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Tag Archive: amniotic stem cells

Do Amniotic Stem Cells Work?

amniotic fluid stem cells pros and cons Amniotic stem cells are a mixture of stem cells that can be extracted from the amniotic fluid and amniotic membrane after a pregnant woman has delivered her baby. The amniotic fluid surrounds the fetus during development in the uterus and it is contained by the amniotic membrane.

Since the amniotic fluid and amniotic membrane are collected after the baby is delivered, as they have usually been discarded in the past, there is no danger to the child when doing so. Therefore, the use of stem cells derived from amniotic tissues is considered to lack the ethical problems associated with the use of stem cells derived from embryos collected after induced abortions.

Stem cells that are derived from tissues such as the amniotic fluid and amniotic membrane, as well as those from the bone marrow, are used in medicine for the following reasons:

  • To help stimulate proteins to reduce the inflammatory process in certain conditions that lead to pain, tissue damage, and disability.
  • Differentiating and developing into tissues of the body such as skin, muscle, cartilage, bone, nerve, and heart and kidney tissue to repair areas damaged by diseases and injuries.

Advantages and disadvantages of amniotic stem cells

Amniotic stem cell pros and cons need to be looked at in order to decide whether using such tissue has benefits that outweigh any risks associated with its administration.


  • The amniotic fluid contains an abundance of mesenchymal stem cells (MSCs) that stem from the fetus.
  • These MSCs have a higher expansion potential than the ones derived from the bone marrow which means that more new tissue cells can be derived from the amniotic fluid.
  • These stem cells have an enhanced stability and plasticity compared to adult stem cells allowing them to develop into healthier cells needed for tissue repair.
  • Amniotic stem cells can be used to reconstruct birth defects such as diaphragmatic hernias in children, as well as repairing a premature amniotic membrane rupture during pregnancy.
  • There’s no risk of the patient rejecting the stem cells.
  • The amniotic stem cells contain hyaluronic acid that helps to lubricate the cartilage around joints.


  • Amniotic fluid doesn’t contain a lot of embryonic stem cells.
  • If there are pathologies that need to be treated while the mother is still pregnant with the fetus, then an amniocentesis needs to be performed. This is a technique where a needle is inserted into the uterus through the amniotic membrane and amniotic fluid is then collected. This does carry a small risk of causing a spontaneous miscarriage or premature labor.


In one literature review study regarding the most recent progress in stem cell therapies and indications in the specialty of orthopedics, the following observations were made:1

  • Stem cell therapy has been successfully used for managing major orthopedic issues such as bone-joint injuries, ligament-tendon injuries, osteoarthritis-cartilage defects, and femoral head osteonecrosis.
  • Stem cells have been used in bone tissue engineering and were combined with scaffolds to provide better and faster tissue healing.
  • A recommendation was made that more and efficient studies would need to be conducted to evaluate the safety of stem cells.

With that being said, the general consensus looking at patient outcomes is that stem cell therapy is a very safe and effective form of treatment.

Amniotic Stem Cell Therapy for Wound Healing

Over the past five years more and more proof has come to light concerning amniotic stem cell therapy and its use in promoting wound healing. The use of stem cells harvested from amniotic fluid is having a major effect in the area of regenerative medicine. These cells increase the development of blood vessels that are a necessary part of the healing process. Such vessels do two things, they carry blood to the site of new tissue and they carry waste away from the site, thus promoting faster wound healing.

Recent Success

There have been various studies and reports developed over the years concerning amniotic stem cell Stem Cell Therapy for Wound Healingtherapy for wound healing. A recent report regarding efforts by scientists at Rice University and Texas Children’s Hospital offer evidence regarding the efficacy of this type of stem cell therapy.

Bioengineer Jeffrey Jacot, who is deeply involved in a project focusing on the use of these cells, described a breakthrough, noting, “The main thing we’ve figured out is how to get a vascularized device: laboratory-grown tissue that is made entirely from amniotic fluid cells. We showed it’s possible to use only cells derived from amniotic fluid.”

