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Author Archive: David Greene

R3 Stem Cell Now Offering a Free Cryogenic Freezer Program

The nation’s leader in regenerative therapies, R3 Stem Cell, is now offering providers a free cryogenic freezer program. The program is offered to R3’s Partners, and does not involve any up front investment. The cryogenic freezers keep the regenerative biologics at temperatures of -80 degrees Celsius, which keeps the material viable containing millions of viable regenerative cells.

One of the main benefits of the cryogenic stem cell freezer is that practices have the biologic on hand when needed. Procedures with amniotic or umbilical cord stem cell material don’t have to be delayed due to any necessary overnight shipping. In addition, R3 outfits each freezer with a temperature probe for continuous monitoring. The monitoring logs continuously, so there is a record of everything and if the power goes off everyone gets notified through text and email.

R3’s Partnership Program is a comprehensive offering that includes patient acquisition, sales training, first rate biologics, seminars, protocols and provider training. Essentially the program includes everything necessary for a practice to implement a turnkey regenerative medicine program.

Here is an overview of the R3 Stem Cell Cryogenic Freezer Program. Call us today at (844) GET-STEM for more information and to get started!

Rod’s Bone on Bone Shoulder Pain Gone After Stem Cell Therapy

Rod is a 53 year old patient in Omaha NE who has been suffering for years from shoulder pain due to bone on bone shoulder arthritis. As an owner of a construction company and father to four active kids, Rod’s quality of life professionally and personally was severely diminished.

It had gotten to the point where Rod’s wife even had to help him put the belt on his pants every morning because of the pain!

As you’ll see in the video, Rod underwent nonoperative stem cell therapy at the R3 Stem Cell Center of Excellence in Nebraska. The results have been astounding!

No joint replacement. No year long recovery. And now… NO PAIN:) His story is very common. We see patients every day who have amazing outcomes even with severe bone on bone arthritis. Not just for the shoulder, but also for the hip, knee, ankle, elbow/wrist and the spine.

 

Don’t wait any longer, call R3 Stem Cell today at (844) GET-STEM to get set up with a free consultation. We have over 30 Centers nationwide that have completed over 10,000 successful stem cell procedures. You can be next!

 

Stem Cell Therapy for Alzheimers

Stem Cell Therapy for Alzheimer’s Disease

 

Alzheimer’s disease (AD) is characterized by progressive loss of cognitive functioning. There are currently 36 million people afflicted by this condition worldwide, and that number is expected to triple by the year 2050. Treatment of AD poses many challenges, as it is degenerative and not curable. Stem cell therapy has shown some promise in treating AD, and many recent studies support the use of stem cells as a viable option for Alzheimer’s disease.

Stem Cells for Alzheimers

Stem cells have been used successfully to counteract the symptoms of AD. Multipotent stem cells can differentiate into many cell types, such as oligodendrocytes, astrocytes, and neurons. These cells are derived from umbilical cord tissue and blood, amniotic fluid, bone marrow, and adipose (fat) tissue. With cell technology, stem cells can generate differentiate into types of glial and neuronal cells that are needed in AD treatment.

 

How Stem Cells Work

 

In mouse subjects with AD, studies show that transplanted stem cells change into mature cell types that improve memory and learning. One clinical study showed improvements of cholinergic neuron numbers, as well as memory in such AD rats after being transplanted with stem cells. It is thought that differentiation, maturation, and integration of the stem cells lead to secreted factors that signal molecules to stimulate cholinergic neurogenesis, and possible, prevent further loss. It has been shown that stem cell grafts increase brain-derived neurotrophic factor levels, and also, lead to behavioral rescue in mouse models of AD.

 

Grafted stem cells also are thought to work by altering the microenvironment in animal subjects’ brains. This process may have a negative impact on the therapeutic effect of stem cell transplantation. Nerve growth factors could promote survival of the cells, and stem cells transduced with human nerve growth factor genes can integrate into the cerebral cortex of AD rats to enhance cognitive performance. Transplantation of stem cells is used to deliver potent therapeutic agents, as well. These include insulin-degrading enzyme, neprilysin, plasmin, and cathepsin B.

