Call US NOW (844) GET-STEM

Call US NOW (844) GET-STEM


Tag Archive: amniotic stem cell therapy

Does Stem Cell Therapy Work with Bone on Bone Arthritis?

One of the main questions we receive from individuals considering regenerative therapy for an arthritic joint is “Will the stem cell therapy work if I have bone on bone arthritis?” Interstingly, the answer is yes!

We didn’t always think it would help. When R3 first started over five years ago, we told providers it probably wouldn’t work. Thankfully, we were wrong! The outcomes proved to be exceptional over 80% of the time.

As the past five years have gone by and patient after patient has gotten dramatically better from the treatment, we have learned what is most likely happening with the joint treatment.

How Arthritis Occurs

 

Throughout life, people make cartilage at the same rate. It doesn’t matter whether a person is twenty or eighty, cartilage formation occurs consistently. The issue concerns the rate of cartilage loss. Unfortunately, with age comes an increased rate of cartilage loss. So the ratio of formation to loss turns into a mismatch.

This leads to an overall loss and degenerative arthritis. What’s being accomplished with a regenerative procedure (e.g. umbilical cord stem cell therapy), is putting the ratio back into the patient’s favor. It is NOT a cure or a complete fix, anyone who says that is not being realistic.

With the ratio being put back into the patient’s favor, cartilage formation can accumulate in a joint. Often times, noticeable joint improvement will occur on x-rays over time. It does not need to be a ton, simply a couple millimeters will usually be enough to create tremendous relief for patients.

How long will the relief last from a regenerative injection?

 

This is variable, and there is no set time frame. We have seen patients treated five years ago doing fantastic, while others may need a repeat treatment after a couple years. A person may not need another stem cell treatment, but may just benefit from a PRP treatment. The relief usually starts within the first month, and continues to improve for over six months.

There is no age limit to the treatment. R3’s Centers have seen patients upwards of age 102. The desire may simply be to walk farther, play more with the grandkids or play golf more often. Thankfully, the treatments are extremely safe in addition to being effective over 80% of the time.

How is Amniotic and Umbilical Cord Tissue Regulated?

 

Amniotic and umbilical cord tissue is strictly FDA regulated. During processing, any DNA factors are removed so it does not lead to rejection. The best labs, such as the ones R3 works with, ensure very high cell viability by not using radiation and only minimal preservative. This is one reason the outcomes at our Centers has been so amazing.

With the outcomes being so exceptional, over 95% of patients considering treatment at R3 now ask for amniotic and umbilical cord tissue treatment. Along with the outcomes, there is no need for harvesting so the potential for chronic donor site pain is avoided. When a bone marrow or adipose procedure is undergone, the potential for chronic donor site pain is over 30%, and with each year that goes by the regenerative cell counts in the human body decreases considerably.

 

R3 Stem Cell has over thirty Centers of Excellence nationwide. All of them offer a free consultation, and the providers are first rate. Call today to set up your visit to R3, where Regenerative Medicine is Made Easy!

