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stem cell therapy

Amniotic Stem Cell Therapy is for Real

I realize there are plenty of critics who write negatively about amniotic fluid treatment in regenerative medicine. Rather than writing a LONG blog post about why amniotic stem cell therapy is for real, here are some bullet points. Please watch the video below and you will understand why the treatment is the real deal.

  1. When processed properly, amniotic fluid DOES have viable stem cells. There are plenty of companies that radiate their product during processing, but the FDA does not require that. The video explains this nicely.
  2. You have to keep in mind those who consistently speak negatively about amniotic are promoting a competing product. So when you put it in perspective you can understand why they would want to find something negative. Amniotic stem cell treatment does not require harvesting, the treatment is fast, results have been fantastic and no rejection occurs.
  3. Naysayers harp on the fact that amniotic fluid is not FDA approved. The funny thing is it cannot be FDA approved because it is regulated as a biologic. It cannot be FDA denied either.

The bottom line is amniotic fluid in regenerative medicine has shown amazing outcomes. Another thing you will notice is you don’t need sedation for a harvesting, and the treatments are less expensive predominantly as a result. Watch the video below, then call (844) GET-STEM for treatment!

 

Stem Cell Therapy for Shoulder Conditions

While there is not a ton of research on stem cell therapy for shoulder pain, some studies have been published. This includes stem cell therapy for rotator cuff tears, tendonitis, SLAP lesion, shoulder arthritis, cartilage defects and more. In this video, R3 Stem Cell CEO Dr. David Greene explains outcomes that have been shown in the research. If you or a loved one needs stem cell therapy for shoulder pain conditions, call (844) GET-STEM today!

 

Stem Cell Therapy for Degenerative Disc Disease Back Pain

Stem cell therapy for degenerative disc disease is available and works according to recent research studies. In this video, R3 Stem Cell CEO David Greene MD explains the current research results. If you or a loved one is experiencing chronic back pain due to degenerative disc disease, call R3 Stem Cell today!

Stem Cell Therapy for Avascular Necrosis

Avascular necrosis of the hip or knee often leads to chronic, debilitating pain. To date there have not been enough nonoperative treatment options that provide effective relief. Stem cell therapy is proving to be a viable option. In this video, R3 Stem Cell CEO David Greene MD goes through the research on the topic. Call us for treatment today!

 

FAQs on Stem Cell Procedures for Elbow Tendonitis

Stem cell procedures are an excellent method to treat elbow tendonitis thanks to the natural repair and regeneration. Be it tennis elbow or golfer’s elbow, tendonitis is traced to chronic inflammation of an elbow tendon. Stem cell therapy can relieve pain in the short term and restore the damaged tendon in the long term.

What are stem cells?

Stem cells differ from all other cells in our body due to their ability to become most other cells. These cells replicate into cells found in the part of the elbow painbody where these are injected.

What is the source of stem cells used to treat elbow tendonitis?

Stem cells are sourced from the bone marrow, fat cells, or from amniotic fluid.

Fat and bone marrow are harvested from the patient him or herself. Amniotic fluid is harvested from a consenting mother after a scheduled c-section.

How does stem cell therapy treat elbow tendonitis?

Elbow tendonitis encompasses two types of injuries – tennis elbow (lateral epicondylitis) and golfer’s elbow (medial epicondylitis) – both have their origin in tendinitis or degeneration of musculature leading to chronic inflammation of elbow tendons. Tennis elbow occurs in the outer tendons, while golfer’s elbow affects the inner tendons.

Stem cells injected into the area of the injured tendon help to repair and regenerate the damage by converting into tendon cells, while also promoting new blood vessel formation.

How successful is stem cell therapy to treat elbow tendonitis?

Stem cell procedures for elbow tendonitis are popular with both golfers and tennis players.

  • A study carried out by the Jefferson-based Rothman Institute showed 61% of those treated with stem cell therapy for tennis elbow had significant improvement in pain and tenderness compared to 50% in the non-stem cell group over a period of 24 weeks.
  • A study attributed to researchers from South Florida attests the fact that stem cell procedures for elbow tendonitis brings down pain considerably and improves disability.
  • A Stanford University study published in 2006 claims 93% improvement in chronic elbow tendonitis when stem cell procedures are used.
  • A 2012 study reported 66% percent more pain relief from stem cell therapy compared to corticosteroid injections.

What are the advantages of stem cell therapy for elbow tendonitis compared to other treatments?tennis elbow

  • Healing by the human body itself
  • Non-invasive and no need for surgery
  • Complete and fast recovery
  • Outpatient procedure
  • Nonsteroidal

How are stem cells to treat elbow tendonitis harvested?

Stem cells used to treat elbow tendonitis are harvested from the bone marrow or one’s fat (adipose). The procedure takes about half an hour.