 

Stem Cell therapy for AlzheimersNeural stem cells express high levels of neurotrophins, such as NGF and BDNF. Stem cells deliver neurotropins to the diseased brain, possibly modulating endogenous synaptic plasticity and enhancing survival of neurons. Many clinical studies support this notion, and stem cell transplantation has also been seen to increase hippocampal synaptic density and improve learning and memory in many transgenic models. The enhancement of synaptic growth was found to reduce neuronal loss and elevate levels of glial-derived neurotrophic factor within the brain.

 

Chronic inflammation is thought to play an important role in AD. Certain stem cell populations can exhibit robust anti-inflammatory properties. Stem cells have been found to induce expression of certain anti-inflammatory factors, such as prostaglandin E2 and interleukin-10. Peripheral administration of human umbilical cord blood stem cells was shown to reduce AD pathology by a mechanism that involves modulation of CD40 signaling. There is growing evidence that stem cells will also modulate the immune system. Because AD is an inflammation-associate condition, stem cells may reduce migrogliosis and expression of proinflammatory cytokine tumor necrosis factor. A few clinical studies suggest that mesenchymal stem cells can positively influence inflammation in AD models.

 

Clinical Studies

 

In a research study, embryonic stem cells were evaluated, a murine brain injury received a transplantation. The cells were capable of maturing into cholinergic and GABAergic neuronal subtypes and synaptically integrated with host neuronal circuits. This lead to improvements in impaired spatial memory and learning. Stem cells were also found to work in a rodent model study to decrease neuroinflammation, reverse cognitive deficits, and attenuate certain neuropathology. Intravenously, stem cells are capable of crossing the blood-brain barrier, and they can migrate to regions of neural injury. This has been done successfully in several studies.

 

Researchers recently used umbilical cord blood stem cells in an open-label phase I clinical trial. Nine patients with AD were given treatment. At three months, no patient had any serious adverse event from surgical transplantation of stem cells. Umbilical cord stem cells were also used to express high levels of angiogenic growth factors, which shown migratory activity. Overall, stem cell therapy for AD has enormous promise but more research is needed. MSC-based therapies have been best for human clinical trials.

 

Bone marrow stem cells have been found in one study to increase in number of positive cells for choline acetyltransferase. In addition, these cells removed AB plaques from the hippocampus and reduced substance deposits in AD mouse models. Human stem cells were found to enhance autophagy, promote AB clearance, and increase neuronal survival in another study. Intravenously injected stem cells were found in the brain for up to 12 days following the injection in animal models, and one report suggested that adipose-derived MSCs improve ACH levels, cognitive function, and locomotor ability in aged mice. The beneficial effects of stem cells were also associated with activation of M2-like microglia.

 

R3 Stem Cell offers regenerative therapy for Alzheimer’s disease at several of its 34 Centers nationwide. Call (844) GET-STEM today for a complimentary consultation to see if you are a candidate!

 

Resources

Chen WW & Blurton-Jones M (2012). Concise Review: Can Stem Cells be used to Treat or Model Alzheimer Disease? Stem Cells, 30(12), 2612-2618.

Chen J., Tang Y.X., Liu Y.M., Hu X.Q., Liu N., Wang S.X., Zhang Y., Zeng W.G., Ni H.J., Zhao B., et al. Transplantation of adipose-derived stem cells is associated with neural differentiation and functional improvement in a rat model of intracerebral hemorrhage. CNS Neurosci. Ther. 2012;18:847–854. doi: 10.1111/j.1755-5949.2012.00382.x.