Amniotic Stem Cell Therapy for Diabetic and Peripheral Neuropathy

 
Amniotic Stem Cell Therapy for
Diabetic and Peripheral Neuropathy

By David Greene MD, MBA
Neuropathic Pain
Diabetic and Peripheral Neuropathy pain affect 6% of the population.
70% of diabetics suffer from neuropathy.
Pain is sharp, burning, lancinating, electric.
Not just pain, the decreased sensation affects walking ability.
Neuropathy Traditional 
Treatment Options
Opioids and NSAIDs
Oral and Topical
Questionable Benefit
Off label tricyclic antidepressants, anticonvulsants.
Neurontin, Lyrica
TENS unit
Only 30% achieve adequate relief with these methods.
Neuropathy Traditional 
Treatment Options
Spinal Cord Stimulator Implant
Revolutionary for relief and sensation return.
Over 80% pain relief.
85% improved sensation, 58% sensory deficits reversed completely.
Regenerative Medicine
The NEW paradigm, a nonoperative treatment that can actually repair damaged tissue. Provides pain relief and improved sensation.
Low risk, outpatient, effective – isn’t that what medicine has been looking for?
Consider this:
20 years ago plastic surgery was 90% operative. Now it’s 90% nonoperative!
Regenerative Options for
Diabetic and Peripheral Neuropathy
PRP Therapy
Blood draw, spun in centrifuge concentrates platelets/growth factors.
Bone Marrow
Adipose (fat)
The newest – Amniotic
Not really new
Used for decades
Amniotic Stem Cell Therapy
Remarkable addition to regenerative medicine.
Obtained from consenting donors after scheduled c-section.
FDA Regulated (CGTP)
AATB Certified
Cryogenically Frozen
No embryonic cells or fetal involvement
Amniotic Qualities
Immunologically Privileged
No Rejection Reaction
Growth Factors
Hyaluronic Acid
Stem Cells and Activators
Antimicrobial
NONsteroidal
Protocol
Amniotic stays on dry ice or in cryogenic freezer until ready to use.
Thaw for 10 minutes.
Usually 1-2 cc’s per limb, ok to dilute 3:1 with sterile water/saline/lidocaine.
Procedure takes less than a half hour.
Outcomes
We know that mesenchymal stem cells in animals significantly reduce neuropathic pain.
A preliminary report on stem cell therapy for neuropathic pain in humans – J Pain Res 2014
10 pts, In this preliminary proof-of-concept study, the administration of a mixed population of adipose-derived cells, including MSCs, was shown to be able to attenuate orofacial neuropathic pain symptoms in a diverse range of patients considering variables of age and the established duration of the pain state.

Outcomes
Anti-Inflammatory Mesenchymal Stem Cells (MSC2) Attenuate Symptoms of Painful Diabetic Peripheral Neuropathy 2012 Stem Cells Transl Med.
Over 40% inflammatory and pain reduction in mice.
Related to their capacity to not only control pain as a symptom, but to modulate the neuroimmune component which plays a relevant role in neuropathic pain.

Risks
Risks have been absolutely minimal.
Have not seen rejection
NO steroid.
It’s antimicrobial so risk of infection has been minimal.
Coverage
Currently amniotic stem cell therapy for neuropathy is an out of pocket expense.
Insurance will cover the visits, imaging, lab work but NOT the amniotic material.
New technology takes a while to capture reimbursement.
Bottom Line
Amniotic therapy works in preclinical studies and in early human pilot studies.
It is low risk, potential high benefit, and has live cells depending on processing.
No embryonic stem cells or fetal involvement!
Can help you and your loved ones avoid surgery and achieve relief and walk better.
R3 Stem Cell
R3 partners with top providers nationwide to offer regenerative treatments for all types of musculoskeletal conditions – knee, hip, shoulder, ankle, elbow, wrist, etc.
This includes back and neck conditions as well as neuropathy.
Visit us at R3StemCell.com and call us to find a treatment center at (844) GET-STEM.

Stem Cell Therapy on the Cutting Edge for Musculoskeletal Problems

Although stem cell therapy is still considered to be in its infancy, it has proven to be a useful and powerful tool in helping to improve, repair, and augment the healing of various musculoskeletal problems. Health issues associated with the musculoskeletal system, which includes our muscles, cartilage, tendons, ligaments, joints, and various other connective tissues, can be extremely taxing.

The musculoskeletal system supports and binds tissues and organs together, allowing us to perform a stem cellswide range of physical activity. When one single aspect of the system is compromised it can result in hampered movement and mobility, ongoing pain, and diminished quality of life. Many of the common remedies associated with injuries and illnesses that affect the system involve a combination of drug therapies and surgical procedures.

Thus, the hope that stem cell therapy has given those suffering with such problems and the results that have been observed and experienced have helped to improve the quality of life for many, while creating optimism for the future. We are on the cutting edge of a new way of dealing with and solving musculoskeletal problems.

