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PRP Therapy

Top 5 Definitions in Amniotic Stem Cell Treatments

Stem Cell Injections, Growth Factors, Cytokines, Hyaluronic Acid – WHAT ARE THESE?

When looking at receiving amniotic stem cell treatment to avoid surgery for arthritis, tendonitis, sports injuries, or for wound care or cosmetic purposes, it helps to know what these terms mean. You don’t need to be a PhD, but at least having a basic understanding of the components of the treatment being received can’t hurt! In this video, R3 Stem Cell CEO David Greene explains what they mean.

When you’re ready for treatment, call us at (844) GET-STEM!

 

PRP Therapy for Bones and Joints

prp

Platelet-rich therapy (PRP) is being used in surgeries to promote cell regeneration since 1987. The procedure involves taking the patient’s own blood, processing it in the laboratory to concentrate the platelets, and injecting the platelets into the body.

 

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What are platelets?

 

 

Platelets are fragments of the megakaryocyte, which is a large cell in the bone marrow. Megakaryocytes differentiate and mature from stem cells, which retain the ability to renew themselves and turn into other specialized cells. In addition, platelets leave the bone marrow to circulate in the bloodstream. Platelets bring white blood cells to an injured area, facilitate blood clotting, release growth factors, and facilitate tissue regeneration.

 

Is PRP therapy proven to be effective?

 

There is much research to support that PRP therapy is effective for treating bone and joint conditions. Researchers studied 78 patients with knee osteoarthritis who received PRP injections. Compared to placebo saline injections, the study found that knees treated with PRP injections saw a reduction in stiffness and pain, and also, improved in function at the 3-month follow-up.

 

In a small study of patients with arthritic knees, MRI tests were used to evaluate joint damage following PRP injections. Patients receiving PRP injections had less pain after 12 months of therapy. In addition, MRIs showed that the degenerative process had not progressed in most patients who receive these treatments. The evidence also found that arthritis did not worsen, and patients had less pain than they did the previous year.

 

Am I a candidate for PRP therapy?

 

PRP does not help all patients with chronic pain, but it does work in certain situations. PRP appears to fail to treat symptoms in some people because of differences in PRP formulation and changes in certain variables, such as frequency of injections and the amount of PRP injected. PRP also does not appear to work for people with severe joint arthritis and degeneration.

 

How does PRP work?

 

When the concentrated platelet solution is injected into a damaged area, it stimulates the joint or bone causing mild PRP-2inflammation that triggers healing. As a result, new collagen forms, and as this collagen matures, it shrinks, tightens, and strengthens the body structures in the damaged area. The concentrated platelets also contain growth factors and bioactive proteins that initiate and accelerate tissue repair. These substances increase production of stem cells to stimulate connective tissue healing, bone repair and regeneration, and wound healing.

 

How does PRP compare to cortisone shots?

 

Cortisone shots offer only temporary pain relief by stopping inflammation. However, corticosteroids to not offer long-term healing like PRP. Studies show that PRP offers better tissue regeneration along with anti-inflammatory properties.

 

What body regions can be treated with platelet-rich platelet therapy?

 

PRP injections help regenerate many body areas, including the cervical (neck), thoracic (mid-back), and lumbar (low back) spine, elbows, shoulders, wrists, knees, hips, and ankles. Many orthopedic specialists use PRP therapy for sports injuries, degenerative joints, degenerative disc disease, and scoliosis.

 

How is platelet-rich plasma obtained?

 

Before a platelet-rich plasma procedure, the patient meets with the doctor for a consultation. After the decision to have PRP therapy is made, the blood is taken from the patient and placed in a special centrifuge. This device spins the blood to separate the platelets from the blood. After concentrating the platelets, the solution is injected into the damaged, injured, or degenerative body region.

An Overview of PRP Therapy: How It Works and What It Does

Platelet rich plasma (PRP) therapy is being utilized increasingly to help enhance and encourage the healing process for those who have soft tissue and bone injuries. PRP has received increased attention from the media as it has been used to help high profile athletes who have suffered injuries mend more quickly and efficiently. It has been effective in reducing inflammation and in boosting cell proliferation, both of which are important aspects of the healing process.

Defining PRP

PRP is derived from one’s own body, coming directly from a person’s blood. It uses one kind of cell that is found in the blood, platelets. PRP is a substance that has a heavy concentration of these cells, which circulate within the blood and are an important factor in clotting. Plasma, which is also found in our blood and is aprp2
component in PRP, is involved in providing the body with key substances. Together platelets and liquid plasma, which combine to create PRP, are important in that they possess certain factors that help in the enlistment, multiplication, and specialization of cells, all of which are essential to the healing process.