Darlington D., Deng J., Giunta B., Hou H., Sanberg C.D., Kuzmin-Nichols N., Zhou H.D., Mori T., Ehrhart J., Sanberg P.R., Tan J. Multiple low-dose infusions of human umbilical cord blood cells improve cognitive impairments and reduce amyloid-β-associated neuropathology in Alzheimer mice. Stem Cells Dev. 2013;22:412–421. doi: 10.1089/scd.2012.0345.

Duncan T & Valenzuela M (2017). Alzheimer’s disease, dementia, and stem cell therapy. Stem Cell Res Ther, 8, 111.

Ha S., Ahn S., Kim S., Joo Y., Chong Y.H., Suh Y.H., Chang K.A. In vivo imaging of human adipose-derived stem cells in Alzheimer’s disease animal model. J. Biomed. Opt 2014;19:051206.

Honmou O., Houkin K., Matsunaga T., Niitsu Y., Ishiai S., Onodera R., Waxman S.G., Kocsis J.D. Intravenous administration of auto serum-expanded autologous mesenchymal stem cells in stroke. Brain. 2011;134:1790–1807.

Lee J.K., Jin H.K., Bae J.S. Bone marrow-derived mesenchymal stem cells reduce brain amyloid-β deposition and accelerate the activation of microglia in an acutely induced Alzheimer’s disease mouse model. Neurosci. Lett. 2009;450:136–141. doi: 10.1016/j.neulet.2008.11.059.

Salem A.M., Ahmed H.H., Atta H.M., Ghazy M.A., Aglan H.A. Potential of bone marrow mesenchymal stem cells in management of Alzheimer’s disease in female rats. Cell Biol. Int. 2014 doi: 10.1002/cbin.10331.

Shin J.Y., Park H.J., Kim H.N., Oh S.H., Bae J.S., Ha H.J., Lee P.H. Mesenchymal stem cells enhance autophagy and increase β-amyloid clearance in Alzheimer disease models. Autophagy. 2014;10:32–44.

Tong LM, Fong H, & Huang Y (2015). Stem cell therapy for Alzheimer’s disease and related disorders: current status and future perspectives. Experimental & Molecular Med, 47, 151.

Yang H., Xie Z., Wei L., Yang S., Zhu Z., Wang P., Zhao C., Bi J. Human umbilical cord mesenchymal stem cell-derived neuron-like cells rescue memory deficits and reduce amyloid-β deposition in an AβPP/PS1 transgenic mouse model. Stem Cell Res. Ther. 2013;4:76. doi: 10.1186/scrt227

Read This Before Considering Bone Marrow Stem Cell Therapy

There are ISSUES with Bone Marrow Stem Cell Procedures

It’s important before undergoing a bone marrow stem cell therapy procedure that you truly understand a few facts. First of all, it should be obvious that the procedure involves you being the donor of the bone marrow. The provider will harvest the bone marrow from your pelvis. While the risk of infection is small and there is no risk of rejection, those are not advantages compared with other types of stem cell treatment. For instance, amniotic and umbilical cord tissue don’t cause rejection either, and the risk of infection is minimal.

Bone Marrow Procedures OFTEN Cause Chronic Pain

 

The first consideration with this is that the needle used for the harvest is fairly large and it is going through an extremely sensitive area. The covering of your pelvis has a ton of nerve endings and may hurt significantly with the procedure. In fact, several studies have shown up to a 40% incidence of chronic pain after a bone marrow harvesting. Can you imagine having successful knee pain relief only to trade it for pain in your hip area chronically?

 

The Amount of Stem Cells in Your Bone Marrow is a PROBLEM

 

The biggest concern with using bone marrow for stem cell procedure is simply a matter of numbers. Once a person reaches the age of 50, the amount of stem cells in one’s bone marrow literally drops off a cliff. There is an exponential drop in the number of stem cells and other regenerative cells that are available. At the age of 50, there is a 90% drop in stem cells in one’s bone marrow, and by the age of 70 that drops by 97%!

