Call US NOW (844) GET-STEM

Call US NOW (844) GET-STEM


Regenerative Medicine

Innovative Therapy for Pain on Inside of Elbow

Inflammation of the tendon (tendonitis) is the most common cause of golfers and tennis elbow (pain on inside of elbow and outside of the elbow, respectively). The reason why golfers and tennis elbow occur is due to repetitive movements where the tendons around the elbow persistently rub over the bony aspects of the joint. This occurs when performing activities such as swinging a golf club or tennis racquet, or when performing normal activities such as shaking hands, opening a door, or lifting up objects.

Pain on inside of elbow - Elbow TendonitisSigns and symptoms of elbow tendonitis    

Elbow tendonitis can be an extremely painful condition that can cause disability in patients to the point where they cannot perform their normal daily activities.

Affected individuals will complain of severe pain over the inside or outside aspects of the elbow, depending on which tendons are affected, and this can be associated with tenderness and swelling of the joint. There may also be limited mobility of the elbow with a decreased range of motion. Pain in the joint may also refer up and/or down the arm, with pain being experienced in the shoulder and/or wrist joints, respectively.

Management of elbow tendonitis

Elbow tendonitis can heal by itself with supportive measures such as resting the limb of the affected joint, applying cold compresses to the tender area, and by using an elbow support or strap. Resting the wrist joint is actually part of the protocol of golfer’s and tennis elbow treatments because when this joint is rested, the muscle and tendons in the forearm rest and can recover over a shorter period of time. Anti-inflammatory medications are used to help offer pain relief by reducing the inflammatory response in the tendons of the affected elbow.

If these conservative golfer and tennis elbow treatments are not effective, then physical therapy and even surgery may be indicated. Before surgery is warranted though, innovative therapies can be initiated.

Platelet-rich plasma and stem cell therapy

Platelet-rich plasma (PRP), derived from the patient’s own blood, is a safe and effective therapy in the treatment of elbow tendonitis. The PRP is administered to the patient via an injection and this promotes tissue repair in the damaged tendon. This process involves the platelet cells stimulating the release of growth factor and stem cells from the body which is essential for tissue repair and natural healing.

Stem cells derived from the bone marrow were used in a previous study that demonstrated the usefulness of surgery followed by stem cell administration for managing severe and persistent cases of tennis elbow. The outcomes of the patients who were administered stem cells were an early return to daily activities following surgery, and a reduction in complications on their follow-up visits. Tendon repair was evident when the tissue was observed through ultrasound techniques.

Stem cells have also been derived from adipose (fat) tissue. These cells take longer to be harvested from adipose tissue, but they can be stored and used at a later stage. The stem cells collected from fat are, like PRPs, derived from the patient and does not involve the harvesting cells from embryos.

Stem Cell Therapy for Wound Healing

Nonhealing wounds due to venous leg ulcers or diabetic neuropathy can lead to systemic infection or osteomyelitis, which can result in the need for amputation. Fortunately, treatment with amniotic membrane has been shown to work significantly better than traditional treatments. While the membrane itself has no stem cells in it, there are significant amounts of growth factors. A lot of wound physicians will inject amniotic fluid around the sides of the wound as well to assist with wound closure too!

 

FAQs on Stem Cell Procedures for Elbow Tendonitis

Stem cell procedures are an excellent method to treat elbow tendonitis thanks to the natural repair and regeneration. Be it tennis elbow or golfer’s elbow, tendonitis is traced to chronic inflammation of an elbow tendon. Stem cell therapy can relieve pain in the short term and restore the damaged tendon in the long term.

What are stem cells?

Stem cells differ from all other cells in our body due to their ability to become most other cells. These cells replicate into cells found in the part of the elbow painbody where these are injected.

What is the source of stem cells used to treat elbow tendonitis?

Stem cells are sourced from the bone marrow, fat cells, or from amniotic fluid.

Fat and bone marrow are harvested from the patient him or herself. Amniotic fluid is harvested from a consenting mother after a scheduled c-section.