The Power of these Cells

Amniotic cells are powerful due to the fact that they are versatile. This versatility makes them invaluable. These cells are able to differentiate into many other types of cells, including endothelial cells. Endothelial cells form blood vessels and the formation of such vessels is essential in augmenting the healing process.

In helping to form blood vessels, amniotic stem cells create an environment that promotes wound healing. In essence, they enhance the pathways that bring much needed nourishing nutrients and other substances found in blood and this improves healing. At the same time, they carry away waste, allowing for greater efficiency and shortening healing time.

Recent Experiments

In a recent trial at Rice University and Texas Children’s Hospital, a hydrogel, which was seeded with amniotic fluid stem cells, revealed growth of mature blood vessels just two weeks after being established. The use of a hydrogel in the process is important, as this substance, which is composed of a network of polymer chains that are highly absorbent, acts as a scaffold in tissue engineering. A hydrogel allows amniotic stem cells to become established, enabling them to begin the process of tissue repair.

Basic Wound Healing

The experiments at Rice University and Texas Children’s Hospital are an advancement in therapy that has existed for years. The fact is the injection of amniotic stem cell therapy for wound healing has been successfully done thousands upon thousands of times. Types of wounds on which these cells have been used successfully include difficult wounds that are slow to heal, such as those in diabetics. Other types of wounds that have benefited from these injections are those associated with plastic Stem Cell therapysurgery and instances in ophthalmologic treatment where corneal injury has occurred.

Safe Therapy

Along with evidence that amniotic stem cell therapy for wound healing is an effective way to promote cell growth is the fact that in its thousands of uses there is no evidence of any adverse events or effects. Thus, this type of therapy offers a solution for those with slow healing wounds that is safe as well as effective.

R3 Stem Cell offers Centers of Excellence that provide amniotic stem cell therapy for wound healing. The treatments have an exceptional success rate for healing chronic wounds such as those from venous stasis and diabetes. This includes post-operative as well.

If you or a loved one is suffering from a non-healing wound, call (844) GET-STEM today for the best stem cell therapy for wound healing!

FAQs on Amniotic Stem Cell Therapy

What are amniotic stem cells?

Amniotic stem cells are extracted from the amniotic fluid via a process called amniocentesis or after a c-section from a consenting donor. This procedure allows the harvest of stem cells without harming the embryo, although there is a small risk of pregnancy loss during or following the procedure. The sparing of the embryo makes the harvest of amniotic stem cells more acceptable than embryonic stem cells.

Stem Cell InjectionsBy harvesting the amniotic fluid after the c-section, there is no risk of pregnancy loss.

Amniotic stem cells are pluripotent stem cells that are derived from the mesenchyme. Being pluripotential, these stem cells can differentiate into a wide variety of cell types, including nerves, bone, cardiac muscle fibers, skin and cartilage.

There has been an increase in funding for research on the use of amniotic stem cells for organ regeneration. It is now possible to store stem cells in private stem cell banks, and there has been significant growth in the stem cell industry.

How are stem cells used for treatment?

Stem cell therapy has been approved for very few conditions. Some studies have found that stem cell therapy is effective for immunological and hematological conditions.

There is research that shows amniotic stem cells have promising use in regenerative medicine. As these cells can grow into muscle, cartilage and other forms of tissue, therapies to inject stem cells to stimulate growth and healing are currently being assessed. Cell transplantation technology is currently being developed, and amniotic stem cells appear to be at the forefront of this field.  Stem cells have also been marketed as anti-aging therapy, although research on this particular area has been limited.

Stem cells have been shown to provide promising outcomes in their therapeutic use for progressive and degenerative conditions such as arthritis, tendonitis, and poor-healing wounds. Movement disorders have also been shown to respond to stem cell therapy. It is theorized that these effects are secondary to the increased levels of cell growth and healing factors that accompany stem cell therapy. There are also attempts to use amniotic stem cells for tissue engineering, and for the development of organ transplants.

What are the outcomes for amniotic stem cell injections?