PRP Therapy

PRP therapy begins with blood being drawn from the patient; it is then placed in a centrifuge where it is spun in order to separate the blood into its various components. The plasma, which is platelet rich, is collected and treated prior to being administered to the injured region.

When a patient undergoes PRP therapy they are given injections in the area of injury. When administering the treatment a healthcare professional will often utilize ultrasound guidance to ensure accuracy in treating the specific bone or soft tissue region, which may be a designated ligament or tendon.

After the patient receives the injection, there is a short period of time where they will avoid all exercise. After that, they begin an exercise program designed to physically rehabilitate the injured area.

Efficacy of PRP

There is evidence based on scientific studies focusing on animals in which therapy that uses PRP has been revealed to be effective in aiding the healing of bone and soft tissue. As an example, in calf muscle injuries in which the Achilles tendon has been damaged there has been evidence of increased numbers of cells and heightened PRP-2tendon strength. Also, increased muscle regeneration has been noted.

There have also been promising but limited studies involving humans. PRP therapy was revealed to be efficacious in a small study focusing on knee osteoarthritis. In this study PRP was shown to be more effective than hyaluronic acid treatment. In addition, there have also been positive results in treatment with PRP that focuses on rotator cuff tears and medial collateral ligament (MCL) knee injuries.

However, there is also a study published in the Journal of the American Medical Association that noted there was no advantage to utilizing PRP injections when compared to placebo injections of saline for the treatment of Achilles tendinosis. Still, despite the lack of of evidence as to the efficacy of PRP, it has started to take root as a treatment that can aid in the healing process due to the fact that it carries an extremely low-risk and the substance used is derived directly from the patient’s blood.

With promising results in animal models, there has been increased activity in using PRP for various conditions, including chronic and acute tendon issues and injuries to muscles and ligaments. Conditions that have responded especially well to PRP include those related to lateral epicondylitis (tennis elbow) and Achilles tendinosis, which affects the Achilles tendon.

As more studies are developed regarding the use of PRP and more evidence becomes available as to its effectiveness, it’s anticipated that the therapy will become more widespread. Also, studies will go a long way to helping to standardize treatment.

Cautions Regarding Treatment

Although PRP therapy involves minimal risk, there are certain cautions that should be taken when utilizing this type of approach. When undergoing treatment all anti-inflammatory medications should be stopped, as PRP is designed to aid in the reduction of inflammation and aid in healing. Also, athletes who will be involved in certain competitions need to be aware that PRP contains endogenous growth factors, which certain agencies, such as the World Anti-Doping Agency and the United States Anti-Doping Agency, forbid. This is due to the possibility that PRP might enhance one’s performance, although there is no evidence of such.

Considering PRP Therapy

There are some important points to remember concerning platelet rich plasma (PRP) therapy, including that this is a substance that is extracted from the injured party’s blood, and comprised of components in their blood, specifically platelets and plasma. PRP contains a high concentration of growth factors (at least 7) and of those factors involved in cellular signaling, both of which are considered to be important in aiding the healing process.

An increasing amount of human studies are attesting to the effectiveness of PRP therapy for soft tissue injury, arthritis, tendonitis, ligament tear healing and more. Call (844) GET-STEM to find a PRP therapy treatment center today!

FAQs on PRP Therapy for Rotator Cuff Injury

What is rotator cuff injury?

Your shoulder is a ball and socket joint that connects your humerus (upper arm bone), scapula (shoulder blade), and clavicle (collarbone). The rotator cuff refers to the muscles and tendons that keep the shoulder in place, namely, the supraspinatus, infraspinatus, teres minor and subscapularis muscles and tendons that cover the head of the humerus.rotator cuff bursitis

The rotator cuff can be damaged from acute injury, or through progressive degeneration and overuse. The damage can range from muscle or tendon strain, to a tear of the rotator cuff tendons. Tears of the rotator cuff tendons can be partial or full-thickness.

What is the standard treatment of rotator cuff injury?

Conservative treatment options are preferred whenever possible for rotator cuff injury. If the injury is not too severe, it can be managed with a program of rest, ice therapy, compression and elevation. Analgesic medications can also be prescribed to relieve pain symptoms, as well as to reduce inflammation. Physical therapy and rehabilitation may be recommended to improve the strength and conditioning of the stabilizing muscles.

