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Free Download: Stem Cell Therapy for Diabetes
Disclaimer:
The information provided by R3 Stem Cell is for educational purposes and is not a substitute for professional medical advice, diagnosis, or treatment. Individual results may vary and are not guaranteed. The FDA considers stem cell therapy experimental at this point.
Any claims made on this website refer to procedures performed OUTSIDE of the USA. R3 Stem Cell has clinics in Mexico, Philippines, South Africa, Turkey, India, Pakistan.
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Every day, R3 Stem Cell receives inquiries worldwide from individuals asking if stem cell therapy can help with diabetes. Spoiler alert: It can help a lot! In this guide, we’ll go through the basics of how stem cells work for diabetes, the latest research, and what to expect with a regenerative procedure.
Conventional therapies for diabetes, such as insulin, are not able to effectively prevent long-term complications that often include vascular degeneration, blindness, and kidney failure. The search for alternative approaches such as with stem cells is therefore of paramount clinical interest.
Stem cell therapy for diabetes is turning out to be an excellent opportunity for individuals to control blood sugars, reduce Hb-A1C and prevent the secondary complications that are simply NOT possible with traditional therapies. Let’s dig in!
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Diabetes is a very common disease that affects over 450 million people around the world. Diabetes occurs as two types. Type 1 is an autoimmune condition where one’s immune system attacks and destroys your insulin-producing cells in the pancreas. Type 2, which is much more common, is an acquired variety often due to correctible lifestyle issues (overweight, high blood pressure or cholesterol).
The International Diabetes Federation (IDF) introduces diabetes as one of the fastest-growing global health emergencies of this century and estimates that in 2019, 463 million people worldwide had diabetes. This number is expected to increase to 578 million by 2030 and 700 million by 2045.
Due to one’s blood glucose levels being chronically abnormal, secondary complications may occur such as neuropathy, kidney failure, skin ulcers, cardiovascular disease and more.
Diabetes type 1 and type 2 come from different causes: In diabetes type 1, the pancreas does not make insulin, because the body’s immune system attacks the islet cells in the pancreas that make insulin.
In diabetes type 2, the pancreas makes less insulin than used to, and your body becomes resistant to insulin. This means your body has insulin, but stops being able to use it.
We don’t know why the immune system attacks the pancreatic islet cells.
Possible factors that might trigger this autoimmune reaction include:
And sometimes, people can lose the ability to make insulin altogether because of:
While both types of diabetes have inherited or genetic aspects, the insulin resistance that causes type 2 is related to having too much body fat.
Unlike type 1, type 2 diabetes:
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Damage to any part of the process that moves glucose from your blood to your cells results in diabetes.
Signs of both type 1 and type 2 diabetes include:
People with type 2 diabetes may also experience:
At present, neither oral hypoglycemic drugs nor insulin is a cure for diabetes; these treatments increase the risk of complications, such as hypoglycemia, gastrointestinal intolerance, heart failure, and atypical fractures.
DM is the ninth most common cause of death globally, and most diabetic patients have at least one complication. A large observational study showed that 50% of patients with type 2 diabetes had microvascular complications, and 27% were associated with macrovascular complications. The development of common DM complications, including diabetic kidney injury, diabetic encephalopathy, and diabetic chronic ulcers, determines the quality of life of patients.
Depending on what type of diabetes you have, blood sugar monitoring, insulin and oral drugs may be part of your treatment. Eating a healthy diet, staying at a healthy weight and getting regular physical activity also are important parts of managing diabetes.
Treatment for type 1 diabetes
involves insulin injections or the use of an insulin pump, frequent blood sugar checks, and carbohydrate counting. For some people with type 1 diabetes, pancreas transplant or islet cell transplant may be an option.
Treatment of type 2 diabetes
mostly involves lifestyle changes, and monitoring of your blood sugar, along with oral diabetes drugs, insulin or both.
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Stem cell therapy for diabetes represents a new paradigm, where the treatment can actually facilitate repair and regeneration of the pancreas while preventing some of the secondary complications. While not a cure for diabetes, it can truly provide patients with better blood sugar control along with improvements in kidney and heart function, neuropathy pain relief and better skin healing.