How does stem cell therapy treat elbow tendonitis?

Elbow tendonitis encompasses two types of injuries – tennis elbow (lateral epicondylitis) and golfer’s elbow (medial epicondylitis) – both have their origin in tendinitis or degeneration of musculature leading to chronic inflammation of elbow tendons. Tennis elbow occurs in the outer tendons, while golfer’s elbow affects the inner tendons.

Stem cells injected into the area of the injured tendon help to repair and regenerate the damage by converting into tendon cells, while also promoting new blood vessel formation.

How successful is stem cell therapy to treat elbow tendonitis?

Stem cell procedures for elbow tendonitis are popular with both golfers and tennis players.

  • A study carried out by the Jefferson-based Rothman Institute showed 61% of those treated with stem cell therapy for tennis elbow had significant improvement in pain and tenderness compared to 50% in the non-stem cell group over a period of 24 weeks.
  • A study attributed to researchers from South Florida attests the fact that stem cell procedures for elbow tendonitis brings down pain considerably and improves disability.
  • A Stanford University study published in 2006 claims 93% improvement in chronic elbow tendonitis when stem cell procedures are used.
  • A 2012 study reported 66% percent more pain relief from stem cell therapy compared to corticosteroid injections.

What are the advantages of stem cell therapy for elbow tendonitis compared to other treatments?tennis elbow

  • Healing by the human body itself
  • Non-invasive and no need for surgery
  • Complete and fast recovery
  • Outpatient procedure
  • Nonsteroidal

How are stem cells to treat elbow tendonitis harvested?

Stem cells used to treat elbow tendonitis are harvested from the bone marrow or one’s fat (adipose). The procedure takes about half an hour.

Amniotic fluid is obtained from consenting  mothers after a scheduled c-section. The fluid is then processed at an FDA regulated lab and cryogenically frozen until it’s time for the procedure. There are no rejection issues as the fluid is immunologically privileged.

How is the stem cell therapy for elbow tendonitis performed?

The skin above the tendon causing pain is numbed and stem cells are injected into the area. Often times, the needle is also used to “poke holes” in the bone too so bleeding is stimulated for repair. These stem cells start to multiply themselves soon after being injected. These new cells replace the old and damaged cells and anchor the repair job. The process goes on for months.maxresdefault

What are post-procedure cautions to be followed?

You may have to use an elbow sling for a day. Activity should be limited for approximately 48 hours, then resumed as tolerated.

What are the side effects of stem cell procedures for elbow tendonitis?

Complications are unusual and may include infection, bleeding or soreness.

Do I need more than one stem cell procedures for elbow tendonitis?

Patients usually need one stem cell procedure to treat elbow tendonitis. However, at times a second procedure may be necessary for optimal relief.

 

References

Singh A, Gangwar DS, Singh S. Bone marrow injection: A novel treatment for tennis elbow. Journal of Natural Science, Biology, and Medicine. 2014;5(2):389-391.

Lui PPY. Stem cell technology for tendon regeneration: current status, challenges, and future research directions. Stem Cells and Cloning : Advances and Applications. 2015;8:163-174.

Carvalho A de M, Badial PR, Álvarez LEC, et al. Equine tendonitis therapy using mesenchymal stem cells and platelet concentrates: a randomized controlled trial. Stem Cell Research & Therapy. 2013;4(4):85.

Ho JO, Sawadkar P, Mudera V. A review on the use of cell therapy in the treatment of tendon disease and injuries. Journal of Tissue Engineering. 2014;5:2041731414549678.

Young M. Stem Cell Applications in Tendon Disorders: A Clinical Perspective. Stem Cells International. 2012;2012:637836.

Top 5 Definitions in Amniotic Stem Cell Treatments

Stem Cell Injections, Growth Factors, Cytokines, Hyaluronic Acid – WHAT ARE THESE?

