Dementia

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Stem Cell Therapy for Dementia and Alzheimer’s

 

Alzheimer’s disease (AD) is also known as senile dementia of the Alzheimer type (DAT). This condition is caused by deterioration of brain tissue due to toxic proteins. Also, stroke-induced dementia accounts for 85% of all dementia cases. Dementia is a degenerative disease characterized by general impairment of cognitive functioning, and this results in lasting brain damage. In the U.S., 1 out of 8 seniors suffer from some form of dementia, and over 5 million Alzheimer’s patients are currently receiving medical care in America.

Because dementia is currently irreversible, researchers and scientists are investigating the use of stem cells to reverse, slow, or stop progression of dementia. While few studies have been conducted involving human subjects, much promising results have been noted in animal studies. The experts have proven that stem cell therapy can be used safely to treat dementia patients.

Animal Studies involving Stem Cell Therapy

In a recent study, overexpressing human neural stem cells were transplanted into animal models. The rat subjects had dementia. Researchers confirmed that memory and learning functions were fully restored following stem cell therapy. In addition, the volume of acetylcholine in the spinal fluid increased, and the cells migrated to the appropriate brain regions. In addition, researchers noted improved nerve growth factor in the brain region of the injected mice. The stem cells also showed further neuroprotective effects against cytotoxic agents.

Another clinical study found increased neuronal survival and microglia (brain cell) activation following administration of stem cells. Researchers of this study reported on the promise for improving recover in Alzheimer’s disease when stem cells are used. Mesenchymal stem cells (MSCs) promote survival, help restore brain activity, and increase needed metabolic activity. When human stem cells were placed in mouse subjects’ brains, they also were found to improve memory and alleviate dementia pathology. Another study showed that mouse stem cells modified to express certain proteins that helped with degenerative brain function. The stem cells also improved dementia by reducing toxin deposit and decreasing inflammation.

Human Studies involving Stem Cells for Dementia

A renowned neurologist in Korea has been conducting research using stem cells in animal subjects. Human umbilical cord blood mesenchymal stem cells have been found to significantly reduce amyloid plaques in the brain. The doctor said the biggest challenge for him was to decide what method of administration was best.

Intracellular microtubule-associated protein within neurons is important for axonal transport (sending of brain messages), as well as for structural support. In a human study involving stem cell transplantation, an 80-year-old woman, suffering from dementia, was treated. The stem cells were collected from the patient’s own bone marrow, and then were injected directly into her cerebral circulation. After treatment, the increased blood vessel flow was remarkable.

According to early findings in human studies, there are several advantages of using stem cell therapy over other dementia treatments. These include:

  • Avoidance of allergic and/or immune reactions (patient’s own cells suit genetic/chromosomal structure).
  • Does not require general anesthesia.
  • Side effects and rejection free.
  • No risk of transmissible diseases.
  • Quick, simple procedure.
  • Adult stem cells are superior to embryonic, so there are no ethical concerns.

R3 Stem Cell offers stem cell therapy for dementia, such as with Parkson’s disease. Prior to the 1990’s, it was widely believed that the brain did not have stem cells. In 1992, however, several international research groups showed that the human brain does in fact have stem cells. This meant that humans do in fact make nerve cells through life.

One strong theory that has been put forth regarding Alzheimer’s and other types of dementia involved abnormal protein deposits. These can be either with Lewy bodies or amyloid proteins. The protein deposits are theorized to affect the ability of the body’s stem cell’s to produce new nerve cells. The addition of additional stem cells with regenerative therapies may be able to overcome this dysfunction and help with dementia symptoms!

If you would like to see if you are a candidate for stem cell treatment for dementia, contact us today HERE or call (844) GET-STEM.

Resources

Bae JS, Jin HK, Lee JK, et al. Bone marrow-derived mesenchymal stem cells contribute to the reduction of amyloid-β deposits and the improvement of synaptic transmission in a mouse model of pre-dementia Alzheimer’s disease. Curr Alzheimer Res. 2013;10:524–531.

Chang KA, Kim J, Kim S, et al. Therapeutic potentials of neural stem cells treated with fluoxetine in Alzheimer’s disease. Neurochem Int. 2012;61:885–891.

Choi SS, Lee SR, Kim SU, & Lee HJ (2014). Alzheimer’s Disease and Stem Cell Therapy. Exp Neurobiol, 23(1), 45-52.

Kim JY, Kim DH, Kim JH, et al. Soluble intracellular adhesion molecule-1 secreted by human umbilical cord blood-derived mesenchymal stem cell reduces amyloid-b plaques. Cell Death Differ. 2012;19:680–691.

Lunn JS, Sakowski SA, Hur J, & Feldman EL (2014). Stem Cell Technology for Neurodegenerative Diseases. Ann Neurol, 70(3), 353-361.

Magga J, Savchenko E, Malm T, et al. Production of monocytic cells from bone marrow stem cells: therapeutic usage in Alzheimer’s disease. J Cell Mol Med. 2012;16:1060–1073.

Njie eG, Kantorovich S, Astary GW, et al. A Preclinical Assessment of Neural Stem Cells as Delivery Vehicles for Anti-Amyloid Therapeutics. PLoS ONE. 2012;7:e34097.

Yang H, Xie Z, Wei L, et al. Human umbilical cord mesenchymal stem cell-derived neuron-like cells rescue memory deficits and reduce amyloid-beta deposition in an AβPP/PS1 transgenic mouse model. Stem Cell Res Ther. 2013;4:76.

Zilka N, Zilkova M, Kazmerova Z, et al. Mesenchymal stem cells rescue the Alzheimer’s disease cell model from cell death induced by misfolded truncated tau. Neuroscience. 2011;193:330–337.

Amniotic and Umbilical Cord Stem Cell Treatments

The most revolutionary regenerative medicine treatments now being offered include amniotic and umbilical stem cell treatments. These are FDA regulated and contain growth factors, hyaluronic acid, cytokines and stem cells.

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