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Stem Cell Treatment for Erectile Dysfunction (ED)
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Disclaimer:
The information provided by R3 Stem Cell is for educational purposes and is not a substitute for professional medical advice, diagnosis, or treatment. Individual results may vary and are not guaranteed. The FDA considers stem cell therapy experimental at this point.
Any claims made on this website refer to procedures performed OUTSIDE of the USA. R3 Stem Cell has clinics in Mexico, Philippines, South Africa, Turkey, India, Pakistan.
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Every day, R3 Stem Cell receives inquiries worldwide from individuals asking if stem cell therapy for erectile dysfunction can help with ED. Spoiler alert: It can help a lot! In this guide, we’ll go through the basics of how stem cells work for ED, the latest research, and what to expect with a regenerative procedure.
Male sexual arousal is actually a complicated process that involves the brain, nerves, muscles, blood vessels, and emotions. Erectile Dysfunction (ED) is defined as the inability to get or keep an erection.
Around age 40, about 40% of men say they have some sexual dysfunction. This percentage increases by 10% with each decade of life, meaning 50% by age 50, 60% by age 60, and 70% by age 70. That’s crazy, right? By 2025, approximately 322 million men worldwide will be diagnosed with ED.
ED is associated with many risk factors including:
These typically lead to a blood flow problem to the penis.
Find Your Personalized ED Solution! Call R3 Stem Cell at +1 (844) GET-STEM for customized therapy and take control of your health today.
While there are several oral medications available that may facilitate the ability to achieve an erection, the obvious preference for men is to maintain the ability for spontaneous erections.
Stem cell treatment for ED has been shown in numerous studies to display beneficial effects.
Erectile function involves a complex relationship between neurologic, vascular, hormonal, and psychological components. A person may suffer from a combination of reasons that together lead to ED. Here are the most common issues:
PHYSICAL
PSYCHOLOGICAL
According to the National Institute of Health, between 15% and 25% of men aged 65 suffer from ED. That number continues to increase with age!
Before letting the problem turn into the proverbial elephant in the bedroom, you should consider what the latest in modern medicine has to offer for a long-term solution. At R3 Stem Cell, our specialist doctors provide advanced stem cell treatment options tailored to your needs.
Discover effective ED solutions tailored to you! Book your FREE consultation at +1 (844) GET-STEM with our experienced doctor today.
Initially, a person should be evaluated with blood and urine tests to rule out abnormalities such as infection, elevated PSA levels, diabetes, and other conditions.
An overnight erection test is a straightforward assessment. Typically, men experience 3 to 5 erections during the night while they sleep. If the test shows normal erections, the underlying issue may be mental.
An injection test involves placing medication directly into the penis. This medication acts through vasodilation, increasing blood flow to the penis. If an erection occurs, then most likely the problem involves a blood flow issue.
An ultrasound evaluates blood flow to the penis. Currently, penile Doppler ultrasound is primarily used to assess the integrity of the vascular mechanism and exclude underlying arterial or venous insufficiency.
Treating ED may be as simple as implementing lifestyle changes. This would be considered a “low-hanging fruit” option:
These changes alone may help a person overcome ED. However, mental health can also play a significant role, with high levels of stress and anxiety being common factors.
A person may benefit from counseling to improve mental health and possibly medications as well.
Blood flow to the penis may also be increased with a vacuum device (penis pump) and/or shockwave therapy. While these options may take months to show results, they are effective in over two-thirds of patients, inducing new blood flow formation through different mechanisms.
As a last resort, a penile implant may provide a permanent solution for patients. If widespread vascular blockage is detected on ultrasound, vascular reconstruction surgery may also be an option.
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If a new technology such as mesenchymal stem cell and exosome therapy could provide a long term solution for ED, it would and should become first line therapy. A regenerative therapy that can initiate spontaneous erections, negate the need for medications or injections and is a safe option should receive consideration.
The first clinical study was published in 2010 by a Korean team. Umbilical cord stem cells (15 million) were injected in seven men aged 57–83 years with diabetes-related ED. The results revealed that the majority of their participants regained their morning erections within one month and maintained this for more than six months.
Moreover, their blood glucose levels decreased after two weeks, highlighting that human umbilical cord blood stem cell therapy provided positive outcomes in both ED and diabetes conditions.
Another significant study from 2016 evaluated for the first time the use of various stem cell numbers per injection. Yiou et al. in a Phase I pilot study reported the effects of a stem cell injection in patients with vasculogenic ED who had undergone a radical prostatectomy.
Specifically, they divided their participants in four groups and administered escalating doses of stem cells. Their results revealed that a significant improvement without serious side effects was observed in the patients who received the highest dose of stem cells at six months post-treatment. Blood flow was best and the erectile dysfunction outcomes were most improved with the higher doses.