Amniotic fluid is obtained from consenting  mothers after a scheduled c-section. The fluid is then processed at an FDA regulated lab and cryogenically frozen until it’s time for the procedure. There are no rejection issues as the fluid is immunologically privileged.

How is the stem cell therapy for elbow tendonitis performed?

The skin above the tendon causing pain is numbed and stem cells are injected into the area. Often times, the needle is also used to “poke holes” in the bone too so bleeding is stimulated for repair. These stem cells start to multiply themselves soon after being injected. These new cells replace the old and damaged cells and anchor the repair job. The process goes on for months.maxresdefault

What are post-procedure cautions to be followed?

You may have to use an elbow sling for a day. Activity should be limited for approximately 48 hours, then resumed as tolerated.

What are the side effects of stem cell procedures for elbow tendonitis?

Complications are unusual and may include infection, bleeding or soreness.

Do I need more than one stem cell procedures for elbow tendonitis?

Patients usually need one stem cell procedure to treat elbow tendonitis. However, at times a second procedure may be necessary for optimal relief.

 

References

Singh A, Gangwar DS, Singh S. Bone marrow injection: A novel treatment for tennis elbow. Journal of Natural Science, Biology, and Medicine. 2014;5(2):389-391.

Lui PPY. Stem cell technology for tendon regeneration: current status, challenges, and future research directions. Stem Cells and Cloning : Advances and Applications. 2015;8:163-174.

Carvalho A de M, Badial PR, Álvarez LEC, et al. Equine tendonitis therapy using mesenchymal stem cells and platelet concentrates: a randomized controlled trial. Stem Cell Research & Therapy. 2013;4(4):85.

Ho JO, Sawadkar P, Mudera V. A review on the use of cell therapy in the treatment of tendon disease and injuries. Journal of Tissue Engineering. 2014;5:2041731414549678.

Young M. Stem Cell Applications in Tendon Disorders: A Clinical Perspective. Stem Cells International. 2012;2012:637836.

Top 5 Definitions in Amniotic Stem Cell Treatments

Stem Cell Injections, Growth Factors, Cytokines, Hyaluronic Acid – WHAT ARE THESE?

When looking at receiving amniotic stem cell treatment to avoid surgery for arthritis, tendonitis, sports injuries, or for wound care or cosmetic purposes, it helps to know what these terms mean. You don’t need to be a PhD, but at least having a basic understanding of the components of the treatment being received can’t hurt! In this video, R3 Stem Cell CEO David Greene explains what they mean.

When you’re ready for treatment, call us at (844) GET-STEM!

 

Why Is There Great Interest in Stem Cells?

Stem cells, which may be thought of as the body’s natural repair kit, have created a lot of interest amongst medical researchers and doctors. In practical application and experimental trials, these cells have been found to have great power and potential in treating a long list of health care issues, including stem-cellsinjuries to the musculoskeletal system, wound healing, neurological disorders and injuries, heart problems, cancer, and much more.

Practitioners are currently using stem cells to treat various health concerns such as rheumatoid arthritis; ligament, tendon, and bone damage; and wounds. It’s expected that in a few years that list will expand greatly. Needless to say, there is great interest in these amazing powerful and versatile cells. What are the various benefits that can be associated with stem cells? They are numerous.

Greater Understanding of Disease

It’s hoped that researchers and doctors in the lab can learn more about diseases, including how and why they happen, by observing stem cells as they mature to become muscles, nerves, bones, and other tissues and organs. Because stem cells contain the basic components needed to repair the body in that they are the healthy cells that replace those that are damaged or diseased, there’s great hope that we can gain new and important insights into diseases and injuries that will lead to breakthroughs in medicine.

Development of More effective Treatments

In understanding more about disease and injuries and how these cells work in repairing the body, scientists see a future where a wide range of health issues can be addressed with the use of new stem cell therapies. Healthcare challenges that may benefit from this new knowledge and developing therapies include those related to spinal cord injuries, heart disease, stroke, burns, type 1 diabetes, Parkinson’s disease, Alzheimer’s disease, cancer, and osteoarthritis.

Revolution in Transplant and Regenerative Medicine

There’s great interest in stem cells due to the promise they hold for the development of transplant and regenerative medicine. Because of their vast potential to be grown and cultivated into new tissue, stem cells may have applications of which we are not even aware. The entire manner in which we treat very serious conditions and diseases may change drastically and success rates could rise dramatically as stem cell therapies are developed.

R3 Stem Cell is at the forefront of offering regenerative medicine for all types of musculoskeletal conditions. Call us today!

What Are the Latest Research Finding About Stem Cell Therapy Benefits For Knee Arthritis?

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Stem cell therapy has emerged as the most promising treatment to stop and reverse the effects of degenerative disorders, such as knee arthritis. Research publications worldwide attest its effectiveness in fast becoming a non-invasive substitute to surgical method and an alternative source of knee cartilage cell regeneration.