 

Bone marrow stem cell procedure’s can work very well for those in their 20s and 30s. This would include athletes and those in categories such as post traumatic extremity arthritis. But for those who have degenerative arthritis and are over the age of 50, it is a TERRIBLE idea to consider bone marrow stem cell therapy.

Bone Marrow Stem Cells Get Lazy

 

 

Another interesting fact that has come from research out of Case Western Reserve University in Cleveland, is that stem cells from the bone marrow do not work as well with increasing age. So in addition to their being a quantity problem, there is also a quality issue as well. The stem cells that we make get lazy, and there are also not enough of them as we age.

 

The argument that you should have a bone marrow procedure because it is your own tissue is also not valid. Donated tissue from the amniotic fluid, placenta or umbilical cord does not get rejected in the human body. The reason is that during processing, any DNA factors are removed. This leaves the tissue immunologically privileged. In over 10,000 cases to date, our Centers of Excellence have never had a rejection, disease transmission, or a deep infection.

 

The stem cell and regenerative counts in the tissue are exponentially higher than what is seen with bone marrow or adipose. I will cover adipose in a separate article.
With over 30 R3 Stem Cell Centers of Excellence nationwide, R3 is the nation’s leader in regenerative procedures. Not only does this include arthritis and soft tissue conditions, but also neurodegenerative, auto immune, COPD, kidney failure and much more.

 

Simply call us today at (844) GET-STEM so we can set you up with a free consultation at a center close to you.

Read This Before Undergoing Adipose Stem Cell Therapy

Adipose Stem Cell Therapy Has a Critical Flaw

We get asked frequently how good adipose stem cell therapy works. Rather than offering a short answer, I’d like to elaborate on adipose (fat) as a regenerative tissue.
While in the body, adipose tissue has a ton of regenerative cells in it. These cells require considerable amounts of oxygen, which they receive as our fat has an excellent blood supply in the body.

Most Adipose Stem Cells Die After the Procedure

 

This is a critical difference between regenerative cells that come from the products of conception such as the placenta or the umbilical cord. Those tissues do not require a considerable amount of oxygen. When adipose tissue is acquired during a mini-liposuction and processed in the room for a stem cell procedure, a problem occurs. Once those stem cells are placed into the area being treated such as the knee or the hip joint, they receive very little oxygen in their new home. Research has shown that over 85% of those cells subsequently die within just a couple of days.

 

So people think they are getting these super high cell counts, when in reality most of those cells will never be able to live to do any of the necessary repair work. This is why adipose stem cell therapy has been losing popularity in the US for years!

 

What About Stromal Vascular Fraction (SVF)?

 

One of the modifications that centers sometimes offer for adipose stem cell therapy is to add some enzymes to the fat such as collagenase. This is the procedure called stromal vascular fraction. While this additional step does offer benefits, the FDA has come down hard on this procedure. In fact, they recently filed an injunction against over 100 Centers performing this adipose procedure modification. So it is actually not allowed by the FDA in the United States.

 

Even if the procedure were allowed in the US, no data has shown that adipose stem cell procedures (even as SVF) work better than umbilical or amniotic regenerative procedures. Plus there are potential risks from the liposuction procedure itself.

As a result, what we are seeing is that adipose stem cell therapy is rapidly falling out of favor in the United States. Over 99% of the individuals calling into our centers and being seen want to discuss either amniotic or umbilical cord tissue stem cell procedures. These procedures utilize donor tissue that does not cause a rejection in the body, is safe and is strictly regulated by the FDA.

 

R3 Stem Cell has over 30 centers nationwide that have performed over 10,000 successful procedures. And we have not seen any rejection, deep infection, allergic reaction or disease transmission. There are MILLIONS of live regenerative cells in the amniotic and umbilical cord tissue. Download our Consumer Guide HERE.

 

Call today (844) GET-STEM to sign up for a free consultation to see if you or a loved one is a candidate for stem cell therapy!