The effectiveness of stem cells as a therapeutic option varies, and more research still needs to be conducted before definitive endorsement of amniotic stem cell therapy can be made. However, this intervention has been shown to provide good outcomes in smaller studies and case reports.Stem Cells for Knee Arthritis

Stem cell injection has been shown to be a well-tolerated procedure that is generally safe. The injection of amniotic stem cells is a minor outpatient procedure that allows a patient to be discharged within the same day.

It should be noted that adverse outcomes are fairly rare with stem cell injection. It also is important to differentiate the actual clinical improvements noted by your physician from any possible placebo effect(s).

Amniotic stem cell injections for musculoskeletal conditions has been increasing in popularity for a number of reasons. The most common reason is because the material is showing excellent results in small studies for arthritis, tendonitis and ligament injury.

Also, amniotic stem cell materials also contain a significant amount of hyaluronic acid along with anti-inflammatory factors. It’s part of what makes amniotic fluid so exciting is the multitude of ingredients!

If you are suffering from pain in the shoulder, hips, knees or ankles, it may be due to arthritis, tendonitis or a ligament injury. Amniotic stem cell therapy may help you with pain relief to avoid surgery and get you back to activities you want!

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Abdulrazzak H, De Coppi P, Guillot PV. Therapeutic potential of amniotic fluid stem cells. Curr Stem Cell Res Ther. 2013 Mar;8(2):117-24.

Ge X, Wang IN, Toma I, et al. Human amniotic mesenchymal stem cell-derived induced pluripotent stem cells may generate a universal source of cardiac cells. Stem Cells Dev. 2012 Oct 10;21(15):2798-808. doi: 10.1089/scd.2011.0435.

Petsche Connell J, Camci-Unal G, Khademhosseini A, Jacot JG. Amniotic fluid-derived stem cells for cardiovascular tissue engineering applications. Tissue Eng Part B Rev. 2013 Aug;19(4):368-79. doi: 10.1089/ten.TEB.2012.0561.

Rodrigues MT, Lee SJ, Gomes ME, Reis RL, Atala A, Yoo JJ. Amniotic fluid-derived stem cells as a cell source for bone tissue engineering. Tissue Eng Part A. 2012 Dec;18(23-24):2518-27. doi: 10.1089/ten.tea.2011.0672.

Saito S, Lin YC, Murayama Y, Hashimoto K, Yokoyama KK. Human amnion-derived cells as a reliable source of stem cells. Curr Mol Med. 2012 Dec;12(10):1340-9.

Amniotic Stem Cell Injections for Foot and Ankle Problems

Stem Cells for FootAmniotic stem cells are considered to be undifferentiated or multipotent cells. They have the ability to differentiate into many lineages of cells. These lineages include skin, bone, blood, muscle, and liver cells. The possibility of using amniotic derived stem cells to heal foot and ankle problems is a two-fold solution.

A major health problem faced by patients with diabetes or other diseases causes foot wounds or leg ulcers that can be difficult to cure. With the use of amniotic derived stem cells, patients suffering from these conditions will actually see a cure from something that was previously incurable.

How Do Amniotic Stem Cell Injections Work?

To understand the mechanism of how amniotic stem cell injections work, we must first take a step back and look at how they are harvested and processed then added back into the body. Amniotic stem cells can be harvested through the collection of amniotic fluid during the birth of a child.

Amniotic stem cells are derived from the amniotic fluid and tissues that are found in the womb of a pregnant woman. The fluid is obtained during scheduled c-sections. Normally it would be discarded after the birth.

Once the fluid is collected, the stem cells are filtered out and processed. They can then be added back into the body. With Stem Cells for achillesamniotic derived stem cells, they have the ability to differentiate into many different types of cells.

The stem cells are injected into the afflicted area. There have been many successful cases where tissues have grown back from previously incurable conditions. The treatment of ulcers and wounds to the ankle and foot often do well with an injection of the stem cells, a specialized kind of tissue to be placed over the wound, and debridement before the stem cells are injected.

The amniotic stem cell therapy can help patients avoid surgery and obtain pain relief with achilles tendonitis, ankle arthritis, difficult to heal wounds, plantar fasciitis and more.