When looking at receiving amniotic stem cell treatment to avoid surgery for arthritis, tendonitis, sports injuries, or for wound care or cosmetic purposes, it helps to know what these terms mean. You don’t need to be a PhD, but at least having a basic understanding of the components of the treatment being received can’t hurt! In this video, R3 Stem Cell CEO David Greene explains what they mean.

When you’re ready for treatment, call us at (844) GET-STEM!

 

Why Is There Great Interest in Stem Cells?

Stem cells, which may be thought of as the body’s natural repair kit, have created a lot of interest amongst medical researchers and doctors. In practical application and experimental trials, these cells have been found to have great power and potential in treating a long list of health care issues, including stem-cellsinjuries to the musculoskeletal system, wound healing, neurological disorders and injuries, heart problems, cancer, and much more.

Practitioners are currently using stem cells to treat various health concerns such as rheumatoid arthritis; ligament, tendon, and bone damage; and wounds. It’s expected that in a few years that list will expand greatly. Needless to say, there is great interest in these amazing powerful and versatile cells. What are the various benefits that can be associated with stem cells? They are numerous.

Greater Understanding of Disease

It’s hoped that researchers and doctors in the lab can learn more about diseases, including how and why they happen, by observing stem cells as they mature to become muscles, nerves, bones, and other tissues and organs. Because stem cells contain the basic components needed to repair the body in that they are the healthy cells that replace those that are damaged or diseased, there’s great hope that we can gain new and important insights into diseases and injuries that will lead to breakthroughs in medicine.

Development of More effective Treatments

In understanding more about disease and injuries and how these cells work in repairing the body, scientists see a future where a wide range of health issues can be addressed with the use of new stem cell therapies. Healthcare challenges that may benefit from this new knowledge and developing therapies include those related to spinal cord injuries, heart disease, stroke, burns, type 1 diabetes, Parkinson’s disease, Alzheimer’s disease, cancer, and osteoarthritis.

Revolution in Transplant and Regenerative Medicine

There’s great interest in stem cells due to the promise they hold for the development of transplant and regenerative medicine. Because of their vast potential to be grown and cultivated into new tissue, stem cells may have applications of which we are not even aware. The entire manner in which we treat very serious conditions and diseases may change drastically and success rates could rise dramatically as stem cell therapies are developed.

R3 Stem Cell is at the forefront of offering regenerative medicine for all types of musculoskeletal conditions. Call us today!

What Are the Latest Research Finding About Stem Cell Therapy Benefits For Knee Arthritis?

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Stem cell therapy has emerged as the most promising treatment to stop and reverse the effects of degenerative disorders, such as knee arthritis. Research publications worldwide attest its effectiveness in fast becoming a non-invasive substitute to surgical method and an alternative source of knee cartilage cell regeneration.

Scientific studies show that stem cell therapy has higher success rate in improving pain and disability associated with knee arthritis compared to any other treatment. The bio-restorative procedure with its unique natural healing ability also stimulates the regeneration of the damaged knee cartilage reversing the effects of arthritis.

How does stem cell therapy treat knee arthritis?

Knee arthritis causes permanent damage to the articular cartilage. As a result, bones in the knee joint rub with each other as we walk or bend the knee. This leads to pain and disability.

Stem cells have the unique ability to self-renew themselves and replicate other cells. When these cells are harvested and injected into the knee affected by arthritis, it triggers redevelopment of the damaged cartilage. Stem cells increase in numbers by self-renewing and differentiating themselves into cartilage cells. These new cells gradually replace the damaged and dead cells and heal the injury. This allows redevelopment of the cartilage and reversal of the damage caused by knee arthritis.

Is stem cell therapy for knee arthritis an alternative to surgery?

Stem cell therapy is fast emerging an alternative to surgical treatment of knee arthritis. Non-invasive, it assures better and permanent healing, pain management, greater freedom from disability, and faster recovery. The procedure completely reverses the damage to the cartilage by helping it to regenerate and thus heals the degeneration associated with knee arthritis.