A 2021 study out of Jordan evaluated umbilical cord stem cell injections for 22 diabetic patients with refractory ED. There were no patients who reported serious adverse effects. There were significant improvements in IIEF-5, EHS, peak systolic velocity (PSV) basal, and 20-min PSV, all over the follow-up time points in comparison to the baseline. Conclusion: This study showed the proven tolerability, safety, and efficacy of penile injections of allogeneic Wharton’s Jelly mesenchymal stem cells for the treatment of diabetic patients with ED.
In 2024, the European Society for Sexual Medicine performed a comprehensive review of available literature on Cell Therapy for Erectile Dysfunction. They looked at 19 studies totaling over 400 patients. Their conclusion stated: In conclusion, preliminary findings are available in favor of the efficacy and safety of Cellular Therapy in patients with erectile dysfunction or Peyronie’s disease, suggesting a potential application of cell therapy in these patients.
In R3’s experience, 90% of patients with ED achieve success with stem cell and exosome therapy. It’s an exciting option for patients!
Speak with ED Specialists Today! Call R3 Stem Cell at +1 (844) GET-STEM to get started.
R3 used to perform autologous therapies, where a patient’s own bone marrow or adipose stem cells were used. However, a lot of stem cells in one’s body are as old as that person is, and hence not very active. Their ability to successfully increase sufficient blood flow and allow for spontaneous erections is inferior to umbilical cord stem cells.
Specifically, the therapeutic potential of autologous bone marrow or adipose stem cells in the treatment of older patients (such as ED patients) is impaired by a number of age-related factors such as oxidative stress, telomere length, DNA damage, disease, and long-term use of some medications.
This is in stark contrast to the youthful genotype and phenotype of neonatal tissue-derived stem cells, such as from the umbilical cord. They are better at facilitating repair and regeneration of tissue damage, creating new blood flow with superior anti-inflammatory and immunomodulatory efficacy compared to mature stem cells from one’s adipose or bone marrow.
As a result of the inferiority of autologous stem cells due to the reasons above and better results being seen with umbilical cord stem cells, R3 only uses donor stem cells today.
Stem cells and exosomes act in the body through several mechanisms. They do NOT become part of a patient’s DNA, which means they do not engraft into the person’s existing cells. The predominant method of action is thought to be through paracrine mechanisms, which means “cell to cell” interaction.
They act through:
Angiogenesis
provokes the formation of new blood vessels.
Reduce inflammation
lack of blood flow to the penis is associated with significant inflammation, and the regenerative biologics reduce it nicely.
Immune system modulation
the stem cells and exosomes modulate the immune system very differently than steroids. Instead of blanketly suppressing the immune system, the regenerative biologics tamp down the harmful processes while amping up the beneficial ones. This includes ramping up the production of several helpful growth factors and cytokines while tamping down harmful ones. 4. Cellular signaling – the biologics are able to perform “cell to cell” communication. This promotes recipient cells to proliferate their growth factor production, protein production and regenerate tissues that are damaged.
Prevent cell death
most cells have a timed death, where they are only allowed to live a certain length of time. This is called apoptosis. The regenerative biologics allow normally functioning cells to live longer, and spare them from the pre-programmed death.
Preventing scar tissue
Peyronie’s disease patients may experience significant scarring throughout the penis. Once that scar tissue forms, it becomes nonfunctional. Stem Cells and exosomes are great at preventing scar tissue (anti-fibrosis).
Stem Cells can also release a huge variety of molecules into the extracellular environment. These molecules, which include extracellular vesicles, lipids, free nucleic acids, and soluble proteins, exert crucial roles in repairing damaged tissue.
Along with offering MSCs for the treatment of erectile dysfunction, R3 Stem Cell includes stem cell exosomes, which are a type of extracellular vesicle participating in extensive cell to cell communication for new blood flow creation.
Looking for real results? Reach out to R3 Stem Cell at +1 (844) GET-STEM and see how our ED therapies can help you take charge confidently.
R3 Stem Cell’s regenerative biologics originate from umbilical cord tissue that has been donated after a scheduled c-section. No baby (or mother) is harmed during the c-section procedure. The umbilical cord tissue is normally discarded, but if the mother passes screening tests then the umbilical cord is immediately sent to the lab. The screening tests are extremely rigorous, and mandated by the USA FDA.
The lab carefully processes the umbilical cord to generate large amounts of stem cells and exosomes that are of the highest quality possible.
The lab team consists of multiple PhDs working in ISO Certified, cGMP compliant clean rooms to ensure quality assurance that exceeds USA FDA standards. The proprietary production process combines the highest potency, safety, and affordability for providers to confidently offer exosome therapy procedures.
Millions of dollars have been invested into the pharmaceutical grade production of biologics including first rate clean rooms, bioreactors, nano-particle tracking analyzers, cytometers, PCR, tangential flow machines and real time environmental monitoring. The quality assurance testing complies with screening and testing standards consistent with the American Association of Tissue Banks, cGMP standards, FDA regulations and the highest level of any regulatory agency globally.
R3 Stem Cell’s Centers of Excellence globally include umbilical cord stem cell derived exosomes with umbilical cord stem cells to provide enhanced results. Exosomes are lipid bound vesicles (acellular) produced by cells which contain a plethora of growth factors, cytokines, mRNA and other proteins.