The results of this treatment are amazing. In most cases, within two weeks there is a marked improvement in skin condition. There is improvement and complete healing seen in cases where extreme wound conditions were previously seen such as in limb salvage.

Uses of Amniotic Stem Cells

Amniotic stem cells are also used to add in the repair of bone fractures, arthritis, and other conditions affecting the foot and ankle. The treatment is performed in the same manner, with the injection in the afflicted area. For cases where there is a severe break, the injection will occur over a period of time. In cases where arthritis is treated, one injection is given, and then, another follows several weeks later to treat the cause of the inflammation and to give relief from the pain. Stem Cells for plantar fasciitis

The difference in stem cell treatment versus the traditional treatment with cortisone shots is that stem cell therapy treats the root cause of the condition, seeking to change the course of the condition and create healing. Cortisone shots only lessen the pain and do not have the ability to change the course of the actual condition.


Amniotic stem cell injections are still being studied in their effectiveness to treat foot and ankle conditions. Clinical studies have shown marked improvement in patients suffering from wounds caused by conditions such as diabetes. Fractures and other injuries show promise in stem cell treatment as well with therapy occurring on a weekly or bi-monthly basis.

R3 Stem Cell works with foot and ankle specialists nationwide. The treatment works extremely well and is administered as part of numerous research studies. Visit the site today to find a clinic close to you for stem cell therapy for your foot or ankle problem!

Stem Cell Therapy for Plantar Fasciitis

Uses for Amniotic Derived Stem Cell Injections

If you have ever had a baby, you probably received unsolicited mail advertising services for banking amniotic stem cells. Since 2009, when the first stem cell bank opened in Medford, MA, cryopreservation and private banking of amniotic fluid stem cells has slowly grown in popularity. For those who are not familiar with amniotic stem cells, they are stem cells derived from the mesenchyme and extracted from the amniotic fluid.

Amniotic stem cells are considered to be a medical miracle, because they can differentiate into a variety of tissue types including bone, muscle, cartilage, skin, nerves, and cardiac tissue. The potential use of these cells gives hope for organ regeneration and recovery from paralysis.

Amniotic stem cells are obtained during a scheduled c-section from consenting donors. Otherwise the fluid is simply discarded – so why not use it for medical benefit? The fluid is processed at an FDA regulated lab prior to usage in individuals that need it.

Why Use Stem Cells?

Amniotic stem cells are a better choice in technologically advanced medical procedures because they do not harm the fetus or the use of an embryo. There is no risk of procedure-related pregnancy loss since the fluid is obtained after birth and not from an amniocentesis. Studies on amniotic fluid have found it rich in epithelial, neural, endothelial, hematopoietic, and mesenchymal stem cells.

Scientists and researchers have genetically engineered liver cells, neural cells, fat cells, heart cells, bone cells, working tracheas, and artificial heart valves by using amniotic stem cells. This indicates that the use of amniotic stem cells in treating a multitude of medical conditions previously thought to be life threatening or untreatable.

Examples of Amniotic Derived Stem Cell Use

Stem cell therapy is a type of intervention therapy which introduces stem cells into damaged tissues to treat an injury or disease. In the world of pain management and orthopedics, stem cell therapy is being used for numerous conditions such as degenerative arthritis, tendonitis, ligament injury and more.

It also works well for wounds that are having difficulty healing, such as in diabetics.

Future Clinical Uses of Amniotic Stem Cells

When it comes to using amniotic stem cells, the uses continue to grow. What is really needed are larger clinical studies. Small studies have shown excellent results so far for regenerative stem cell treatments for musculoskeletal conditions.

Several clinical trials have emerged where subjects are treated with their own stem cell derived bone marrow, and others involve healthy athletes who are treated for osteoskeletal injuries to the bones, joints, or connective tissues. While these treatments have not entered mainstream medical practice, the potential is there for major breakthroughs.

A plethora of athletes have received stem cell therapy and PRP therapy for sports injuries. And the number continues to grow. R3 offers stem cell clinics nationwide with treatments for all types of musculoskeletal injury. Find one close to you today!