As stem cells are harvested from the body of the patient, these do not pose any risk of rejection. Once the healing is complete, you regain knee strength equal to the pre-arthritis level and lead a pain-free life for a significantly longer period. The degree and duration of relief is far superior to the outcome of any other treatment or pain management method.

What Does The Latest Research Show?

The latest research on stem cell therapy highlights its wider application to treat and reverse the damage caused by degenerative disorders. According to research findings published in the Expert Opinion in Biological Therapies, stem cells are able to renew the damaged knee cartilage and undo the effects of arthritis. In a wider study reported in the Clinical Journal of Sports Medicine, researchers discovered that almost a third of patients studied had their cartilage degradation completely reversed within 12 months of having the procedure.

The results of a pilot study published in 2013 termed stem cell therapy a breakthrough treatment for patients suffering from knee arthritis. It provides significant improvement relieving pain and disability without any hospitalization or invasive surgery. The Stem Cells journal claims accelerated healing and recovery from knee arthritis is possible when a patient is treated with stem cell therapy.

The outcome of an 18-patient study published in the Stem Cells Translational Medicine journal that asserts that “a single injection of stem cells reduces pain and inflammation” and “improves mobility.” All were French and German patients aged 50 to 75 and had debilitating arthritis symptoms in their knees, such as severe inflammation, considerable pain, and crippling disability, for more than 12 months. Divided in to three groups – low-dose, medium-dose, and high-dose stem – each had a single injection of stem cells. A review after six months revealed that all patients had improvements as far as the severity of pain, functional disability, and mobility are concerned. Researchers observed “statistically significant” recovery even in the group with the lowest dose.

An analysis of current research on pharmacologic and regenerative therapies for osteoarthritis published in the Bone Research journal (Mar, 2016) acknowledges stem cell procedure as a “long-term solution to repair and regenerate cartilage, alleviate symptoms and finally delay progression of osteoarthritis.”

Meanwhile scientists at the Whitaker Biomedical Engineering Institute in Johns Hopkins have successfully generated precursor cartilage cells from stem cells. Sponsored by the Arthritis Foundation, the project showcases the promise of creating new bone or cartilage that could replace or repair the damage to the knee caused by osteoarthritis.

Encouraged by the “bio-restorative” qualities of stem cell therapy, the Rush University Medical Center ran the first ever nationwide clinical study of Cartistem – a first of its kind cartilage regeneration stem cell drug – between 2013 and 2015. Injected in to the knee area, it is touted to repair knee cartilage damaged by osteoarthritis. The trial that ended in May 2015 was promising and a detailed outcome report is expected next year.

Researchers at the St. Louis-based Washington University School of Medicine have also developed a new stem cell technique that can resurface an arthritic knee joint. As reported in the Proceedings of the National Academy of Sciences journal, stem cells are programmed to develop a new cartilage that has anti-inflammatory molecules, which prevents reoccurrence of arthritis.

Mesoblast, a leader in stem cell medicines, made a presentation at 2016 Amsterdam World Congress of the Osteoarthritis Research Society International about its MPC-75-IA drug made to turn around effects of knee arthritis. The manufacturer claimed that a single shot of its product, an intra-articular stem cell injection, was capable of significantly improving “pain, disability, cartilage thickness, and joint structure within 24 months.”

R3 Stem Cell offers stem cell therapy for knee arthritis at clinics nationwide. Treatment is offered with amniotic stem cell therapy for knees, bone marrow and adipose derived stem cells. Call (844) GET-STEM today!

