under the best of circumstances with a bone marrow aspiration. With current techniques, the needle is placed into the iliac crest of the pelvis. Approximately 60 mL of bone marrow is aspirated for use.

What exactly is in that bone marrow?

That question has been answered by studies looking at the composition. The first 2 mL contains a decent amount of stem cells. Unfortunately, the rest of the 60 mL mostly consists of blood. This has very few stem cells and not very many regenerative cells either.

So in addition to age becoming a mathematical liability for the amount of cells we have available, the current techniques for aspiration hurt the situation even more.
The combination of the mathematical decay of the amount of stem cells we have available with aging, the decrease in function of what stem cells remain, and the current technical deficiencies with aspiration all add up to a sub-optimal regenerative procedure using one’s own bone marrow.

Complications with the Aspiration

And if that wasn’t enough to discourage people from undergoing a bone marrow procedure, consider the potential complications of the iliac crest aspiration. On average, studies show a 35% incidence of chronic pain from the aspiration. This means a person may have pain that last well over six months afterwards.

In addition, there have been reports of pelvic fractures, vascular injury, nerve injury and even a bowel perforation can occur. Imagine going in for a simple bone marrow stem cell procedure and ending up needing a blood transfusion and a bowel repair!

For the younger population, bone marrow should still be in the conversation. However, we simply have much better options available today for regenerative procedures. Umbilical cord and amniotic stem cell treatments have been shown in many peer reviewed studies to be safe and very effective for many conditions.

In over 10,000 cases performed over five years, R3’s Centers of Excellence have not experienced any disease transmission, deep infection, no rejection, and of course no chronic pain as no aspiration is necessary.

With umbilical cord tissue and amniotic fluid being obtained ethically and in accordance with FDA regulations, why risk any of the complications and poor cell numbers associated with a bone marrow procedure?

R3 Stem Cell offers effective regenerative procedures at over 30 Centers of Excellence nationwide. We also have a Concierge center in Las Vegas, where patients from around the country and internationally come for first-rate treatments.

Initial consultations, whether in person or over the phone, are offered complimentary along with an imaging review. Call us today at (844) GET-STEM and we will locate a provider close to you!

Does Stem Cell Therapy Work with Bone on Bone Arthritis?

One of the main questions we receive from individuals considering regenerative therapy for an arthritic joint is “Will the stem cell therapy work if I have bone on bone arthritis?” Interstingly, the answer is yes!

We didn’t always think it would help. When R3 first started over five years ago, we told providers it probably wouldn’t work. Thankfully, we were wrong! The outcomes proved to be exceptional over 80% of the time.

As the past five years have gone by and patient after patient has gotten dramatically better from the treatment, we have learned what is most likely happening with the joint treatment.

How Arthritis Occurs


Throughout life, people make cartilage at the same rate. It doesn’t matter whether a person is twenty or eighty, cartilage formation occurs consistently. The issue concerns the rate of cartilage loss. Unfortunately, with age comes an increased rate of cartilage loss. So the ratio of formation to loss turns into a mismatch.

This leads to an overall loss and degenerative arthritis. What’s being accomplished with a regenerative procedure (e.g. umbilical cord stem cell therapy), is putting the ratio back into the patient’s favor. It is NOT a cure or a complete fix, anyone who says that is not being realistic.

With the ratio being put back into the patient’s favor, cartilage formation can accumulate in a joint. Often times, noticeable joint improvement will occur on x-rays over time. It does not need to be a ton, simply a couple millimeters will usually be enough to create tremendous relief for patients.

How long will the relief last from a regenerative injection?


This is variable, and there is no set time frame. We have seen patients treated five years ago doing fantastic, while others may need a repeat treatment after a couple years. A person may not need another stem cell treatment, but may just benefit from a PRP treatment. The relief usually starts within the first month, and continues to improve for over six months.

There is no age limit to the treatment. R3’s Centers have seen patients upwards of age 102. The desire may simply be to walk farther, play more with the grandkids or play golf more often. Thankfully, the treatments are extremely safe in addition to being effective over 80% of the time.

How is Amniotic and Umbilical Cord Tissue Regulated?


Amniotic and umbilical cord tissue is strictly FDA regulated. During processing, any DNA factors are removed so it does not lead to rejection. The best labs, such as the ones R3 works with, ensure very high cell viability by not using radiation and only minimal preservative. This is one reason the outcomes at our Centers has been so amazing.

With the outcomes being so exceptional, over 95% of patients considering treatment at R3 now ask for amniotic and umbilical cord tissue treatment. Along with the outcomes, there is no need for harvesting so the potential for chronic donor site pain is avoided. When a bone marrow or adipose procedure is undergone, the potential for chronic donor site pain is over 30%, and with each year that goes by the regenerative cell counts in the human body decreases considerably.


R3 Stem Cell has over thirty Centers of Excellence nationwide. All of them offer a free consultation, and the providers are first rate. Call today to set up your visit to R3, where Regenerative Medicine is Made Easy!

Do you have back pain that radiates to your ribs? This might be the cause.

If you’ve been scouting the internet desperately trying to find a cause for your back pain then you are not alone. In fact, it’s estimated that 80% of Americans suffer from back pain at some point in their life and that at any one time around 10% of the US residents have chronic back pain issues. Chronic pain can take a serious toll on everything from your ability to do the gardening to fulfilling your role at work. Inevitably this means that a significant proportion of sufferers develop depression and feel hopeless about their condition. Most of these individuals will suffer with what we call chronic lower back pain ie back pain in the portion of the spine that is below your rib cage. But what if this doesn’t describe your pain at all? What if your pain is in the middle of the back and often radiated across the ribs? Well, you won’t find much about this sort of back pain online and it can be frustrating trying to find a diagnosis. If you are at all in doubt, speak to a specialist spine centre who see hundreds if not thousands of these sorts of patients each and every year as they are bound to be able to quickly identify a cause due to expertise a family practitioner just doesn’t have.

any cause of back pain it is imperative you seek specialist advice from a spinal centre

What could cause mid back pain?


There a number of causes of middle back pain including:


  • Degenerative disc disease. Whilst this is significantly less common than having slipped or degenerative discs in the lumbar or cervical spine it can occur either symptomatically or asymptomatically.
  • Compression fracture of the thoracic spine. As we grow older we lose bone mass and grow more likely to suffer from osteoporosis. Osteoporosis is a severe form of bone mass loss that can cause wedge or compression fractures of the bones in the spine (where the bones literally buckle under the weight of the head and neck).
  • Problems affecting any of the following organs may cause referred pain (this is why it is important not to self diagnose – a trained doctor will be able to rule out serious disease in these organs):
    • Oesophagus
    • Stomach
    • Liver
    • Gallbladder
    • Pancreas


Degenerative disc disease is probably most likely in those with back radiating to the ribs as the bulging disc can cause radiculopathy (this is when the bulging disc compresses a nerve, resulting in pain in the area that nerve supplies eg the rib cage).


What can I do to treat this condition?


As with any cause of back pain it is imperative you seek specialist advice from a spinal centre with trained spinal doctors. If the pain is caused by degenerative disc disease then treatment will begin conservatively and work up to more serious interventions. This can start with physical therapy, include drugs like non steroidal anti inflammatory or involve surgery in severe cases.

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