The Real Problem with Bone Marrow Stem Cell Therapy

There’s a lot written online these days about stem cell therapy using one’s own bone marrow. Some providers will say “you should only have your own bone marrow used, bone marrow is better for regenerative medicine,” etc. This is concerning as it’s mostly NOT a good idea.

When you really look at using one’s own bone marrow, there are TWO GLARING PROBLEMS that should be taken into consideration. The first issue simply comes

Young athletes are great bone marrow stem cell candidates

down to pure math. When a person is in his or her 20s or 30s, the amount of regenerative cells available is plentiful. For instance, when an athlete is considering undergoing a regenerative procedure, bone marrow may be an excellent option. For an individual in his or her 30’s with a post traumatic cartilage defect, it also makes sense to consider bone marrow procedures.

However, once a person reaches the age of 50, undergoing a bone marrow procedure is mathematically NOT a good idea. Studies have shown that the amount of stem cells available in one’s bone marrow drops exponentially as we age.

Specifically, by the age of 50, that amount drops by about 90%. By the age of 70, it drops by over 95%. In addition, researchers at Case Western have shown the stem cells that are still present do not function as well as those when a person is younger. Basically, stem cells in older individuals get LAZY.

Studies in the past have also shown a significant problem with what is obtained even under the best of circumstances with a bone marrow aspiration. With current techniques, the needle is placed into the iliac crest of the pelvis. Approximately 60 mL of bone marrow is aspirated for use.

What exactly is in that bone marrow?

That question has been answered by studies looking at the composition. The first 2 mL contains a decent amount of stem cells. Unfortunately, the rest of the 60 mL mostly consists of blood. This has very few stem cells and not very many regenerative cells either.

So in addition to age becoming a mathematical liability for the amount of cells we have available, the current techniques for aspiration hurt the situation even more.
The combination of the mathematical decay of the amount of stem cells we have available with aging, the decrease in function of what stem cells remain, and the current technical deficiencies with aspiration all add up to a sub-optimal regenerative procedure using one’s own bone marrow.

Complications with the Aspiration

And if that wasn’t enough to discourage people from undergoing a bone marrow procedure, consider the potential complications of the iliac crest aspiration. On average, studies show a 35% incidence of chronic pain from the aspiration. This means a person may have pain that last well over six months afterwards.

In addition, there have been reports of pelvic fractures, vascular injury, nerve injury and even a bowel perforation can occur. Imagine going in for a simple bone marrow stem cell procedure and ending up needing a blood transfusion and a bowel repair!

For the younger population, bone marrow should still be in the conversation. However, we simply have much better options available today for regenerative procedures. Umbilical cord and amniotic stem cell treatments have been shown in many peer reviewed studies to be safe and very effective for many conditions.

In over 10,000 cases performed over five years, R3’s Centers of Excellence have not experienced any disease transmission, deep infection, no rejection, and of course no chronic pain as no aspiration is necessary.

With umbilical cord tissue and amniotic fluid being obtained ethically and in accordance with FDA regulations, why risk any of the complications and poor cell numbers associated with a bone marrow procedure?

R3 Stem Cell offers effective regenerative procedures at over 30 Centers of Excellence nationwide. We also have a Concierge center in Las Vegas, where patients from around the country and internationally come for first-rate treatments.

Initial consultations, whether in person or over the phone, are offered complimentary along with an imaging review. Call us today at (844) GET-STEM and we will locate a provider close to you!

Does Stem Cell Therapy Work with Bone on Bone Arthritis?

One of the main questions we receive from individuals considering regenerative therapy for an arthritic joint is “Will the stem cell therapy work if I have bone on bone arthritis?” Interstingly, the answer is yes!

We didn’t always think it would help. When R3 first started over five years ago, we told providers it probably wouldn’t work. Thankfully, we were wrong! The outcomes proved to be exceptional over 80% of the time.