References

Yves-Marie Persa, Lars Rackwitzc, Rosanna Ferreiraa, et al. Adipose Mesenchymal Stromal Cell-Based Therapy for Severe Osteoarthritis of the Knee: A Phase I Dose-Escalation Trial. STEM CELLS Translational Medicine; May 23, 2016, sctm.2015-0245

Wei Zhang, Hongwei Ouyang, Crispin R Dass. Current research on pharmacologic and regenerative therapies for osteoarthritis. Bone Research 4, Article number: 15040; 01 March 2016

Franklin Moutosa, Katherine Glass, Sarah Compton. Anatomically shaped tissue-engineered cartilage with tunable and inducible anticytokine delivery for biological joint resurfacing. Proceedings of the National Academy of Sciences; August 2, 2016; vol. 113 no. 31

PRP Therapy for Bones and Joints

prp

Platelet-rich therapy (PRP) is being used in surgeries to promote cell regeneration since 1987. The procedure involves taking the patient’s own blood, processing it in the laboratory to concentrate the platelets, and injecting the platelets into the body.

 

prp2

What are platelets?

 

 

Platelets are fragments of the megakaryocyte, which is a large cell in the bone marrow. Megakaryocytes differentiate and mature from stem cells, which retain the ability to renew themselves and turn into other specialized cells. In addition, platelets leave the bone marrow to circulate in the bloodstream. Platelets bring white blood cells to an injured area, facilitate blood clotting, release growth factors, and facilitate tissue regeneration.

 

Is PRP therapy proven to be effective?

 

There is much research to support that PRP therapy is effective for treating bone and joint conditions. Researchers studied 78 patients with knee osteoarthritis who received PRP injections. Compared to placebo saline injections, the study found that knees treated with PRP injections saw a reduction in stiffness and pain, and also, improved in function at the 3-month follow-up.

 

In a small study of patients with arthritic knees, MRI tests were used to evaluate joint damage following PRP injections. Patients receiving PRP injections had less pain after 12 months of therapy. In addition, MRIs showed that the degenerative process had not progressed in most patients who receive these treatments. The evidence also found that arthritis did not worsen, and patients had less pain than they did the previous year.

 

Am I a candidate for PRP therapy?

 

PRP does not help all patients with chronic pain, but it does work in certain situations. PRP appears to fail to treat symptoms in some people because of differences in PRP formulation and changes in certain variables, such as frequency of injections and the amount of PRP injected. PRP also does not appear to work for people with severe joint arthritis and degeneration.

 

How does PRP work?

 

When the concentrated platelet solution is injected into a damaged area, it stimulates the joint or bone causing mild PRP-2inflammation that triggers healing. As a result, new collagen forms, and as this collagen matures, it shrinks, tightens, and strengthens the body structures in the damaged area. The concentrated platelets also contain growth factors and bioactive proteins that initiate and accelerate tissue repair. These substances increase production of stem cells to stimulate connective tissue healing, bone repair and regeneration, and wound healing.

 

How does PRP compare to cortisone shots?

 

Cortisone shots offer only temporary pain relief by stopping inflammation. However, corticosteroids to not offer long-term healing like PRP. Studies show that PRP offers better tissue regeneration along with anti-inflammatory properties.

 

What body regions can be treated with platelet-rich platelet therapy?

 

PRP injections help regenerate many body areas, including the cervical (neck), thoracic (mid-back), and lumbar (low back) spine, elbows, shoulders, wrists, knees, hips, and ankles. Many orthopedic specialists use PRP therapy for sports injuries, degenerative joints, degenerative disc disease, and scoliosis.

 

How is platelet-rich plasma obtained?

 

Before a platelet-rich plasma procedure, the patient meets with the doctor for a consultation. After the decision to have PRP therapy is made, the blood is taken from the patient and placed in a special centrifuge. This device spins the blood to separate the platelets from the blood. After concentrating the platelets, the solution is injected into the damaged, injured, or degenerative body region.

Stem Cell Therapy is the Future of Orthopedic Medicine

R3-Stem-Cell_Banner_02

Regenerative therapies for the musculoskeletal system are the future of orthopedic medicine. Stem cell therapy is an innovative treatment that heals musculoskeletal problems without the need for surgery. In the United States alone, there are more than 500,000 spinal fusions and 400,000 lumbar discectomies performed each year. To avoid surgery, many people are choosing alternate forms of treatment.

 

What are stem cells?