A 2016 review of 22 studies on stem cell therapy for diabetes showed that infusion of umbilical cord stem cells for Type 1 diabetes worked exceptionally better than traditional treatment alone. The authors noted that the stem cell treatments were very safe and that earlier treatments produced better results.
A study performed that same year looked at umbilical cord stem cell infusions for over 50 patients with Type 2 diabetes. Postprandial glucose and HbA1c measurements were lower in the experimental group for up to 2 years. Insulin usage and fasting C-peptide were significantly improved in the stem cell treatment group. The conclusion was that transplant of umbilical cord MSCs is feasible and safe for Type 2 diabetes.
To determine the efficacy and safety of umbilical cord-derived mesenchymal stem cells (UC-MSCs) with type 2 diabetes mellitus (T2DM), a Chinese study evaluated 91 patients who were randomly assigned to receive an intravenous infusion of UC-MSCs (n = 45) or placebo (n = 46) three times with 4-week intervals and followed up for 48 weeks. At 48 weeks, 20% of the patients in the UC-MSCs group and only 4.55% in the placebo group achieved a 50% reduction in insulin needs and HbA1C <7%. No major UC-MSCs transplantation-related adverse events occurred.
Overall, 13.5% (5/37) patients became insulin-free at 8–24 weeks after UC-MSCs transplantation and remained insulin-free without re-use for 37.2 Å} 15.2 weeks. No patient in the placebo group became insulin-free. UC-MSCs treatment reduced daily insulin requirement, decreased HbA1c levels, and ameliorated insulin resistance in a time-dependent manner.
In a meta-analysis titled, “Clinical Efficacy of Stem Cell Therapy for Diabetes Mellitus “, 22 eligible clinical trials reporting stem cell-based therapy for DM with a total of 524 patients were evaluated. Both Type 1 and Type 2 DM were evaluated.
The authors concluded the following: (1) remission of DM is possible following stem cell therapy; (2) stem cell transplantation can be a safe and effective approach for therapy of DM; (3) available data from these clinical trials indicate that the most promising therapeutic outcome was shown in mobilized marrow CD34+ HSCs; (4) patients with previously diagnosed diabetic ketoacidosis are not good candidates for the applied approaches stem cell therapy; (5) stem cell therapy at early stages after DM diagnosis is more effective than intervention at later stages.
Another meta-analysis titled, “Efficacy of mesenchymal stem cell transplantation therapy for type 1 and type 2 diabetes mellitus” of ten studies with 239 patients showed that compared with baseline levels, significant changes were found in the HbA1c, FBG, PBG, F-CP, and insulin requirements of patients with DM after they received MSC therapy. It was clear that MSCs had a therapeutic effect on blood glucose regulation in patients with DM, and the benefits for patients with T1DM were more pronounced.
Mesenchymal stem cell derived exosomes have a repair function similar to MSCs, but do not have the shortcomings of MSCs in terms of difficulties associated with storage. MSC-Exos are rich in a variety of growth cytokines, repair proteins, and therapeutic noncoding RNAs, which can promote the repair of organs damaged by DM and its complications by regulating inflammation, vascularization, and antiapoptotic mechanisms. The use of MSC-Exos may be an effective treatment strategy for DM and its complications.
Exosomes have been shown to have a significant mitigatory effect on Type 1 Diabetes by increasing the expression of anti-inflammatory factors (e.g., IL10), and the population of Tregs that are equipped to suppress the immune response, preventing immune overactivation and autoimmune damage (101). In addition, the results of the study by Shigemotokuroda et al. also confirmed that MSC-EVs could inhibit islet inflammation, significantly increasing the plasma insulin levels, and effectively delaying the occurrence of T1DM. These results suggested that MSC-EVs have great potential as a cellular therapy for the prevention of T1DM.
Stem cells and exosomes act in the body through several mechanisms. They do NOT become part of a patient’s DNA, which means they do not engraft into the person’s existing cells.
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They act through
Angiogenesis
provokes formation of new blood vessels.
Reduce inflammation
diabetes is associated with significant pancreatic inflammation along with the areas that deal with the secondary complications, and the regenerative biologics reduce it nicely.
Immune system modulation
the stem cells and exosomes modulate the immune system very differently than steroids. Instead of blanketly suppressing the immune system, the regenerative biologics tamp down the harmful processes while amping up the beneficial ones. This includes ramping up production of several helpful growth factors and cytokines, while tamping down harmful ones.