Why is Amniotic Tissue Great for Regenerative Medicine?

Regenerative medicine is a relatively new and rapidly evolving field in the treatment of pain management, chronic disease, and injuries previously treatable with only surgery. Stem cell therapy has gained the attention of the scientific community over the past few decades, first with investigational research using embryonic stem cells and now with research focusing on amniotic tissue and amniotic fluid. The stem cells harvested from amniotic derived media are multipotent and able to differentiate themselves into a variety of tissue types. They are characterized by the ability to renew themselves through cell division and the potential to treat many previously untreatable conditions.

The Amniotic Membrane

The majority of research focuses on amniotic fluid and the stem cells that are harvested from this fluid. We must not forget about the stem cell rich amniotic membrane as well. The human amniotic membrane is made up of two types of stem cells: human amnion mesenchymal stromal cells and human amnion epithelial cells. Both of these types of cells display the same properties. When studied in vitro, they differentiate into mesodermal lineages.

The human amniotic membrane has also been used in plastic surgery for the treatment of wounds and corneal problems and in ophthalmology. In recent studies using human amniotic membranes, the tissue patch was successful in helping heal major leg wounds on a dog and to reduce scar adhesion and fibrosis at the site of surgery.

Interventional Pain Management

Human amniotic membranes are also at the forefront of interventional pain management. Using amniotic tissue to treat pain management is actually treating the root cause and not the symptoms, as most other treatments do. Studies concentrating on pain management therapy are investigating the role of amniotic tissue in the healing of tissue damage and inflammation.

One of the more successful studies involved injections of amniotic epithelial cells into an equine digital flexor tendon defect. The result was the growth of new collagen fibers to aid in the repair of that area. The stem cells acted as an activator to the injured or defective area so that growth factors are released and trigger collagen production, aiding in the healing process. Other studies have concentrated on injections of amniotic epithelial cells into the defective Achilles tendon of a sheep. The result was promotion of structural and mechanical recoveries during the early phase of healing.

Future Applications

The primary challenge right now is establishing an efficient method to generate amniotic cell cultures, eliminating the need for refrigeration and centrifugation of fresh samples. This would allow for a continuous supply of clonal lines from amniocentesis samples and birth harvests. Communication is another issue that amniotic derived tissue can solve. In studies where bone marrow derived stem cells were used to attempt to differentiate into another form of cell type, the tissue had to be guided to attempt this differentiation. With human amniotic cells, the communication between host cells and the grafts are pivotal in creating the healing process for damaged tissues.

One future application is using amniotic stem cells to treat babies with congenital heart defects. Although this research is still in the very early phases, it has the potential to treat thousands of babies who are born each year suffering from congenital heart defects. By treating this type of defect, the child would avoid multiple heart operations and the strong possibility of a transplant before the age of one. Research teams are looking at replacing the damaged cells or generating new tissue by augmenting the damaged heart. Researchers understand that the baby’s heart cells are functioning but the heart muscle developed abnormally for reasons unknown.

Stem Cells Derived from Amniotic Fluid: New Potentials in Regenerative Medicine

Human amniotic cells have been used over the past 50 years as a diagnostic tool for prenatal diagnosis of genetic abnormalities in the fetus. Over the past 5 years, however, the potential for using stem cells derived from amniotic fluid has become a reality, especially for treating chronic diseases and conditions.

Stem Cells for Rotator Cuff Tears

Amniotic fluid derived stem cell therapy works well for rotator cuff tears

Amniotic derived stem cells can be harvested from the amniotic sac of a pregnant female. This occurs during child birth or during a procedure called amniocentesis. Since amniocentesis has slight risks, the most common scenario is that amniotic fluid  is obtained during a caesarean section from a consenting donor.

Otherwise it would be discarded, and thankfully amniotic fluid contains a very high concentration of stem cells.

These cells are prized for their ability to form a variety of differentiated cell lines such as blood, bone, muscle, liver, skin, and more. This is unlike the other types of stem cells (other than embryonic), which are only able to differentiate into certain types of tissues.