 

Stem cells are undifferentiated cells in the body that can become many specialized types of cells. Adult stem cells are different from embryonic stem cells in that they are derived from adults, usually the patient’s own body. Stem cells used to treat musculoskeletal problems are called mesenchymal stem cells (MSCs), which turn into cartilage cells and bone cells.

 

How does stem cell therapy work?

 

The stem cells are obtained from the patient by aspirating tissue from fat (adipose) or taking bone marrow solution bone-marrow-aspiration2from the hip bone (iliac crest). The cells are spun in a centrifuge machine to identify and separate the stem cells that help heal tissues. Stem cells are injected into the damaged or injured body structure, such as a tendon, ligament, or spinal disc.

The additional method of obtaining stem cells includes amniotic fluid. This is obtained from consenting mothers of those scheduled for a c-section. The fluid is processed at an FDA regulated lab and prepared for use.

 

 

How are the stem cells obtained?

 

The human body has many stem cell storage sites. The easiest method for obtaining stem cells is to remove them from the hip bone (iliac crest). The procedure is done at the physician’s office, and it begins with the patient lying face down on the exam table. The skin over the bone is cleaned with an antiseptic, then numbed using a lidocaine solution. Under x-ray guidance, a procedure needle is inserted into the bone’s cortex. The liquid marrow is then withdrawn into a syringe. After the needle is removed, a bandage is applied. After the procedure, the stem cells are processed in the laboratory to concentrate them.

 

What conditions are treated with stem cell injections?

 

Stem cell injections are often used for the treatment of:

 

  • Muscular tears
  • Chronic partial rotator cuff tears
  • Osteoarthritis of the shoulder, hip, knee, and ankle joints
  • Discogenic back pain
  • Meniscal and cartilage tears in the knee
  • Spinal facet pain
  • Chronic radiculopathy
  • Sacroiliac joint pain

 

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What risks are associated with stem cell treatments?

 

The risks associated with stem cell injections include infection, nerve damage, and bleeding. However, these incidents rarely occur. There is no risk for allergic reaction since your own stem cells are used during the procedure. We recommend only effective, safe procedures for our patients.

 

When will I notice benefit from the injections?

 

The benefit occurs 2-3 months following the whole therapy protocol. For most patients, 3-4 injections are necessary, and we usually will only perform 3 injections within a 12-month time span.

 

Do stem cell injections work?

 

In a very recent study, researchers followed 18 patients who suffered from osteoarthritis of the knee, ankle, and/or hip. Each of these patients received one stem cell injection and were followed by laboratory and MRI tests for several months. All 18 patients showed therapeutic benefits, such as decreased pain, increased walking distance, and improved function scores. In addition, MRI results improved. In 2011, a study involving 339 patients with knee osteoarthritis found that 60% of patients had pain relief after the stem cell therapy. In addition, only 6% still required a total knee replacement.

 

Resources

Centeno C, Schultz J, Cheever M. Safety and complications reporting on the re-implantation of culture-expanded mesenchymal stem cells using autologous platelet lysate technique. Curr Stem Cell. 2011;5(1):81–93. doi: 10.2174/157488810790442796.

Emadedin M, Ghorbani-Liastani M, Fazeli R, et al. (2015). Long-Term Follow-up of Intra-articular Injection of Autologous Mesenchymal Stem Cells in Patients with Knee, Ankle, or Hip Osteoarthritis. Arch Iran Med, 18(6), 336-344.

Pak J. Regeneration of human bones in hip osteonecrosis and human cartilage in knee osteoarthritis with autologous adipose derived stem cells: a case series. J Med Case Rep. 2001;5:296. doi: 10.1186/1752-1947-5-296.

