World-Class USA Stem Cell Therapy, Now Available in Istanbul! Get in touch today for a personalized consultation.
Regenerative stem cell and exosome therapy in Istanbul, delivered by R3 International — the same US-based clinical group that has performed more than 29,000 procedures across 8 countries over the past 12 years. Treatment starts at $3,999 for 25 million cells.

R3 International runs a stem cell clinic in Istanbul that treats patients from Turkey, Europe, and the Middle East — with cells cultured to American quality standards.

Umbilical cord MSCs from Wharton's jelly
The cells we use are mesenchymal stem cells (MSCs) taken from umbilical cord tissue, specifically Wharton’s jelly, and they are processed in our own FDA-regulated laboratory in the United States under a Mayo Clinic-trained PhD.
That lab is the part most clinics can’t match. The MSCs and exosomes are cultured to US quality standards and then used in Istanbul, so you get the biologics of an American program at Turkish pricing.
Depending on your condition, cells can be given several ways: intravenous (IV) infusion, intrathecal injection, direct joint injection, nebulizer, or intranasal. Protocols range from 25 million cells up to one billion, and every protocol is built around one patient rather than a fixed package.
The same cultured cell dose costs less than half what it does in the US. What matters more than the country is where the cells are cultured.
Less than half the US cost
The identical quantity of cultured MSCs costs less than half in Istanbul what it would in the United States — without cutting lab standards.
Scale without compromise
End-to-end travel care
Half are repeat or referred
Watch our YouTube playlist featuring patient journeys, clinic walkthroughs, and regenerative medicine insights from the R3 team.
We group conditions by how well the research supports stem cell therapy, because you deserve a straight answer about what the evidence actually shows.
This is where stem cell therapy has the strongest clinical support. MSC injections are studied for their ability to reduce inflammation in joints and support cartilage and soft-tissue repair, and many patients use them to avoid or delay surgery.

These are areas of active research. The science is promising and patients ask about them constantly, but the evidence is still developing, and stem cell therapy for these conditions is experimental. We don't promise cures. What we offer is a customized protocol, an honest conversation about what's known, and a program with a strong safety record.

R3 offers stem cell and exosome therapy by injection, IV, intrathecal, nebulizer, and intranasal delivery, for more than 50 conditions. Alongside MSCs, protocols can include exosomes, PRP, peptides, and vitamin therapy. All procedures are nonsteroidal and outpatient.
Four steps, start to finish:
A regenerative specialist reviews your history by phone or video and tells you honestly whether you're a candidate.
Once your protocol is set, our team books flights, accommodation, and transport.
Your procedure is performed at our clinic by experienced providers. Many treatments are same-day.
We arrange your trip home and stay in contact through recovery.
Every therapy at R3 is designed to work with your body’s own repair mechanisms rather than against them. In over a decade of procedures, R3 has not recorded a significant adverse event. Individual results vary, and only your own physician can weigh the risks and benefits for your situation.
R3 Stem Cell was founded by David Green and operates Centers of Excellence in more than 80+ locations. Our Istanbul biologics come from a US laboratory run by a Mayo Clinic-trained PhD.
Whitney is the best!!!! Have seen her for Botox and filler and I will never go anywhere else!
I was referred here by a friend as I am getting more wrinkles as I get older. I consistently get my microneedling and Botox done here and I am constantly... I was referred here by a friend as I am getting more wrinkles as I get older. I consistently get my microneedling and Botox done here and I am constantly impressed.
Read moreI was looking for a reputable medspa to help with my skin texture and acne and decided to go to R3. Best decision! I got the PRP microneedling here and... I was looking for a reputable medspa to help with my skin texture and acne and decided to go to R3. Best decision! I got the PRP microneedling here and I got amazing results.
Read moreThis is a fantastic place. I highly recommend it to anyone looking for great service.
Stem cell treatment at R3 International starts at $3,999 for 25 million live cells, given by IV or as an injection into two joints in one session. Multi-treatment packages and regenerative cosmetic procedures are available, and consultations are free.

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FREE DOWNLOADAt R3 International in Istanbul, treatment starts at $3,999 for 25 million live cells, given by IV or injected into up to two joints in one session. Protocols scale from 25 million up to one billion cells, so your condition drives the cost. Consultations are free.
Turkey works well on cost and access. Istanbul has direct flights from most of Europe and the Middle East, and the same cultured cell dose costs less than half what it does in the US. What matters more than the country is where the cells are cultured.
There's no single best country. Judge the lab, not the location. Ask any clinic about cell source, culture standards, dose measured in live cells, and adverse event history. R3 cultures its biologics in an FDA-regulated US laboratory and administers them in Istanbul at Turkish pricing.
It's legal but tightly regulated. Turkey's Ministry of Health oversees cell-based products, TİTCK licenses tissue and cell centres, and treatment must take place at authorised human application centres. Cultured cell therapies are classed as advanced therapy products, not approved cures. Ask any clinic to show its authorisation.
Mesenchymal stem cells from umbilical cord tissue, specifically Wharton's jelly. Cords are donated after healthy full-term births with consent, so nothing comes from an embryo or fetus. The cells are cultured in our own US laboratory under a Mayo Clinic-trained PhD.
Most patients tolerate it well. IV infusions feel like any drip. Joint injections are done under local anaesthetic and leave soreness for a few days. Everything is outpatient and nonsteroidal, so there's no surgical recovery. Intrathecal delivery involves a lumbar puncture.
Many treatments are same day, and for straightforward joint or IV protocols we offer a there-and-back option. Intrathecal and multi-dose protocols need longer. We arrange airport pickup and ground transport either way, and your specialist confirms the timing once your protocol is set.
No. In the United States stem cell therapy is regulated by the FDA but not approved for the conditions we work with, and R3 does not offer it as a cure. Our US laboratory operates under FDA regulation. That covers the lab, not the therapy.
It varies, and anyone giving you a firm date is guessing. Joint patients often report change over four to twelve weeks as inflammation settles. Neurological and systemic conditions are less predictable. Some patients see no benefit, which is why we follow up rather than disappear.
Across more than 29,000 procedures in twelve years, R3 has not recorded a significant adverse event. That's a track record, not a guarantee. Any injection carries risk of infection, bleeding, and short-term reaction. Only your own physician can weigh those against your situation.
Active cancer, current infection, pregnancy, and some blood or clotting conditions usually rule treatment out. Certain medications matter too. The free consultation exists partly to say no. If we don't think you'll benefit, we'll tell you instead of booking you.
Book a free phone or video consultation to find out whether you or a loved one is a candidate. Call +90 850 390 1805 (US:) (844) GET-STEM) or request a callback.