The Focus

The focus for using stem cells derived from amniotic fluid comes from the ethical battle fought over using embryonic stem cells. Many activists do not like the idea of using stem cells derived from fetuses. Instead, using stem cells derived from amniotic fluid solves this ethical issue. The mother can bank her amniotic fluid or the umbilical cord (which is also rich with stem cells) for later use.

The amniotic fluid found in the womb promotes the develop of the fetus. It is inhaled and exhaled by the fetus in the womb and directly responsible for the development of the lungs. The amniotic fluid promotes the development of the limbs, and passes through the body of the developing fetus re-entering the womb as urine.

How are Stem Cells Derived from Amniotic Fluid used in Research?

Amniotic Stem Cell TherapyThe amniotic cells used in research are primarily donated by mothers in their first trimester of pregnancy. Amniotic derived stem cells were found to have similar properties to embryonic stem cells after tests were performed.

Researchers found that the cells were grown and reprogrammed into a more primitive state when valproic acid was added to the culture medium. Tests run on these cells showed that amniotic derived stem cells have the capability to develop into any type of cell found in the body with a property called pluripotency.

The potential of using amniotic fluid to cure all kinds of diseases, disorders, and injuries is now a reality. Amniotic stem cells not only offer a rich cell line to assist in research but also seem to offer a customized cell supply for newborns and sometimes their siblings. These cells are the medium between embryonic stem cells and adult stem cell lines, such as bone marrow derived stem cells.

Research and the Future of Stem Cells

In the research arena, stem cells are grown in a culture, and there is potential for reengineering and regenerating cells and tissues. Some research has shown that amniotic derived stem cells differentiate using a scaffold or three-dimensional matrix for support.

These cells have been documented to have the ability to differentiate into all types of cells and tissues with a high renewal capacity and no loss of cellular integrity. Stem Cell therapy

The positives outweigh any thought of a negative aspect to using amniotic derived stem cells for treatment and therapy. It is believed that about 38 percent of the population could be treated as a match from stem cells harvested from about 150 donors. This is amazing statistics when you consider the closest approved therapy right now is bone marrow implantation, as well as the odds of finding a donor and the risk of rejection.

R3 Stem Cell offers amniotic stem cell therapy for numerous musculoskeletal conditions including plantar fasciitis, degenerative arthritis, rotator cuff and achilles tendonitis, ligament injury and more. Amniotic derived stem cell therapy offers nonoperative pain relief with the potential to regenerate damaged tissue!

Why is Amniotic Fluid so Great for Regenerative Medicine?

Amniotic fluid is the protective liquid that is contained within the amniotic sac of a Stem Cell Clinicpregnant mother. Amniotic fluid originates from the mother’s plasma and passes through the fetal membranes by way of osmotic and hydrostatic forces. It is important that the fetus inhales and exhales the amniotic fluid, so that the lungs develop normally.

The amniotic fluid also creates urine, and the fetus secretes and contributes to the formation of meconium. Additionally, amniotic fluid cushions the fetus from any jarring or blows to the mother’s abdomen and promotes the development of the fetus’ skeletal and muscular development.

Amniocentesis Procedure

When fluid is drawn out of the amniotic sac for evaluation, the doctor can determine the fetus’ genetic health. The amniotic fluid contains amniotic stem cells and fetal cells which can be examined for genetic abnormalities.

The procedure of removing amniotic fluid requires a thin needle to pass through the mother’s abdomen, the uterus, and into the amniotic sac where about 20 milliliters of fluid is withdrawn. The doctor uses imaging to determine the fetus’ position to minimize the danger to the fetus. There is less than a 1% risk of miscarriage with amniocentesis.

Amniotic Fluid and Stem Cells

Amniotic fluid contains a considerable amount of stem cells. These are distinguished as amniotic derived stem cells and are considered to be pluripotent, meaning that they can differentiate themselves into various tissues. These stem cells are non-embryonic and Stem Cells for plantar fasciitisare not derived from the embryo, so there is little resistance for using this type of stem cells in research.