Patients suffering large or complete tears, or weakness and reduced functionality of the joint may require surgical intervention. While surgery usually results in decreased pain and improved function, significant failure rates are noted at long-term follow up consults. It is theorized that failure rates can be attributed to the poor vascularity and cellular infiltration of the tendon, leading to poor wound healing and repair.

How is PRP used in the treatment of rotator cuff injury?

Platelet-rich plasma therapy contains a high concentration of the following growth and repair factors:

  • platelet-derived growth factor
  • transforming growth factor beta
  • fibroblast growth factorShoulder pain
  • insulin-like growth factor 1
  • insulin-like growth factor 2
  • vascular endothelial growth factor
  • epidermal growth factor
  • Interleukin 8
  • keratinocyte growth factor
  • connective tissue growth factor

PRP is derived from the patient’s own blood: after drawing the necessary amount for PRP, the blood is concentrated in a centrifuge. The centrifuge splits the blood into three laters: (1) the top layer of plasma; (2) the platelets and white blood cells (also known as “the buffy coat”); and (3) the red blood cells. It is the second layer that is used for PRP.

PRP injections may be anywhere from three to eight times as concentrated as normal blood. This will be injected into the damaged area to stimulate growth and regeneration of health tissue, as well as to promote increased blood supply and tissue repair.

Should I get PRP for my rotator cuff injury?

The proponents of PRP claim that this intervention allows the body to recover within a shorter period of time compared to routine treatment. Early clinical trials have also shown that PRP can be effective in reducing pain and improving function. However, PRP still remains in its experimental stage, and there are no large-scale studies that have clearly demonstrated its effectiveness and safety. PRP should be considered an experimental procedure that can be chosen if the standard treatment options have already failed.

R3 Stem Cell’s Centers of Excellence offer PRP therapy for shoulder conditions of all types, call us today for top treatment!

References

Barber FA. Platelet-rich plasma for rotator cuff repair. Sports Med Arthrosc. 2013 Dec;21(4):199-205. doi: 10.1097/JSA.0b013e31828a7c6a.

Moraes VY, Lenza M, Tamaoki MJ, Faloppa F, Belloti JC. Platelet-rich therapies for musculoskeletal soft tissue injuries. Cochrane Database Syst Rev. 2014 Apr 29;4:CD010071. doi: 10.1002/14651858.CD010071.pub3.

Scarpone M, Rabago D, Snell E, et al. Effectiveness of Platelet-rich Plasma Injection for Rotator CuffTendinopathy: A Prospective Open-label Study. Glob Adv Health Med. 2013 Mar;2(2):26-31. doi: 10.7453/gahmj.2012.054.

What’s the difference between PRP therapy and stem cell therapy?

In the world of regenerative medicine, both platelet rich plasma therapy and stem cell therapy are now mainstream.
They are both effective and widely used for both degenerative arthritis and soft tissue injuries to tendons and ligaments. However, there is a distinctivprp2e difference between them.

PRP therapy involves utilizing a patient’s own blood from a simple blood draw in the office. The blood is then placed into a centrifuge and spun rapidly for about 15 minutes. The result is a concentrate that includes about seven different growth factors along with a lot of platelets.

In actuality, it does not have many stem cells at all in the final result. It is then injected into the problem area such as the knee, shoulder or hip. Once injected, it does call in the body’s own stem cells for repair, but there’s not a large amount in the PRP itself.

When looking at stem cell therapy, that is the major difference. Bone marrow or adipose derived stem cell treatments contain a large amount of stem cells, along with amniotic derived stem cells as well.

Not only do these materials contain a large amount of stem cells, there are also a considerable amount of growth factors as well. What this does is elevate the healing potential along with doing a lot of the same things that PRP therapy has as well.
Because the stem cell material is more difficult to obtain, there is a significant cost differential in the procedures. While PRP therapy runs between 500 and $1100, stem cell therapy is between $2500 and $5000.

Results with both PRP therapy and stem cell therapy have been exceptional to date in small studies. This includes treatment for degenerative arthritis, rotator cuff tendinitis, if arthritis, spinal arthritis and degenerative disc disease.
There are quite a few physicians who actually administer both treatments together for adjunct of results.

R3 Stem Cell is the nation’s leading clinics for stem cell therapy, call us today to find a center close to you!

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