Scientific studies show that stem cell therapy has higher success rate in improving pain and disability associated with knee arthritis compared to any other treatment. The bio-restorative procedure with its unique natural healing ability also stimulates the regeneration of the damaged knee cartilage reversing the effects of arthritis.

How does stem cell therapy treat knee arthritis?

Knee arthritis causes permanent damage to the articular cartilage. As a result, bones in the knee joint rub with each other as we walk or bend the knee. This leads to pain and disability.

Stem cells have the unique ability to self-renew themselves and replicate other cells. When these cells are harvested and injected into the knee affected by arthritis, it triggers redevelopment of the damaged cartilage. Stem cells increase in numbers by self-renewing and differentiating themselves into cartilage cells. These new cells gradually replace the damaged and dead cells and heal the injury. This allows redevelopment of the cartilage and reversal of the damage caused by knee arthritis.

Is stem cell therapy for knee arthritis an alternative to surgery?

Stem cell therapy is fast emerging an alternative to surgical treatment of knee arthritis. Non-invasive, it assures better and permanent healing, pain management, greater freedom from disability, and faster recovery. The procedure completely reverses the damage to the cartilage by helping it to regenerate and thus heals the degeneration associated with knee arthritis.

As stem cells are harvested from the body of the patient, these do not pose any risk of rejection. Once the healing is complete, you regain knee strength equal to the pre-arthritis level and lead a pain-free life for a significantly longer period. The degree and duration of relief is far superior to the outcome of any other treatment or pain management method.

What Does The Latest Research Show?

The latest research on stem cell therapy highlights its wider application to treat and reverse the damage caused by degenerative disorders. According to research findings published in the Expert Opinion in Biological Therapies, stem cells are able to renew the damaged knee cartilage and undo the effects of arthritis. In a wider study reported in the Clinical Journal of Sports Medicine, researchers discovered that almost a third of patients studied had their cartilage degradation completely reversed within 12 months of having the procedure.

The results of a pilot study published in 2013 termed stem cell therapy a breakthrough treatment for patients suffering from knee arthritis. It provides significant improvement relieving pain and disability without any hospitalization or invasive surgery. The Stem Cells journal claims accelerated healing and recovery from knee arthritis is possible when a patient is treated with stem cell therapy.

The outcome of an 18-patient study published in the Stem Cells Translational Medicine journal that asserts that “a single injection of stem cells reduces pain and inflammation” and “improves mobility.” All were French and German patients aged 50 to 75 and had debilitating arthritis symptoms in their knees, such as severe inflammation, considerable pain, and crippling disability, for more than 12 months. Divided in to three groups – low-dose, medium-dose, and high-dose stem – each had a single injection of stem cells. A review after six months revealed that all patients had improvements as far as the severity of pain, functional disability, and mobility are concerned. Researchers observed “statistically significant” recovery even in the group with the lowest dose.

An analysis of current research on pharmacologic and regenerative therapies for osteoarthritis published in the Bone Research journal (Mar, 2016) acknowledges stem cell procedure as a “long-term solution to repair and regenerate cartilage, alleviate symptoms and finally delay progression of osteoarthritis.”

Meanwhile scientists at the Whitaker Biomedical Engineering Institute in Johns Hopkins have successfully generated precursor cartilage cells from stem cells. Sponsored by the Arthritis Foundation, the project showcases the promise of creating new bone or cartilage that could replace or repair the damage to the knee caused by osteoarthritis.

Encouraged by the “bio-restorative” qualities of stem cell therapy, the Rush University Medical Center ran the first ever nationwide clinical study of Cartistem – a first of its kind cartilage regeneration stem cell drug – between 2013 and 2015. Injected in to the knee area, it is touted to repair knee cartilage damaged by osteoarthritis. The trial that ended in May 2015 was promising and a detailed outcome report is expected next year.

Researchers at the St. Louis-based Washington University School of Medicine have also developed a new stem cell technique that can resurface an arthritic knee joint. As reported in the Proceedings of the National Academy of Sciences journal, stem cells are programmed to develop a new cartilage that has anti-inflammatory molecules, which prevents reoccurrence of arthritis.

Mesoblast, a leader in stem cell medicines, made a presentation at 2016 Amsterdam World Congress of the Osteoarthritis Research Society International about its MPC-75-IA drug made to turn around effects of knee arthritis. The manufacturer claimed that a single shot of its product, an intra-articular stem cell injection, was capable of significantly improving “pain, disability, cartilage thickness, and joint structure within 24 months.”

R3 Stem Cell offers stem cell therapy for knee arthritis at clinics nationwide. Treatment is offered with amniotic stem cell therapy for knees, bone marrow and adipose derived stem cells. Call (844) GET-STEM today!