Amniotic derived stem cells have shown in research the ability to differentiate into varying cell types, such as brain, bone, and liver tissues. Other types of stem cells do not have this functionality and are only able to differentiate into specified cell types. These types include bone marrow derived stem cells, which only differentiate into blood cells. The amniotic sac is not the only area that contains stem cells. The amnion, umbilical cord, and placenta have all been shown in studies to also contain amniotic derived stem cells, which can be isolated at birth.

Study Regarding Mesenchymal Cells

Amniotic fluid is considered to be so great because of the fairly plentiful source, easy retrieval, and safety associated with the procedure. In studies performed in-vivo, both pluripotent and multi-potent stem cells have been isolated from amniotic fluid. These cells were studied and proven to have the capability to differentiate into kidney and lung tissues, and this proves a potential promise to treat diseases which afflict these tissues.

There has been one case where amniotic derived stem cells have successfully been used for tissue reengineering. In the study, mesenchymal cells were isolated from the amniotic fluid and used to differentiate cartilage in-vivo while maintaining the scaffold for fifteen weeks separating.

Due to research and highly promising findings, amniotic stem banks have popped up around the world, with the main one in Massachusetts, United States. Other reasons amniotic derived stem cells are becoming so popular in research is storage at minimal cost, and over long periods of time with no adverse effects.  Amniotic stem cells are an excellent source of therapy for many genetic disorders which previously were untreatable.

In studies using animal models, these stem cells have shown promise in therapy, but this concept is still fairly new. More research is required to prove how effective amniotic stem cells could be in regenerative medicine. The possibilities are endless, and include therapy for the hematopoietic system, brain, bone, kidney, lung, heart, and other Stem Cell Treatmentimportant tissue types.

With amniotic stem cell treatments, the fluid actually comes after caesarean sections from women who donate it. Otherwise, the fluid would be discarded. Amniocentisis is not necessary for harvesting.

R3 offers amniotic stem cell therapy with stem cell doctors nationwide. Treatments are offered for numerous musculoskeletal conditions including rotator cuff tendonitis, knee arthritis, achilles tendonitis, plantar fasciitis, and more!

5 Things You Should Know About Amniotic-Derived Stem Cell Injections

In the past few years, we have experienced incredible advancement in the field of regenerative medicine, especially because the use of stem cells has been aggressively explored in order to offer solutions for managing pain and orthopedic conditions. Stem cell therapy has been rapidly embraced by the scientific community, both researchers and physicians, because of its amazing potential to heal damaged tissues, joints and other parts of the body. Stem Cell Clinics

One particular area of extensive exploration is the properties and role of amniotic membrane tissue in 21st century regenerative medicine. This increased interest is justified because there is an incredibly high amount of stem cells present in the amniotic tissues, much higher than the amount of stem cells found in adult bone marrow or adipose tissue (fat).

Ok, but what exactly is this amniotic tissue and what are amniotic stem cells?

The amniotic tissue is basically a membrane found in the center layer of the placenta, which is found in the amniotic cavity. This membrane has only one layer of tissue that contains a high number of specialized cells, who actually help the membrane to offer several functions aimed at healing.

During pregnancy, the fetus is surrounded by the amniotic fluid, which has a protective and a feeding role. Following a written consensus from donors, during a caesarean section, stem cells are collected from this amniotic fluid, processed and injected into patients who suffer from a variety of muscular conditions. These are not embryonic cells and there are no ethical concerns. In addition, this fluid is processed at an FDA regulated lab.

Lately, as technology progresses, a considerable amount of patients that have musculoskeletal problems are considering the use of amniotic derived stem cell injections in order to help their body naturally heal itself. And such a choice is justified when you consider the excellent properties of amniotic fluid: natural antiinflamatory response, pain relief, an abundance of growth factors that promote tissue growth, presence of hyaluronic acid that promotes the growth of new cartilages, and a massive concentration of stem cells which allow the body to accept and utilize the fluid without any immune reactions or rejection.