As the past five years have gone by and patient after patient has gotten dramatically better from the treatment, we have learned what is most likely happening with the joint treatment.

How Arthritis Occurs

 

Throughout life, people make cartilage at the same rate. It doesn’t matter whether a person is twenty or eighty, cartilage formation occurs consistently. The issue concerns the rate of cartilage loss. Unfortunately, with age comes an increased rate of cartilage loss. So the ratio of formation to loss turns into a mismatch.

This leads to an overall loss and degenerative arthritis. What’s being accomplished with a regenerative procedure (e.g. umbilical cord stem cell therapy), is putting the ratio back into the patient’s favor. It is NOT a cure or a complete fix, anyone who says that is not being realistic.

With the ratio being put back into the patient’s favor, cartilage formation can accumulate in a joint. Often times, noticeable joint improvement will occur on x-rays over time. It does not need to be a ton, simply a couple millimeters will usually be enough to create tremendous relief for patients.

How long will the relief last from a regenerative injection?

 

This is variable, and there is no set time frame. We have seen patients treated five years ago doing fantastic, while others may need a repeat treatment after a couple years. A person may not need another stem cell treatment, but may just benefit from a PRP treatment. The relief usually starts within the first month, and continues to improve for over six months.

There is no age limit to the treatment. R3’s Centers have seen patients upwards of age 102. The desire may simply be to walk farther, play more with the grandkids or play golf more often. Thankfully, the treatments are extremely safe in addition to being effective over 80% of the time.

How is Amniotic and Umbilical Cord Tissue Regulated?

 

Amniotic and umbilical cord tissue is strictly FDA regulated. During processing, any DNA factors are removed so it does not lead to rejection. The best labs, such as the ones R3 works with, ensure very high cell viability by not using radiation and only minimal preservative. This is one reason the outcomes at our Centers has been so amazing.

With the outcomes being so exceptional, over 95% of patients considering treatment at R3 now ask for amniotic and umbilical cord tissue treatment. Along with the outcomes, there is no need for harvesting so the potential for chronic donor site pain is avoided. When a bone marrow or adipose procedure is undergone, the potential for chronic donor site pain is over 30%, and with each year that goes by the regenerative cell counts in the human body decreases considerably.

 

R3 Stem Cell has over thirty Centers of Excellence nationwide. All of them offer a free consultation, and the providers are first rate. Call today to set up your visit to R3, where Regenerative Medicine is Made Easy!

R3 Stem Cell Founder Appears on Longstanding Radio Show Stepping In

For over 20 years, Nurse Jackie Tucker has been the host of Stepping In on KSCO in Santa Cruz CA. She discusses current healthcare topics with respected members of the healthcare community nationwide.

When R3 Stem Cell Founder and CEO David Greene, MD, MBA was asked to participate with Jackie on a recent show, he immediately said yes. “This is information people really want to hear, and Jackie’s got a great audience. She’s very professional and her reputation is stellar, so it took me about a nanosecond to say yes!”

Jackie asked questions about PRP and stem cell therapy, including applicability to several conditions. Amniotic stem cell therapy was discussed, along with opportunities for stem cell therapy to treat arthritis, tendonitis, burns, COPD, kidney failure and Alzheimer’s. The show lasted almost an hour.

To hear the entire show, simply click below!

Stem Cell and PRP Therapy for Heel Pain from Plantar Fasciitis

Heel pain from plantar fasciitis affects millions of Americans. Current, traditional treatment options include NSAIDS, night splints, cortisone injections, stretching and orthotics. All too often the heel pain becomes chronic and patients end up deciding on potentially risky surgery. Even if no complications occur, the outcome is pretty much a roll of the dice.

But all is not lost. Research is now showing that PRP and Amniotic stem cell therapy works very well for chronic heel pain from plantar fasciitis. In this video, R3 Stem Cell CEO explains the evidence available. Call us today for top treatment at (844) GET-STEM!

 

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