Cellular signaling
the biologics are able to perform “cell to cell” communication. This promotes recipient cells to proliferate their growth factor production, protein production and regenerate tissues that are damaged.
Prevent cell death
most cells have a timed death, where they are only allowed to live a certain length of time. This is called apoptosis. The regenerative biologics allow normally functioning cells (i.e. islet cells) to live longer, and spare them from the pre-programmed death.
Preventing scar tissue
Diabetes patients experience significant scarring throughout the pancreas. Once that scar tissue forms, it becomes nonfunctional. Stem Cells and exosomes are great at preventing scar tissue.
Stem Cells can also release a huge variety of molecules into the extracellular environment. These molecules, which include extracellular vesicles (exosomes), lipids, free nucleic acids, and soluble proteins, exert crucial roles in repairing damaged tissue. Along with offering stem cells for the treatment of diabetes, R3 Stem Cell includes stem cell exosomes, which are a type of extracellular vesicle participating in extensive cell to cell communication for brain tissue repair and regeneration.
R3 Stem Cell’s regenerative biologics originate from umbilical cord tissue that has been donated after a scheduled c-section. No baby (or mother) is harmed during the c-section procedure. The umbilical cord tissue is normally discarded, but if the mother passes the screening test then the umbilical cord is immediately sent to the lab.
The lab carefully processes the umbilical cord to generate large amounts of stem cells and exosomes that are of the highest quality possible. The lab team consists of multiple PhD’s working in ISO Certified, cGMP compliant clean rooms to ensure quality assurance that exceeds USA FDA standards. The proprietary production process combines the highest potency, safety and affordability for providers to confidently offer exosome procedures.
Millions of dollars have been invested into the pharmaceutical grade production of the biologics including first rate clean rooms, bioreactors, nano-particle tracking analyzers, cytometers, PCR, tangential flow machines and real time environmental monitoring. The quality assurance testing complies with screening and testing standards consistent with the American Association of Tissue Banks, cGMP standards, FDA regulations and the highest level of any regulatory agency globally.
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R3 Stem Cell’s Centers of Excellence globally include umbilical cord stem cell derived exosomes with umbilical cord stem cells to provide enhanced results. Exosomes are lipid bound extracellular vesicles (acellular) produced by cells which contain a plethora of growth factors, cytokines, mRNA and other proteins.
They are exceptionally helpful in cell to cell communication, and very effective for reducing inflammation when they become ingested by their recipient cell. They act as shuttles to send nucleic acids and proteins to other cells, in this way, allowing cell-to-cell communication and transporting molecules among both close and distant cells. In general, these released proteins are important regulators of intracellular information.
Exosomes could be the mediators of many stem cell-associated therapeutic activities. Considering they are 100 times smaller than stem cells, they do not have any issues passing through the blood-brain barrier to reach the brain from the bloodstream.
After a decade of performing over 24,000 stem cell procedures worldwide, R3 knows that regenerative procedures are safe. The quality control employed during stem cell production is second to none, and the side effects R3 sees are usually mild to moderate and temporary.
They may include itching, dizziness, lightheadedness, low-grade fever, chills, headache, and nausea. These are typically temporary. If a patient has an allergic reaction to the multivitamin or a preservative, all of R3’s Centers have the medications to resolve it quickly.
One of the questions we get asked a lot is, “Will the stem cells get rejected?” The answer is NO.
MSCs do not express major histocompatibility complex (MHC) antigens of the class II subtype and contain low levels of MHC molecules of the class I subtype. MSCs also lack the co-stimulatory molecules essential for immune detection, including CD40, CD80, and CD86.
Therefore, MSCs generally have low immunogenicity and can avoid immune rejection by the recipient, which serves as the foundation for their successful application without needing to match the donor to the recipient. Scientists call this being “immunologically privileged”.
Another question often asked is “Is there a chance of a tumor forming?” Once again the answer is NO. The mesenchymal stem cells and exosomes used during treatment have never been shown to have tumor-forming potentials. In fact, they have been shown to be anti-tumor forming.
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For the past decade, R3 has been successfully treating diabetes patients with IV stem cell and exosome therapy. The cells and exosomes are attracted to inflammation, which is a large component of diabetes effects either on the pancreas, kidneys, eyes, or other areas.
