Bone Marrow Derived
Stem Cell Injections

Bone Marrow Derived Stem Cell Injections at R3 Stem Cell Clinics

Nonoperative pain management for joint arthritis, such as in the hip, knee and shoulder, has to date consisted mostly of pain suppressing medicines. This often includes cortisone injections, topical analgesic creams and anti-inflammatory medications by mouth. What these conditions really need is a game changer, a treatment that alters the condition’s underlying arthritis.

Stem Cells are like a “blank slate” and can differentiate into all types of cells for regeneration.

Regenerative medicine offers the potential for a real cure with stem cells, growth factors and platelets to heal damage.

One of the main medical procedures that continues to increase in popularity is bone marrow derived stem cell injections. This bone marrow contains a significant amount of the biologic materials necessary for regeneration, with the added benefit that the material comes from the patient’s own body.

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Here are answers to many of the frequently asked questions we receive.

WHAT ARE BONE MARROW DERIVED STEM CELL INJECTIONS?

One of the reasons why stem cells are used as therapy for conditions that manifest through joint pains is the fact that they have regenerative properties, meaning the potential to repair and reverse damaged joints.

Bone marrow is a spongy tissue inside a person’s bones, and produces cells that are vital to existence including platelets, white blood cells and red blood cells. All of these cells begin in the marrow as stem cells, which are essentially a “blank slate” type of cell. With a “blank slate”, the stem cell can differentiate into virtually any type of cell necessary in the body such as cartilage, tendon or muscle. There are three types of adult stem cells in the human body. One type eventually turns into blood components, with a second destined to become lining of the endometrium.

The third, and most important for musculoskeletal regenerative medicine, are mesenchymal stem cells found in bone marrow. They have been used in animal models to regenerate cartilage and in human models to regenerate bone. (Centeno et al, 2008)

The richest sources of stem cells in the body for concentrated amounts of bone marrow are in the iliac crest of the hip and the bones of the spine. For the easiest acquisition process, the iliac crest is used for the procedures in an outpatient procedure.

Harvesting bone marrow from the iliac crest hip bone.

Stem Cells for Autoimmune Diseases

Clinical studies and case reports are showing much support for the use of stem cell therapy to treat autoimmune diseases. In mice subjects, one study showed efficacy of stem cells on experimental autoimmune hearing loss. Mice treated once a week for 6 weeks had improved anti-inflammatory cytokine induction and reduced inflammation. Some mice were found to have moderate improvements after treatment.

Regarding multiple sclerosis, researchers have proven that the progression of disease can be slowed or stopped, and some patients have shown improvement in motor function and quality of life. In 10 patients with polymyositis, stem cells were transplanted. Researchers found improvements with functional abilities after several treatments. Perhaps the best efficacy was noted in patients with rheumatoid arthritis. Researchers documented ability to stand without help or medications following stem cell therapy options. The study participants were previously unable to ambulate and chair-bound.

A large controlled study involved MS patients treated with stem cells. The patients received three injections of stem cells into the spinal fluid at 3-month intervals. Reports found a 70% improvement rate of 10 patients so far, and many reported reductions in level of disability. Overall, the ongoing study is showing promise for the use of stem cells to treat, alleviate symptoms of, and possibly cure MS.

HOW ARE THESE INJECTIONS PERFORMED?

First of all, the doctor will extract bone marrow from the patient’s hip bone at the iliac crest. The area is prepped sterile and numbed considerably to make it tolerable. Since the patient continuously makes new bone marrow, it does not present any lasting problem to harvest some of the bone marrow.

Approximately 30 to 60 cc’s of bone marrow is acquired, and it is processed immediately to concentrate down the stem cells and growth factors. In the past, obtaining regenerative cells from a patient’s bone marrow was very difficult and expensive. Now, thanks to new technologies and medical advancement, it actually takes the doctor very little time and it is a fairly simple outpatient procedure to obtain the bone marrow.

Once the marrow is harvested, it is then placed in a centrifuge and spun until a concentrated substance is obtained consisting of the most important regenerative components. Afterwards, the patient is injected with the substance in the same day, without the need for hospitalization.

IS THIS PROCEDURE PAINFUL?

Harvesting bone marrow from the iliac crest does entail some moderate pain. While plenty of numbing medicine is used during the procedure, there will be some mild to moderate discomfort. This may persist for a few days to weeks and slowly subside as the area heals up.

The injection of the prepared bone marrow into the affected joint is no more painful than a typical cortisone injection. For a few days afterwards, the joint may have slight increased pain due to the inflammatory reaction generated. This reaction is normal, as inflammation is the first stage of healing.

WHO DO BONE MARROW DERIVED INJECTIONS HELP?

As with other types of regenerative medicine, bone marrow derived stem cell injections work better for some cases than for others. There have not been large scale studies to date looking at bone marrow derived stem cell injections in humans. In a 2011 study out of the Beijing Institute of Technology, bone marrow mesenchymal stem cells were shown to have an excellent potential for cartilage production in animals (Li et al, 2011). A recent study in canines showed that bone marrow mesenchymal stem cells were effective in repairing bone defects(Kang et al, 2013).

An old knee injury can lead to post-traumatic arthritis.

With the positive results seen in animals, the treatments have been introduced for humans. R3 Stem Cell Clinics has research beginning looking at the effect of bone marrow derived stem cell injections for the following applications:

Spinal Arthritis in facet joints (neck and back)
Extremity arthritis including knee arthritis, hip arthritis, ankle and shoulder arthritis
Sacroiliac Joint Arthritis

HOW ARE THESE INJECTIONS DIFFERENT FROM CORTISONE SHOTS?

Bone marrow derived stem cell injections have as goal to treat the damaged tissue, so that the body can heal. Not only to heal the problem, but to provide pain relief at the same time. Cortisone shots, on the other hand, do not have any other role than pain relief by providing anti-inflammation. While cortisone (steroid) injections are effective, they are not long term.

ARE THERE RISKS WITH THE PROCEDURE?

With the procedure being outpatient and minimally invasive, the risks are low. But they do exist and include potential for infection, allergic reaction, bleeding, pain at the harvest site, wound drainage and failure to relieve a person’s pain. Risks should be discussed with your treating doctor.

WHAT ARE MY OPTIONS

R3 Stem Cell Clinics offer various research projects and treatment opportunities with bone marrow derived stem cell injections for both extremity and spinal joint pain and arthritis.

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SUCCESS STORIES

*Outcomes will vary between individuals. No claims are being made with regenerative therapies. The FDA considers stem cell therapy experimental. See our THERAPY COMMITMENT HERE.

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ABOUT US

The information provided by R3 Stem Cell is not a substitute for professional medical advice, diagnosis, or treatment. Individual results may vary and only your medical professional can explain all the risks and potential benefits of any therapy based on your circumstances. R3 Stem Cell does not recommend or endorse any specific tests, products, procedures, opinions, or other information that may be mentioned on this website. Reliance on any information provided by R3 Stem Cell, its employees, others appearing on this website at the invitation of R3 Stem Cell, or other visitors to the website is solely at your own risk. R3 Stem Cell is not responsible for the outcome of your procedure. The FDA considers stem cell therapy experimental at this point.