Amniotic Stem Cell Therapy for Diabetic and Peripheral Neuropathy

 
Amniotic Stem Cell Therapy for
Diabetic and Peripheral Neuropathy

By David Greene MD, MBA
Neuropathic Pain
Diabetic and Peripheral Neuropathy pain affect 6% of the population.
70% of diabetics suffer from neuropathy.
Pain is sharp, burning, lancinating, electric.
Not just pain, the decreased sensation affects walking ability.
Neuropathy Traditional 
Treatment Options
Opioids and NSAIDs
Oral and Topical
Questionable Benefit
Off label tricyclic antidepressants, anticonvulsants.
Neurontin, Lyrica
TENS unit
Only 30% achieve adequate relief with these methods.
Neuropathy Traditional 
Treatment Options
Spinal Cord Stimulator Implant
Revolutionary for relief and sensation return.
Over 80% pain relief.
85% improved sensation, 58% sensory deficits reversed completely.
Regenerative Medicine
The NEW paradigm, a nonoperative treatment that can actually repair damaged tissue. Provides pain relief and improved sensation.
Low risk, outpatient, effective – isn’t that what medicine has been looking for?
Consider this:
20 years ago plastic surgery was 90% operative. Now it’s 90% nonoperative!
Regenerative Options for
Diabetic and Peripheral Neuropathy
PRP Therapy
Blood draw, spun in centrifuge concentrates platelets/growth factors.
Bone Marrow
Adipose (fat)
The newest – Amniotic
Not really new
Used for decades
Amniotic Stem Cell Therapy
Remarkable addition to regenerative medicine.
Obtained from consenting donors after scheduled c-section.
FDA Regulated (CGTP)
AATB Certified
Cryogenically Frozen
No embryonic cells or fetal involvement
Amniotic Qualities
Immunologically Privileged
No Rejection Reaction
Growth Factors
Hyaluronic Acid
Stem Cells and Activators
Antimicrobial
NONsteroidal
Protocol
Amniotic stays on dry ice or in cryogenic freezer until ready to use.
Thaw for 10 minutes.
Usually 1-2 cc’s per limb, ok to dilute 3:1 with sterile water/saline/lidocaine.
Procedure takes less than a half hour.
Outcomes
We know that mesenchymal stem cells in animals significantly reduce neuropathic pain.
A preliminary report on stem cell therapy for neuropathic pain in humans – J Pain Res 2014
10 pts, In this preliminary proof-of-concept study, the administration of a mixed population of adipose-derived cells, including MSCs, was shown to be able to attenuate orofacial neuropathic pain symptoms in a diverse range of patients considering variables of age and the established duration of the pain state.

Outcomes
Anti-Inflammatory Mesenchymal Stem Cells (MSC2) Attenuate Symptoms of Painful Diabetic Peripheral Neuropathy 2012 Stem Cells Transl Med.
Over 40% inflammatory and pain reduction in mice.
Related to their capacity to not only control pain as a symptom, but to modulate the neuroimmune component which plays a relevant role in neuropathic pain.

Risks
Risks have been absolutely minimal.
Have not seen rejection
NO steroid.
It’s antimicrobial so risk of infection has been minimal.
Coverage
Currently amniotic stem cell therapy for neuropathy is an out of pocket expense.
Insurance will cover the visits, imaging, lab work but NOT the amniotic material.
New technology takes a while to capture reimbursement.
Bottom Line
Amniotic therapy works in preclinical studies and in early human pilot studies.
It is low risk, potential high benefit, and has live cells depending on processing.
No embryonic stem cells or fetal involvement!
Can help you and your loved ones avoid surgery and achieve relief and walk better.
R3 Stem Cell
R3 partners with top providers nationwide to offer regenerative treatments for all types of musculoskeletal conditions – knee, hip, shoulder, ankle, elbow, wrist, etc.
This includes back and neck conditions as well as neuropathy.
Visit us at R3StemCell.com and call us to find a treatment center at (844) GET-STEM.

What are the Benefits of Stem Cell Therapy?

A small number of stem cells taken from the body can grow in the laboratory setting to create millions of new stem cells. Known as regenerative medicine, stem cell-based therapies hold the promise of replacing and repairing damaged and disease body structures.

What ethical issues are associated with adult stem cell therapy?