R3’s providers will calculate the amount of stem cells based on patient weight and diabetes severity. It will range from 1 to 4 million stem cells/kg. Depending on the total amount, treatment may need to be broken up into two sessions, three at the most for optimal safety.
R3 Stem Cell’s diabetes treatment protocols are based on the latest research along with Best Practice Protocols developed over the past decade to help patients achieve the best outcomes possible. Safety is paramount with the biologics products being rigorously tested prior to use, and expert providers managing each treatment as if it were a family member!
Although autologous (your own) stem cells provide significant advantages, allogeneic (donor) stem cells have more advantages. First of all, autologous MSCs need a long time to culture and expand, which limits its application in diabetes treatment, while allogeneic stem cells can be obtained and expanded from the freezer more quickly, thus avoiding the delay of time window.
Diabetes patients need a LOT of stem cells for the outcome to be satisfactory, which is just not obtainable from one’s own stem cell harvesting. Considering that the viability of donor stem cells after cryopreservation averages 87%, patients are able to achieve the amount of cells needed without the harvesting procedure.
Second, age is a factor that affects the physiological characteristics of MSCs. Studies have shown that stem cells from elderly donors have decreased proliferation and differentiation ability. This means they are less effective!
Similar to the research mentioned above, R3 Stem Cell’s outcomes for diabetic patients have been exceptional! The patient satisfaction rate is 85% year over year. Patients typically see increased energy, function, better glucose management, reduced Hb-A1C and less need for traditional medications.
It may take several months to see all of the improvements, although we have had patients symptomatically feel much better within the first couple of weeks. It should be noted, again, that stem cell therapy does not cure diabetes, and will need to be repeated every 12-24 months for additional benefits.
Because stem cell therapy for diabetes does benefit from repeat treatments, it’s important to make it affordable. Repeat therapies can help people achieve additional improvements. So a lot of patients seek additional treatments at R3 Stem Cell every twelve to twenty four months.
Unfortunately, stem cell clinics in Colombia, China and Panama charge over $20,000 USD for diabetes treatment. Because the one treatment cost so much, how are individuals supposed to budget for that every year?? R3 Stem Cell’s fees are less than half that for 100 million high-quality stem cells!
For the past decade, R3 Stem Cell’s Centers globally have performed over 24,000 regenerative procedures in six countries. Over a thousand have been for either diabetes or secondary complications of the disease. Patient satisfaction across all conditions treated is 85%!
R3 combines safety, effectiveness and affordability for the therapies. Internationally, the Intellicell is used, which is culturing the most active mesenchymal stem cells to create the “smartest” stem cell in the world!
Our experience with diabetes patients has been extensive, and our Success Stories on R3’s YouTube Channel are impressive. You can visit the channel Success Story Playlist HERE.
R3 Stem Cell offers free consultations for individuals to discuss whether regenerative therapy is indicated for their diabetes. Simply call +1 (844) GET-STEM or +1 (480) 808-7057 to schedule yours!
You’ve tried everything else. Now try stem cell therapy. Contact R3 Stem Cell: (844) GET-STEM.
Any claims made in this guide refer to procedures performed outside the USA.
References
David Greene, MD, PhD, MBA, Founder/CEO
R3 Stem Cell offers treatments that bring patients hope and options. Hope that surgery can be avoided, and tissue injury can be repaired with patients being able to get back to desired activities.
Founder and CEO David Greene, MD, PhD, MBA writes extensively on regenerative medicine and gives many seminars worldwide on a regular basis. With over forty Centers of Excellence globally, R3 is at the forefront of regenerative therapies.
R3’s Centers have successfully performed over 24,000 regenerative procedures to date. Call today for your free consultation (844) GET-STEM!
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The information provided by R3 Stem Cell is not a substitute for professional medical advice, diagnosis, or treatment. Individual results may vary and only your medical professional can explain all the risks and potential benefits of any therapy based on your circumstances. R3 Stem Cell does not recommend or endorse any specific tests, products, procedures, opinions, or other information that may be mentioned on this website. Reliance on any information provided by R3 Stem Cell, its employees, others appearing on this website at the invitation of R3 Stem Cell, or other visitors to the website is solely at your own risk. R3 Stem Cell is not responsible for the outcome of your procedure. The FDA considers stem cell therapy experimental at this point.
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