Common Uses Today

There are various injuries and maladies for which stem cells are used today. Commonly the stem cells are injected into the area to be treated. Once they have been injected into the damaged area, they begin working to aid in the repair of it. This may include:

  • Amniotic Derived Stem Cells
  • Bone Marrow Derived Stem Cells
  • Adipose (Fat) Derived Stem Cells

Stem cells have been found to be effective in treating joint problems and various disorders, including arthritis, regions where cartilage and ligament damage has been experienced, and bone injuries. There’s also a lot of hope for the future use of stem cells in a wide range of situations, including heart disease, Parkinson’s disease, diabetes mellitus, amyotrophic lateral sclerosis, spinal cord injuries, and burn treatments.

The Power of Stem Cells

Stem cells derive their power from the fact that they are versatile, having the potential to differentiate into a wide range of cell types. This makes them highly adaptable, as they can adjust to help muscles, cartilage, tendons, ligaments, and bones heal. Additionally, they have been shown to possess the power to reduce inflammation and enable healing, so that tissues grow more quickly.

The treatment itself is minimally invasive, usually involving an injection in the area to be treated. It is also considered to be a low risk type of therapy. For many, the use of stem cells is certainly preferred Stem Cell Therapy for Plantar Fasciitisto more invasive surgeries that involve protracted periods of recuperation and rehabilitation.

Are You Candidate for Stem Cell Therapy?

If you have muscle, cartilage, tendon, ligament, joint, or bone injuries or damage, then you may be a good candidate for stem cell therapy. In practicing osteopathic medicine, many doctors now offer patients a range of treatments that include stem cell therapy, rehabilitation, drug treatments, and/or surgery. With more choices, and the opportunity to try something like stem cell treatment, which is less invasive, considered to be relatively risk free, and results driven, patients have the opportunity to experience the newest medical techniques.

If you or a loved one is suffering from degenerative arthritis, sports injuries, ligament or tendon injury, call or email us today to find a location close to you for treatment – (844) GET-STEM!

Stem Cells Derived from Amniotic Fluid: New Potentials in Regenerative Medicine

Human amniotic cells have been used over the past 50 years as a diagnostic tool for prenatal diagnosis of genetic abnormalities in the fetus. Over the past 5 years, however, the potential for using stem cells derived from amniotic fluid has become a reality, especially for treating chronic diseases and conditions.

Stem Cells for Rotator Cuff Tears

Amniotic fluid derived stem cell therapy works well for rotator cuff tears

Amniotic derived stem cells can be harvested from the amniotic sac of a pregnant female. This occurs during child birth or during a procedure called amniocentesis. Since amniocentesis has slight risks, the most common scenario is that amniotic fluid  is obtained during a caesarean section from a consenting donor.

Otherwise it would be discarded, and thankfully amniotic fluid contains a very high concentration of stem cells.

These cells are prized for their ability to form a variety of differentiated cell lines such as blood, bone, muscle, liver, skin, and more. This is unlike the other types of stem cells (other than embryonic), which are only able to differentiate into certain types of tissues.

The Focus

The focus for using stem cells derived from amniotic fluid comes from the ethical battle fought over using embryonic stem cells. Many activists do not like the idea of using stem cells derived from fetuses. Instead, using stem cells derived from amniotic fluid solves this ethical issue. The mother can bank her amniotic fluid or the umbilical cord (which is also rich with stem cells) for later use.

The amniotic fluid found in the womb promotes the develop of the fetus. It is inhaled and exhaled by the fetus in the womb and directly responsible for the development of the lungs. The amniotic fluid promotes the development of the limbs, and passes through the body of the developing fetus re-entering the womb as urine.

How are Stem Cells Derived from Amniotic Fluid used in Research?

Amniotic Stem Cell TherapyThe amniotic cells used in research are primarily donated by mothers in their first trimester of pregnancy. Amniotic derived stem cells were found to have similar properties to embryonic stem cells after tests were performed.

Researchers found that the cells were grown and reprogrammed into a more primitive state when valproic acid was added to the culture medium. Tests run on these cells showed that amniotic derived stem cells have the capability to develop into any type of cell found in the body with a property called pluripotency.

The potential of using amniotic fluid to cure all kinds of diseases, disorders, and injuries is now a reality. Amniotic stem cells not only offer a rich cell line to assist in research but also seem to offer a customized cell supply for newborns and sometimes their siblings. These cells are the medium between embryonic stem cells and adult stem cell lines, such as bone marrow derived stem cells.