Adult stem cells do not come from embryos. They cannot develop into a new human being. Rather, these cells reside in the fat and bone marrow in large quantities.stem-cells2

How do I know if stem cell therapy is right for me?

Consult with your orthopedic specialist if you suffer from a degenerative disease, have an acute injury, or have chronic joint pain. Stem cells come from the patient’s own body, and these cells help heal and repair damaged tissues.

What are the side effects of stem cell therapy?

Stem cell therapy is a safe procedure. After you undergo a medical evaluation, the specialist will determine if you are a candidate for this particular therapy. Some patients experience soreness and pain right after the procedure. However, because autologous (from the patient) fat and blood are used, there is no chance for allergic reaction.

What are the benefits of stem cell therapy?

Repair, healing, and regeneration of damaged or injured tissue are the main benefits of stem cell therapy. Stem cells can regenerate tissues that are injured, such as ligaments, menisci, and the rotator cuffs. In addition, tissues that are chronically damaged can be repaired from diseases such as osteoarthritis, tennis elbow, and bursitis. Stem cell therapy is a procedure offered in the office setting using local anesthesia, which eliminates the risks associated with general anesthesia.

How do stem cells from fat differ from those derived from bone marrow?

Adipose (fat) stem cells and stem cells from bone marrow both are adult mesenchymal stem cells. Adipose stem cells are collected bone marrow aspiration2form a mini-liposuction procedure, whereas bone marrow stem cells are aspirated from the hip bone. While adipose stem cells have regenerative properties to make blood vessels (essential for nutrient and oxygen delivery to tissues), bone marrow stem cells have superior ability to differentiate into cartilage, ligaments, and bone.

How do I prepare for the stem cell therapy procedure?

To prepare the body to better receive the stem cells, we encourage patients to undergo a simple detox before the treatment. This involves stopping smoking, avoiding alcohol, and taking vitamins, which cleanses the system from toxins.

How is the stem cell injection done?

To assure correct placement, stem cell injections are done using fluoroscopy (x-ray guidance), which allows the doctor to visualize the site of injury and offer effective, accurate treatment. After cleansing the skin with an antiseptic solution, the needle is guided into the treatment region, and the stem cells are injected.

How soon can I go back to usual activities after stem cell injection?home_service01

The procedure is done outpatient, so you are allowed to leave the medical facility that day. Patients are typically sore during the first couple of days following the injection, but they can return to work after 3-4 days. This depends, however, on the site of treatment and the type of physical activity required for the patient.

Are stem cell injections effective?

In recent research studies, intra-articular stem cell injections for arthritis have been investigated. Studies used both bone marrow-derived and adipose-derived stem cells. Researchers found that injection of stem cells allowed for improvement in pain scores, increased range of motion, and better outcome scores at 6-12 months post-procedure. In addition, researchers found that participants had increases in cartilage growth and thickness, which were evident on MRI.

Resources

Centeno CJ, Busse D, Kisiday J, Keohan C, Freeman M, Karli D. Increased knee cartilage volume in degenerative joint disease using percutaneously implanted, autologous mesenchymal stem cells. Pain Physician. 2008;11(3):343–353.

Davatchi F, Abdollahi BS, Mohyeddin M, Shahram F, Nikbin B. Mesenchymal stem cell therapy for knee osteoarthritis. Preliminary report of four patients. Int J Rheum Dis. 2011;14(2):211–215.

Emadedin M, Aghdami N, Taghiyar L, et al. Intra-articular injection of autologous mesenchymal stem cells in six patients with knee osteoarthritis. Arch Iran Med. 2012;15(7):422–428.

Orozco L, Munar A, Soler R, et al. Treatment of knee osteoarthritis with autologous mesenchymal stem cells: a pilot study. Transplantation. 2013;95(12):1535–1541.

Varma HS, Dadarya B, Vidyarthi A. The new avenues in the management of osteo-arthritis of knee – stem cells. J Indian Med Assoc. 2010;108(9):583–585.

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