Bottom line is that amniotic derived stem cell injections have been used in the US for a few years now with very promising results, including physicians being successful in treating elbow tendon injuries such tennis elbow and golfer’s elbow, along with rotator cuff tendon injury, spine problems, joint arthritis, wound healing and even corneal injuries.

What’s the most important aspect to remember: amniotic derived stem cell injections help the body to replace damaged cells and also to create new cells, thus giving the body a chance to naturally heal itself. With the help of these injections you don’t just treat the pain itself, but you also treat the source of the pain.


  1. Amniotic stem cells have been found to have the potential to heal damaged tissues, joints and other parts of the body.
  2. More and more parents are allowing stem cells to be harvested from amniotic fluid for research and treatment of injuries and medical conditions.
  3. Amniotic-derived stem cells offer an incredible abundance of healing properties including: natural antiinflamatory response, pain relief, an abundance of growth factors that promote tissue growth, and presence of hyaluronic acid that promotes the growth of new cartilages.
  4. There is minimal chance of rejection or allergic reaction to treatment with amniotic-derived stem cells.
  5. This type of therapy has been successfully used to treat tendon injuries such tennis elbow and golfer’s elbow, rotator cuff tendon injury, spine problems, joint arthritis, and wound healing problems.

How does Amniotic Stem Cell Therapy Work for Rotator Cuff and Achilles Tendonitis?

Amniotic stem cell therapy is one of the most effective forms of treatment for many different conditions present within the tendons and joints. The amniotic tissue is contained within the uterus, and its main specialized duty if to offer regenerative healing properties to the fetus while in the mother’s womb.

There is a high amount of stem cells present in amniotic fluid, which makes it easy for the cells to be obtained and used for treatment. While the uses of amniotic stem cell therapy is still being researched, and additional treatment options are presenting themselves, this type of therapy is growing in popularity for conditions such as rotator cuff tendonitis, Achilles tendonitis, and other similar issues.

Amniotic Stem Cell Therapy

The rotator cuff is a structure within the body that works to support the shoulder, and offers significant stability. The cuff is made from a variety of tendons, which work together to create the support. When one of the tendons becomes damaged due to excessive use, trauma, or another issue with the area, the condition is known as tendonitis of the rotator cuff. Surgical procedures do not always help the condition, and could actually cause it to become worse in some cases.

When amniotic stem cell therapy is used for issues with the rotator cuff, there are a few different ways in which the therapy works. For one, when there is an issue present with the tendon, the area will become inflamed, which can lead to pain, swelling, and joint immobility, and even the possibility of more damage occurring. The stem cells derived from the amniotic tissue have shown to help the area repair by providing it with anti-inflammatory effects, growth factors and stem cells. This will decrease the amount of pain present and also take pressure off of the damaged tendon.

Other than taking away inflammation in the area, the amniotic stem cells work to help the tendon to regenerate. The tendon will experience healing in the form of thickening of the tissue within the tendon and regeneration of the structure where damage has occurred. The hyaluronic acid in the amniotic stem cell material also provide lubrication to the tendon, which will prevent further damage from occurring in the area while healing takes place.

The Achilles tendon is the largest tendon in the body, and it goes from the area of the heel, to the top of the calf. When stem cell therapy is used for this area, the healing action is done in the same manner as for the conditions with the tendon in the rotator cuff. While inflammation is sometimes seen with damage in the shoulder area, inflammation is the most common issue to occur when the Achilles tendon becomes damaged. The stem cells offer relief from inflammation, while also providing the area with the ability to repair itself.

How Amniotic Stem Cell Therapy is Provided

Amniotic stem cell therapy is done through the use of injections, which are made directly into the tendon, and they may also be made to the surrounding area. Once the injection is made, pain relief is often provided right away due to the anti-inflammatory properties, and healing will occur at a fast rate as well. However, the rate can differ between patients due to age, the amount of damage present, and the body’s response to the therapy.

R3 Stem Cell Clinics offer first rate, Board Certified doctors who are highly skilled in stem cell therapy. If you or a loved one is suffering from pain in the shoulder, heel, achilles and other areas, stem cell injections  with amniotic fluid derived treatment may help. Call an R3 stem cell clinic today!

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