References

Yves-Marie Persa, Lars Rackwitzc, Rosanna Ferreiraa, et al. Adipose Mesenchymal Stromal Cell-Based Therapy for Severe Osteoarthritis of the Knee: A Phase I Dose-Escalation Trial. STEM CELLS Translational Medicine; May 23, 2016, sctm.2015-0245

Wei Zhang, Hongwei Ouyang, Crispin R Dass. Current research on pharmacologic and regenerative therapies for osteoarthritis. Bone Research 4, Article number: 15040; 01 March 2016

Franklin Moutosa, Katherine Glass, Sarah Compton. Anatomically shaped tissue-engineered cartilage with tunable and inducible anticytokine delivery for biological joint resurfacing. Proceedings of the National Academy of Sciences; August 2, 2016; vol. 113 no. 31

Stem Cell Therapy is the Future of Orthopedic Medicine

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Regenerative therapies for the musculoskeletal system are the future of orthopedic medicine. Stem cell therapy is an innovative treatment that heals musculoskeletal problems without the need for surgery. In the United States alone, there are more than 500,000 spinal fusions and 400,000 lumbar discectomies performed each year. To avoid surgery, many people are choosing alternate forms of treatment.

 

What are stem cells?

 

Stem cells are undifferentiated cells in the body that can become many specialized types of cells. Adult stem cells are different from embryonic stem cells in that they are derived from adults, usually the patient’s own body. Stem cells used to treat musculoskeletal problems are called mesenchymal stem cells (MSCs), which turn into cartilage cells and bone cells.

 

How does stem cell therapy work?

 

The stem cells are obtained from the patient by aspirating tissue from fat (adipose) or taking bone marrow solution bone-marrow-aspiration2from the hip bone (iliac crest). The cells are spun in a centrifuge machine to identify and separate the stem cells that help heal tissues. Stem cells are injected into the damaged or injured body structure, such as a tendon, ligament, or spinal disc.

The additional method of obtaining stem cells includes amniotic fluid. This is obtained from consenting mothers of those scheduled for a c-section. The fluid is processed at an FDA regulated lab and prepared for use.

 

 

How are the stem cells obtained?

 

The human body has many stem cell storage sites. The easiest method for obtaining stem cells is to remove them from the hip bone (iliac crest). The procedure is done at the physician’s office, and it begins with the patient lying face down on the exam table. The skin over the bone is cleaned with an antiseptic, then numbed using a lidocaine solution. Under x-ray guidance, a procedure needle is inserted into the bone’s cortex. The liquid marrow is then withdrawn into a syringe. After the needle is removed, a bandage is applied. After the procedure, the stem cells are processed in the laboratory to concentrate them.

 

What conditions are treated with stem cell injections?

 

Stem cell injections are often used for the treatment of:

 

  • Muscular tears
  • Chronic partial rotator cuff tears
  • Osteoarthritis of the shoulder, hip, knee, and ankle joints
  • Discogenic back pain
  • Meniscal and cartilage tears in the knee
  • Spinal facet pain
  • Chronic radiculopathy
  • Sacroiliac joint pain

 

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What risks are associated with stem cell treatments?

 

The risks associated with stem cell injections include infection, nerve damage, and bleeding. However, these incidents rarely occur. There is no risk for allergic reaction since your own stem cells are used during the procedure. We recommend only effective, safe procedures for our patients.

 

When will I notice benefit from the injections?

 

The benefit occurs 2-3 months following the whole therapy protocol. For most patients, 3-4 injections are necessary, and we usually will only perform 3 injections within a 12-month time span.

 

Do stem cell injections work?

 

In a very recent study, researchers followed 18 patients who suffered from osteoarthritis of the knee, ankle, and/or hip. Each of these patients received one stem cell injection and were followed by laboratory and MRI tests for several months. All 18 patients showed therapeutic benefits, such as decreased pain, increased walking distance, and improved function scores. In addition, MRI results improved. In 2011, a study involving 339 patients with knee osteoarthritis found that 60% of patients had pain relief after the stem cell therapy. In addition, only 6% still required a total knee replacement.

 

Resources

Centeno C, Schultz J, Cheever M. Safety and complications reporting on the re-implantation of culture-expanded mesenchymal stem cells using autologous platelet lysate technique. Curr Stem Cell. 2011;5(1):81–93. doi: 10.2174/157488810790442796.

Emadedin M, Ghorbani-Liastani M, Fazeli R, et al. (2015). Long-Term Follow-up of Intra-articular Injection of Autologous Mesenchymal Stem Cells in Patients with Knee, Ankle, or Hip Osteoarthritis. Arch Iran Med, 18(6), 336-344.

Pak J. Regeneration of human bones in hip osteonecrosis and human cartilage in knee osteoarthritis with autologous adipose derived stem cells: a case series. J Med Case Rep. 2001;5:296. doi: 10.1186/1752-1947-5-296.

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