Research and the Future of Stem Cells

In the research arena, stem cells are grown in a culture, and there is potential for reengineering and regenerating cells and tissues. Some research has shown that amniotic derived stem cells differentiate using a scaffold or three-dimensional matrix for support.

These cells have been documented to have the ability to differentiate into all types of cells and tissues with a high renewal capacity and no loss of cellular integrity. Stem Cell therapy

The positives outweigh any thought of a negative aspect to using amniotic derived stem cells for treatment and therapy. It is believed that about 38 percent of the population could be treated as a match from stem cells harvested from about 150 donors. This is amazing statistics when you consider the closest approved therapy right now is bone marrow implantation, as well as the odds of finding a donor and the risk of rejection.

R3 Stem Cell offers amniotic stem cell therapy for numerous musculoskeletal conditions including plantar fasciitis, degenerative arthritis, rotator cuff and achilles tendonitis, ligament injury and more. Amniotic derived stem cell therapy offers nonoperative pain relief with the potential to regenerate damaged tissue!

How does Amniotic Stem Cell Therapy Work for Rotator Cuff and Achilles Tendonitis?

Amniotic stem cell therapy is one of the most effective forms of treatment for many different conditions present within the tendons and joints. The amniotic tissue is contained within the uterus, and its main specialized duty if to offer regenerative healing properties to the fetus while in the mother’s womb.

There is a high amount of stem cells present in amniotic fluid, which makes it easy for the cells to be obtained and used for treatment. While the uses of amniotic stem cell therapy is still being researched, and additional treatment options are presenting themselves, this type of therapy is growing in popularity for conditions such as rotator cuff tendonitis, Achilles tendonitis, and other similar issues.

Amniotic Stem Cell Therapy

The rotator cuff is a structure within the body that works to support the shoulder, and offers significant stability. The cuff is made from a variety of tendons, which work together to create the support. When one of the tendons becomes damaged due to excessive use, trauma, or another issue with the area, the condition is known as tendonitis of the rotator cuff. Surgical procedures do not always help the condition, and could actually cause it to become worse in some cases.

When amniotic stem cell therapy is used for issues with the rotator cuff, there are a few different ways in which the therapy works. For one, when there is an issue present with the tendon, the area will become inflamed, which can lead to pain, swelling, and joint immobility, and even the possibility of more damage occurring. The stem cells derived from the amniotic tissue have shown to help the area repair by providing it with anti-inflammatory effects, growth factors and stem cells. This will decrease the amount of pain present and also take pressure off of the damaged tendon.

Other than taking away inflammation in the area, the amniotic stem cells work to help the tendon to regenerate. The tendon will experience healing in the form of thickening of the tissue within the tendon and regeneration of the structure where damage has occurred. The hyaluronic acid in the amniotic stem cell material also provide lubrication to the tendon, which will prevent further damage from occurring in the area while healing takes place.

The Achilles tendon is the largest tendon in the body, and it goes from the area of the heel, to the top of the calf. When stem cell therapy is used for this area, the healing action is done in the same manner as for the conditions with the tendon in the rotator cuff. While inflammation is sometimes seen with damage in the shoulder area, inflammation is the most common issue to occur when the Achilles tendon becomes damaged. The stem cells offer relief from inflammation, while also providing the area with the ability to repair itself.

How Amniotic Stem Cell Therapy is Provided

Amniotic stem cell therapy is done through the use of injections, which are made directly into the tendon, and they may also be made to the surrounding area. Once the injection is made, pain relief is often provided right away due to the anti-inflammatory properties, and healing will occur at a fast rate as well. However, the rate can differ between patients due to age, the amount of damage present, and the body’s response to the therapy.

R3 Stem Cell Clinics offer first rate, Board Certified doctors who are highly skilled in stem cell therapy. If you or a loved one is suffering from pain in the shoulder, heel, achilles and other areas, stem cell injections  with amniotic fluid derived treatment may help. Call an R3 stem cell clinic today!

Join Email List

×