They are exceptionally helpful in cell to cell communication, and very effective for reducing inflammation when they become ingested by their recipient cell. They act as shuttles to send nucleic acids and proteins to other cells, in this way, allowing cell-to-cell communication and transporting molecules among both close and distant cells. In general, these released proteins are important regulators of intracellular information.
Exosomes could be the mediators of many stem cell associated therapeutic activities. We have seen them to be “faster acting” than stem cells, so R3 frequently uses them in conjunction to provide a “1-2 punch” for patient outcomes.
After a decade of performing over 25,000 stem cell procedures worldwide, R3 is confident that regenerative procedures are safe. The quality control employed during stem cell production is unparalleled, and the side effects observed at R3 are usually mild to moderate and temporary.
Possible side effects may include:
These effects are typically temporary. If a patient has an allergic reaction to a multivitamin or a preservative, all of R3’s Centers have the necessary medications to resolve it quickly.
One common question is, “Will the stem cells get rejected?” The answer is NO.
Mesenchymal stem cells (MSCs) do not express major histocompatibility complex (MHC) antigens of the class II subtype and contain low levels of MHC molecules of the class I subtype. MSCs also lack the co-stimulatory molecules essential for immune detection, including CD40, CD80, and CD86.
Therefore, MSCs generally have low immunogenicity and can avoid immune rejection by the recipient. This characteristic serves as the foundation for their successful application without needing to match the donor to the recipient. Scientists refer to this phenomenon as being “immunologically privileged.”
Another frequently asked question is, “Is there a chance of tumor formation?” Current research concludes that the answer is NO. The mesenchymal stem cells and exosomes used during treatment have never been shown to possess tumor-forming potential; in fact, they have demonstrated anti-tumor properties.
Proven results, natural solutions. Explore stem cell therapy for ED at R3. call +1 (844) GET-STEM now!
For the past decade, R3 has been successfully treating erectile dysfunction with stem cell and exosome injections. The penis is numbed, so the procedure is virtually painless and tolerated well.
A temporary tourniquet is placed at the base of the penis so that the biologics will stay in the penis. Otherwise, the biologics may simply shift to systemic circulation. R3’s specialists use approximately 20 million stem cells and 50 billion exosomes for the procedure. PRP, short for platelet rich plasma therapy, is also included at no additional charge. The procedure takes less than an hour!
Exosomes could be the mediators of many stem cell associated therapeutic activities. We have seen them to be “faster acting” than stem cells, so R3 frequently uses them in conjunction to provide a “1-2 punch” for patient outcomes.
Similar to the research mentioned above, R3 Stem Cell’s outcomes for ED have been exceptional! The patient satisfaction rate is 85% year over year. Patients typically experience spontaneous erections that are maintained through penetration and intercourse. Keep in mind results cannot be guaranteed and will vary between individuals.
It may take a couple of months to see all the improvements, as it can take that long to build up new blood flow. It should be noted, again, that stem cell therapy is not a cure for ED, and will need to be repeated every 12 months or so for continued benefit.
Because stem cell treatment for ED is not a permanent cure, it’s important to make it affordable. Repeat therapies can help maintain and/ or achieve additional improvements for sexual health. So a lot of patients seek additional treatments at R3 Stem Cell every twelve to eighteen months.
R3 Stem Cell’s fees are less than half what comparable (and reputable) regenerative clinics charge. Be wary of clinics trying to pass off PRP as a stem cell therapy. If they mention only taking your blood for the treatment, it is NOT a stem cell treatment!
For the past decade, R3 Stem Cell’s Centers globally have performed over 25,000 regenerative procedures in six countries. Several hundred have been for ED, along with Peyronie’s disease. Patient satisfaction across all conditions treated is 85%!
R3 combines safety, effectiveness and affordability for the therapies. Internationally, the Intellicell is used, which is culturing the most active mesenchymal stem cells to create the “smartest” stem cell in the world!
Start Your Recovery Today! Reach out to R3 Stem Cell at +1 (844) GET-STEM to discuss your ED Treatment options.
This guide’s education does not constitute medical advice. The USA FDA considers stem cell therapy experimental.
References
R3 Stem Cell offers FREE consultations for individuals to discuss whether regenerative therapy is indicated for their ED. Simply call +1 (844) GET-STEM or +1 (480) 808-7057 to schedule yours!
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The information provided by R3 Stem Cell is not a substitute for professional medical advice, diagnosis, or treatment. Individual results may vary and only your medical professional can explain all the risks and potential benefits of any therapy based on your circumstances. R3 Stem Cell does not recommend or endorse any specific tests, products, procedures, opinions, or other information that may be mentioned on this website. Reliance on any information provided by R3 Stem Cell, its employees, others appearing on this website at the invitation of R3 Stem Cell, or other visitors to the website is solely at your own risk. R3 Stem Cell is not responsible for the outcome of your procedure. The FDA considers stem cell therapy experimental at this point.
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